Cloned (Comment) | Organism |
---|---|
expression analysis of caspase-8 in absence and presence of poly(ADP-ribose) polymerase 1, PARP-1, expression, the caspase-8 expression is not influenced | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | poly(ADP-ribose) polymerase 1, PARP-1, suppression does not affect procaspase-8 expression, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bid protein + H2O | Homo sapiens | i.e. BH3 interacting domain death agonist protein | cleaved Bid protein | - |
? | |
additional information | Homo sapiens | Fas-associated death domain-like IL-1beta-converting enzyme inhibitory protein, c-FLIP, can suppress Fas-mediated apoptosis by inhibition of caspase-8 activation. Caspase-8 is active via the death receptor-dependent pathway, or extrinsic pathway, complex formation and mechanism, overview | ? | - |
? | |
procaspase-3 + H2O | Homo sapiens | caspase-8 induces apoptosis by directly activating caspase-3, which in turn causes the characteristic features of apoptosis, including DNA fragmentation and cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | rheumatoid synovial | Homo sapiens | - |
additional information | constitutive pro-caspase-8 protein expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bid protein + H2O | i.e. BH3 interacting domain death agonist protein | Homo sapiens | cleaved Bid protein | - |
? | |
additional information | Fas-associated death domain-like IL-1beta-converting enzyme inhibitory protein, c-FLIP, can suppress Fas-mediated apoptosis by inhibition of caspase-8 activation. Caspase-8 is active via the death receptor-dependent pathway, or extrinsic pathway, complex formation and mechanism, overview | Homo sapiens | ? | - |
? | |
procaspase-3 + H2O | - |
Homo sapiens | ? | - |
? | |
procaspase-3 + H2O | caspase-8 induces apoptosis by directly activating caspase-3, which in turn causes the characteristic features of apoptosis, including DNA fragmentation and cell death | Homo sapiens | ? | - |
? |