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Literature summary for 3.4.24.B11 extracted from
- Purification of an insect derived recombinant human ADAMTS-1 reveals novel gelatin (type I collagen) degrading activities (2006), Mol. Cell. Biochem., 281, 95-102.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | tumor growth inhibitor | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in High-FiveTM insect cells with pIB/V5-His insect cell expression vector | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
pro-domain off form of ADAMTS-1 | Homo sapiens |
| 115000 | - |
pro-domain on form of ADAMTS-1 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UHI8 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Hi-trap heparin-sepharose column chromatography and Nickel-chelating chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | in 50 mM Tris-HCl, pH 7.6, 150 mM NaCl and 5mM CaCl2 solution with 100 ng recombinant ADAMTS-1 at 37°C | Homo sapiens | ? | - |
? |  |
| Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| versican + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS-1 | a disintegrin and metalloprotease with thrombospondin repeats | Homo sapiens |
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