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Literature summary for 3.4.23.46 extracted from
- Increased BACE1 activity inhibits peripheral nerve regeneration after injury (2017), Neurobiol. Dis., 106, 147-157 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta precursor protein + H2O | Mus musculus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P56818 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuron | - |
Mus musculus | - |
| sciatic nerve | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta precursor protein + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Mus musculus |
| beta-site APP-cleaving enzyme 1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enzyme activity levels have an inverse effect on peripheral nerve repair after injury. Neuronal enzyme activity levels impact peripheral nerve regeneration. Enzyme overexpression impairs axonal regeneration as early as 3 days after injury and leads to impaired axonal regeneration 10 days after injury | Mus musculus |
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Release 2023.1 (January 2023)
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