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Literature summary for 3.4.22.49 extracted from
- Biology and insights into the role of cohesin protease separase in human malignancies (2017), Biol. Rev. Camb. Philos. Soc., 92, 2070-2083 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chromosome | the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes | Homo sapiens | 5694 | - |
| cytoplasm | the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes | Homo sapiens | 5737 | - |
| nucleus | the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes | Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q14674 | - |
- |
| Mus musculus | P60330 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone cancer cell | overexpressed in numerous human cancers including breast, bone, brain, and prostate | Homo sapiens | - |
| brain cancer cell | overexpressed in numerous human cancers including breast, bone, brain, and prostate | Homo sapiens | - |
| breast cancer cell | overexpressed in numerous human cancers including breast, bone, brain, and prostate | Homo sapiens | - |
| prostate gland cancer cell | overexpressed in numerous human cancers including breast, bone, brain, and prostate | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ESPL1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme resolves sister chromatid cohesion during the metaphase-to-anaphase transition and plays a pivotal role in chromosomal segregation and cell division. In addition to its canonical role in the dissolution of chromosomal cohesin during metaphase to anaphase transition, separase is also implicated in centrosome cycle, membrane trafficking and DNA-damage repair | Homo sapiens |
| physiological function | the enzyme resolves sister chromatid cohesion during the metaphase-to-anaphase transition and plays a pivotal role in chromosomal segregation and cell division. Separase is oncogenic, and its overexpression is sufficient to induce mammary tumours in mice. Either acute or chronic overexpression of separase in mouse mammary glands leads to aneuploidy and tumorigenesis, and inhibition of separase enzymatic activity decreases the growth of human breast tumour xenografts in mice | Mus musculus |
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