Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme acts as apoptosis initiator. Animals deficient in caspase-8 are embryonically lethal at approximately E12.5. Abnormal heart development and vascular hyperemia, EF resistant to Fas, TNF-alpha, and DR3 but exhibit normal sensitivity to UV, etoposide, low serum and staurosporine, death receptor signaling to JNK and NF-kappaB intact | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-8 possesses weak protease activity which may allow it to cleave other procaspase-8 molecules when in close proximity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the preferred cleavage sequence is LETD-/- | Homo sapiens | ? | - |
? | |
additional information | the enzyme acts as apoptosis initiator. Animals deficient in caspase-8 are embryonically lethal at approximately E12.5. Abnormal heart development and vascular hyperemia, EF resistant to Fas, TNF-alpha, and DR3 but exhibit normal sensitivity to UV, etoposide, low serum and staurosporine, death receptor signaling to JNK and NF-kappaB intact | Homo sapiens | ? | - |
? |