Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the interferon regulatory factor 5, IRF-5, induces caspase-8 activation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | silencing of endogenous interferon regulatory factor 5, IRF-5, gives about 70% decrease in TRAIL-induced caspase-8 activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | nuclear colocalization of caspase-8 and Fas-associated death domain, FADD | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | interferon regulatory factor 5, IRF-5, promotes apoptosis upon signaling through tumor necrosis factor-related apoptosis-inducing ligand, TRAIL, death receptors, DR. IRF-5 is involved in DR signaling upstream of caspase-8 and induces caspase-8 activation, mechanisms, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-8 is activated by cleavage to caspase-8, induced by TRAIL, inhibited by IRF-5 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | interferon regulatory factor 5, IRF-5, promotes apoptosis upon signaling through tumor necrosis factor-related apoptosis-inducing ligand, TRAIL, death receptors, DR. IRF-5 is involved in DR signaling upstream of caspase-8 and induces caspase-8 activation, mechanisms, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase 8 | - |
Homo sapiens |