Cloned (Comment) | Organism |
---|---|
the gene encoding IDE is located on chromosome 10q23-q25, a gene locus linked to schizophrenia | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | metallopeptidase | Homo sapiens | |
Zn2+ | metallopeptidase | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-endorphin + H2O | Homo sapiens | - |
gamma-endorphin + ? | - |
? | |
beta-endorphin + H2O | Rattus norvegicus | - |
gamma-endorphin + ? | - |
? | |
Glucagon + H2O | Homo sapiens | - |
? | - |
? | |
Glucagon + H2O | Rattus norvegicus | - |
? | - |
? | |
insulin + H2O | Homo sapiens | high specificity | insulin peptide fragments | - |
? | |
insulin + H2O | Rattus norvegicus | high specificity | insulin peptide fragments | - |
? | |
insulin-like growth factor I + H2O | Homo sapiens | - |
insulin-like growth factor I peptide fragments | - |
? | |
insulin-like growth factor I + H2O | Rattus norvegicus | - |
insulin-like growth factor I peptide fragments | - |
? | |
insulin-like growth factor II + H2O | Homo sapiens | - |
insulin-like growth factor II peptide fragments | - |
? | |
insulin-like growth factor II + H2O | Rattus norvegicus | - |
insulin-like growth factor II peptide fragments | - |
? | |
additional information | Homo sapiens | IDE is a neutral thiol metalloprotease | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | left and right dorsolateral prefrontal cortex, expression of IDE protein in postmortem brains of healthy subjects and patients with schizophrenia, immunohistochemic analysis, overview | Homo sapiens | - |
brain | left and right dorsolateral prefrontal cortex, immunohistochemic IDE expression analysis, overview | Rattus norvegicus | - |
hypothalamus | - |
Rattus norvegicus | - |
hypothalamus | high IDE content | Homo sapiens | - |
neuron | - |
Homo sapiens | - |
neuron | - |
Rattus norvegicus | - |
SH-SY5Y cell | a neuroblastoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-endorphin + H2O | - |
Homo sapiens | gamma-endorphin + ? | - |
? | |
beta-endorphin + H2O | - |
Rattus norvegicus | gamma-endorphin + ? | - |
? | |
Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
Glucagon + H2O | - |
Rattus norvegicus | ? | - |
? | |
insulin + H2O | high specificity | Homo sapiens | insulin peptide fragments | - |
? | |
insulin + H2O | high specificity | Rattus norvegicus | insulin peptide fragments | - |
? | |
insulin-like growth factor I + H2O | - |
Homo sapiens | insulin-like growth factor I peptide fragments | - |
? | |
insulin-like growth factor I + H2O | - |
Rattus norvegicus | insulin-like growth factor I peptide fragments | - |
? | |
insulin-like growth factor II + H2O | - |
Homo sapiens | insulin-like growth factor II peptide fragments | - |
? | |
insulin-like growth factor II + H2O | - |
Rattus norvegicus | insulin-like growth factor II peptide fragments | - |
? | |
additional information | IDE is a neutral thiol metalloprotease | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Homo sapiens |
IDE | - |
Rattus norvegicus |
Insulin-degrading enzyme | - |
Homo sapiens |
Insulin-degrading enzyme | - |
Rattus norvegicus |
Insulinase | - |
Homo sapiens |
Insulinase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia | down |
Rattus norvegicus | reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated rats | down |
General Information | Comment | Organism |
---|---|---|
malfunction | reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated patients or patients with chronic schizophrenia. Reduced cortical IDE expression might be part of the disturbed insulin signaling cascades found in schizophrenia. Furthermore, it might contribute to the altered metabolism of certain neuropeptides, IGF-I and IGF-II, betab-endorphin, in schizophrenia | Homo sapiens |
malfunction | reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated rats | Rattus norvegicus |