Literature summary for 3.5.4.37 extracted from

Zhou, S.; Yang, C.; Zhao, F.; Huang, Y.; Lin, Y.; Huang, C.; Ma, X.; Du, J.; Wang, Y.; Long, G.; He, J.; Liu, C.; Zhang, P.
Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR (2019), J. Biol. Chem., 294, 18168-18180 .

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Application

Application	Comment	Organism
drug development	the enzyme (ADAR1) promotes the Zika virus replication by inhibiting the activation of protein kinase PKR. The enzyme can be a potential target of antiviral drugs	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P55265	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioblastoma cell	-	Homo sapiens	-
HEK-293 cell	-	Homo sapiens	-
lung cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ADAR1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme (ADAR1) regulates the phosphorylation of activation of protein kinase (PKR) and eukaryotic translation initiation factor 2 alpha (eIF2) in both an IFN-dependent and IFN-independent manner, and its inhibitory effect on the IFN production partially contributes to its proviral effect. The enzyme promotes the Zika virus replication by inhibiting the activation of protein kinase PKR	Homo sapiens

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Release 2023.1 (January 2023)