Literature summary for 3.4.23.46 extracted from

Choi, S.H.; Hur, J.M.; Yang, E.J.; Jun, M.; Park, H.J.; Lee, K.B.; Moon, E.; Song, K.S.
Beta-secretase (BACE1) inhibitors from Perilla frutescens var. acuta (2008), Arch. Pharm. Res., 31, 183-187.

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Application

Application	Comment	Organism
medicine	screening of natural products for anti-dementia agents	Perilla frutescens

Inhibitors

Inhibitors	Comment	Organism	Structure
luteolin	isolated from methanolic extracts of Perilla frutescens	Perilla frutescens
rosmarinic acid	isolated from methanolic extracts of Perilla frutescens	Perilla frutescens

Organism

Organism	UniProt	Comment	Textmining
Perilla frutescens	-	var. acuta	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	methanolic extracts of Perilla frutescens	Perilla frutescens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	beta-secretase (BACE1) inhibitors isolated from the methanolic extract of Perilla frutescens characterized, specificity against beta-secretase BACE1 higher than for other enzymes such as alpha-secretase (TACE), acetylcholine esterase (AchE), chymotrypsin, and elastase	Perilla frutescens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	inhibitors of beta-secretase BACE1 identified and tested	Perilla frutescens	?	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Perilla frutescens
beta-secretase	-	Perilla frutescens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.039	-	rosmarinic acid	-	Perilla frutescens
0.062	-	luteolin	-	Perilla frutescens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0005	-	non-competitive inhibition	Perilla frutescens	luteolin
0.0021	-	non-competitive inhibition	Perilla frutescens	rosmarinic acid

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Release 2023.1 (January 2023)