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Literature summary for 3.4.21.83 extracted from
- Trypanosoma brucei brucei oligopeptidase B null mutants display increased prolyl oligopeptidase-like activity (2011), Mol. Biochem. Parasitol., 182, 7-16.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei brucei | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OPB | - |
Trypanosoma brucei brucei |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | oligopeptidase B null mutant parasites grow at a significantly faster rate in vitro, and are as virulent as wild type strains during infection in mice. Parasites are revealed in extra vascular regions showing that OPB is not involved in assisting Trypanosoma brucei parasites to cross microvascular endothelial cells. Null mutants show an increase in discrete cysteine peptidase activities when compared to wild type strains. A significant increase of prolyl oligopeptidase activity is observed in mutant, but no concomitant increase in prolyl oligopeptidase protein levels | Trypanosoma brucei brucei |
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Release 2023.1 (January 2023)
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