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Literature summary for 3.4.22.49 extracted from

  • Lin, Z.; Luo, X.; Yu, H.
    Structural basis of cohesin cleavage by separase (2016), Nature, 532, 131-134 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.49

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli strain BL21(DE3) Thermochaetoides thermophila

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of the separase protease domain from the thermophilic fungus Chaetomium thermophilum, alone or covalently bound to unphosphorylated and phosphorylated inhibitory peptides derived from a cohesin cleavage site Thermochaetoides thermophila

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Thermochaetoides thermophila the enzyme cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow chromosome segregation ?
-
 ?
cohesin + H2O Thermochaetoides thermophila DSM 1495 the enzyme cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow chromosome segregation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Thermochaetoides thermophila G0SHM3
-
-
Thermochaetoides thermophila DSM 1495 G0SHM3
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Thermochaetoides thermophila

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O
-
 Thermochaetoides thermophila ?
-
 ?
cohesin + H2O the enzyme cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow chromosome segregation Thermochaetoides thermophila ?
-
 ?
cohesin + H2O
-
 Thermochaetoides thermophila DSM 1495 ?
-
 ?
cohesin + H2O the enzyme cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow chromosome segregation Thermochaetoides thermophila DSM 1495 ?
-
 ?