Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6R)-2,6-anhydro-5-O-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-[2-[(2R)-2-hydroxypropyl]-7-methoxy-5-methyl-4-oxo-4H-chromen-8-yl]-L-glucitol | inhibitor isolated from Aloe vera and Aloe nobilis. Inhibition of amyloid beta1-42 production by 7.4% in B103 neuroblastoma cells at 30 ppm | Homo sapiens | |
(6R)-2,6-anhydro-6-[7-methoxy-5-methyl-4-oxo-2-[(1E)-prop-1-en-1-yl]-4H-chromen-8-yl]-L-glucitol | inhibitor isolated from Aloe vera and Aloe nobilis. Inhibition of amyloid beta1-42 production by 12.3% in B103 neuroblastoma cells at 30 ppm | Homo sapiens | |
1,5-anhydro-1-[7-hydroxy-2-[(2S)-2-hydroxypropyl]-5-methyl-4-oxo-4H-chromen-8-yl]hexitol | 37.2% inhibition at 0.1 mM | Rattus norvegicus | |
1,5-anhydro-1-[7-hydroxy-5-methyl-4-oxo-2-(2-oxopropyl)-4H-chromen-8-yl]-2-O-[(E)-2-(4-hydroxyphenyl)ethenyl]hexitol | 39.5% inhibition at 0.1 mM | Rattus norvegicus | |
1,5-anhydro-1-[7-methoxy-5-methyl-4-oxo-2-(2-oxopropyl)-4H-chromen-8-yl]hexitol | 41.0% inhibition at 0.1 mM | Rattus norvegicus | |
1,5-anhydro-2-O-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-1-[7-hydroxy-5-methyl-4-oxo-2-(2-oxopropyl)-4H-chromen-8-yl]hexitol | 36.4% inhibition at 0.1 mM | Rattus norvegicus | |
1,5-anhydro-2-O-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-1-[7-methoxy-5-methyl-4-oxo-2-(2-oxopropyl)-4H-chromen-8-yl]hexitol | 48.7% inhibition at 0.1 mM | Rattus norvegicus | |
2'-O-coumaroyl-(S)-aloesinol | 51.9% inhibition at 0.1 mM | Rattus norvegicus | |
2'-O-[p-methoxy-(E)-cinnamoyl]-(S)-aloesinol | 34.1% inhibition at 0.1 mM | Rattus norvegicus | |
8-C-glucosyl-(R)-aloesol | 39.2% inhibition at 0.1 mM | Rattus norvegicus | |
8-C-glucosyl-7-methoxy-(R)-aloesol | 26.8% inhibition at 0.1 mM | Rattus norvegicus | |
8-C-glucosyl-7-O-methylaloediol | - |
Rattus norvegicus | |
allo-aloeresin D | - |
Rattus norvegicus | |
aloeresin D | 71.5% inhibition at 0.1 mM | Rattus norvegicus | |
aloesin | 37.5% inhibition at 0.1 mM | Rattus norvegicus | |
C-2'-decoumaroyl-aloeresin G | 72.0% inhibition at 0.1 mM | Rattus norvegicus | |
N-benzyloxycarbonyl-Val-Leu-leucinal | - |
Rattus norvegicus | |
rebaichromone | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-103 cell | - |
Rattus norvegicus | - |
commercial preparation | recombinant enzyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)-acetyl-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys-(2,4-dinitrophenyl)-Arg-Arg-NH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
7-methoxycoumarin-4-yl-acetyl-SEVNLDAEFR-(2,4-dinitrophenyl)K-RR + H2O | - |
Homo sapiens | ? | - |
? | |
amyloid precursor protein + H2O | - |
Rattus norvegicus | amyloid protein 1-42 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Rattus norvegicus |
beta-secretase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0116 | - |
- |
Rattus norvegicus | N-benzyloxycarbonyl-Val-Leu-leucinal | |
0.0205 | - |
- |
Rattus norvegicus | C-2'-decoumaroyl-aloeresin G | |
0.0205 | - |
pH 4.0, 25°C | Homo sapiens | (6R)-2,6-anhydro-6-[7-methoxy-5-methyl-4-oxo-2-[(1E)-prop-1-en-1-yl]-4H-chromen-8-yl]-L-glucitol | |
0.039 | - |
- |
Rattus norvegicus | aloeresin D | |
0.039 | - |
pH 4.0, 25°C | Homo sapiens | (6R)-2,6-anhydro-5-O-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-[2-[(2R)-2-hydroxypropyl]-7-methoxy-5-methyl-4-oxo-4H-chromen-8-yl]-L-glucitol |