Literature summary for 3.4.22.49 extracted from

Luo, S.; Tong, L.
Structural biology of the separase-securin complex with crucial roles in chromosome segregation (2018), Curr. Opin. Struct. Biol., 49, 114-122 .

Search for more literature for 3.4.22.49

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of full-length separase in complex with securin	Saccharomyces cerevisiae
crystal structure of full-length separase in complex with securin	Caenorhabditis elegans
crystal structures of the active protease segment of Chaetomium thermophilum separase in complex with a substrate-mimic inhibitor at up to 1.85 A resolution	Thermochaetoides thermophila

Inhibitors

Inhibitors	Comment	Organism	Structure
securin	inhibits separase by binding as a pseudo substrate	Caenorhabditis elegans
securin	inhibits separase by binding as a pseudo substrate	Saccharomyces cerevisiae
securin	inhibits separase by binding as a pseudo substrate	Thermochaetoides thermophila

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	G5ED39	-	-
Saccharomyces cerevisiae	-	-	-
Thermochaetoides thermophila	G0SHM3	-	-
Thermochaetoides thermophila DSM 1495	G0SHM3	-	-

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Release 2023.1 (January 2023)