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Information on EC 3.4.22.49 - separase

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.49 separase
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Word Map
  • 3.4.22.49
  • chromatid
  • anaphase
  • cohesin
  • mitosis
  • securin
  • spindle
  • metaphase
  • centromeres
  • meiotic
  • kinetochore
  • anaphase-promoting
  • checkpoint
  • prophase
  • aneuploidy
  • shugoshins
  • rad21
  • centriole
  • disjunction
  • centrosome
  • disengagement
  • sister-chromatid
  • metaphase-to-anaphase
  • biorientation
  • polo-like
  • medicaid
  • chiasmata
  • kleisin
  • missegregation
  • metaphase-anaphase
  • condensins
  • cyclosome
  • prometaphase
  • meiosis-specific
  • pp2acdc55
  • medicine
  • molecular biology
  • nondisjunction
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage
Synonyms
sep-1, separin, cut1/separase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage
show the reaction diagram
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