Cloned (Comment) | Organism |
---|---|
expressed in Pichia pastoris | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(13alpha,17alpha,20S,24Z)-3-hydroxylanosta-7,24-dien-26-oic acid | competitive inhibition | Homo sapiens | |
(13alpha,17alpha,20S,24Z)-3-oxolanosta-7,24-dien-26-oic acid | competitive inhibition | Homo sapiens | |
(2E)-[(3E)-28-methoxy-28-oxours-12-en-3-ylidene]acetic acid | competitive inhibition | Homo sapiens | |
(3E)-3-(carboxymethylidene)olean-12-en-28-oic acid | competitive inhibition | Homo sapiens | |
(3E)-3-(carboxymethylidene)urs-12-en-28-oic acid | competitive inhibition | Homo sapiens | |
3-(hydroxyimino)masticadienoic acid | competitive inhibition | Homo sapiens | |
3-(hydroxyimino)oleanolic acid | competitive inhibition | Homo sapiens | |
3-epiursolic acid | competitive inhibition | Homo sapiens | |
3-hydroxyolean-12-en-28-oic acid | competitive inhibition | Homo sapiens | |
3-hydroxyurs-12-en-28-oic acid | competitive inhibition | Homo sapiens | |
3-oxoolean-12-en-28-oic acid | competitive inhibition | Homo sapiens | |
3-oxours-12-en-28-oic acid | competitive inhibition | Homo sapiens | |
E-64 | i.e. 1-[N-[(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl]amino]-4-guanidinobutane | Homo sapiens | |
methyl (13alpha,17alpha,20S,24Z)-3-hydroxylanosta-7,24-dien-26-oate | competitive inhibition | Homo sapiens | |
methyl (3Z,13alpha,17alpha,20S,24Z)-3-(hydroxyimino)lanosta-7,24-dien-26-oate | competitive inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatL | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
3-(hydroxyimino)oleanolic acid | at pH 5.5 and 37°C | Homo sapiens | |
0.00923 | - |
3-(hydroxyimino)masticadienoic acid | at pH 5.5 and 37°C | Homo sapiens | |
0.0195 | - |
3-epiursolic acid | at pH 5.5 and 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00003 | - |
at pH 5.5 and 37°C | Homo sapiens | E-64 | |
0.0024 | - |
at pH 5.5 and 37°C | Homo sapiens | 3-(hydroxyimino)oleanolic acid | |
0.0026 | - |
at pH 5.5 and 37°C | Homo sapiens | 3-(hydroxyimino)masticadienoic acid | |
0.0065 | - |
at pH 5.5 and 37°C | Homo sapiens | 3-epiursolic acid | |
0.0072 | - |
at pH 5.5 and 37°C | Homo sapiens | 3-hydroxyolean-12-en-28-oic acid | |
0.0082 | - |
at pH 5.5 and 37°C | Homo sapiens | (13alpha,17alpha,20S,24Z)-3-hydroxylanosta-7,24-dien-26-oic acid | |
0.0083 | - |
at pH 5.5 and 37°C | Homo sapiens | 3-oxours-12-en-28-oic acid | |
0.0091 | - |
at pH 5.5 and 37°C | Homo sapiens | (13alpha,17alpha,20S,24Z)-3-oxolanosta-7,24-dien-26-oic acid | |
0.0097 | - |
at pH 5.5 and 37°C | Homo sapiens | (3E)-3-(carboxymethylidene)olean-12-en-28-oic acid | |
0.0123 | - |
at pH 5.5 and 37°C | Homo sapiens | (3E)-3-(carboxymethylidene)urs-12-en-28-oic acid | |
0.0147 | - |
at pH 5.5 and 37°C | Homo sapiens | 3-oxoolean-12-en-28-oic acid | |
0.0395 | - |
at pH 5.5 and 37°C | Homo sapiens | 3-hydroxyurs-12-en-28-oic acid | |
0.25 | - |
IC50 above 0.25 mM, at pH 5.5 and 37°C | Homo sapiens | methyl (13alpha,17alpha,20S,24Z)-3-hydroxylanosta-7,24-dien-26-oate | |
0.5 | - |
IC50 above 0.5 mM, at pH 5.5 and 37°C | Homo sapiens | (2E)-[(3E)-28-methoxy-28-oxours-12-en-3-ylidene]acetic acid | |
0.5 | - |
IC50 above 0.5 mM, at pH 5.5 and 37°C | Homo sapiens | methyl (3Z,13alpha,17alpha,20S,24Z)-3-(hydroxyimino)lanosta-7,24-dien-26-oate |