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Information on EC 3.4.21.83 - Oligopeptidase B
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3.4.21.83 Oligopeptidase BSpecify your search results
Word Map
- 3.4.21.83
- gingivalis
- leupeptin
-
prolyl
-
chymotrypsin-like
- antipain
- porphyromonas
- aprotinin
-
chloromethyl
- chymostatin
- tryptase
- tlck
-
2-macroglobulin
- benzamidine
-
phenylmethanesulfonyl
- acrosin
- proteamaculans
-
bapna
- medicine
- drug development
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
La_OpB, oligopeptidase B, oligopeptidase B-like, oligopeptidase B2, OP-Tb, OPB, OPB2, OPBTc, Opd B, OpdB, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
oligopeptidase B
OPB
OPBTc
Opd B
OpdB
Protease II
Proteinase, Escherichia coli alkaline, II
-
-
-
-
PSP
Spro_3467
trypsin-like protease
Protease II
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of -Arg-/-, -Lys-/- bonds in oligopeptides, even when P1' residue is proline
hydrolysis of Arg-+-, Lys-+- bonds in oligopeptides, even when P1' residue is proline, the term-+- depicts the point of cleavage
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
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CAS REGISTRY NUMBER
COMMENTARY
57657-67-7
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-ADGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ADGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AEGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AEGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AFGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AFGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGDRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGDR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGERGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGER + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGFRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGFR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGR + GAPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRDAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + DAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGREAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + EAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRFAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + FAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGADQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GADQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAEQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAEQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAFQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAFQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAHQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAHQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAIQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAIQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGALQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GALQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAMQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAMQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGANQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GANQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAPQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAQQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAQQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGASQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GASQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGATQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GATQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAVQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAVQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGAYQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAYQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGDGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GDGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGEGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GEGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGFGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GFGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGGGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GGGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGGGQG-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GGGQG-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGHGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GHGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGIGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GIGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGLGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GLGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGMGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GMGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGNGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GNGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGPGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GPGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGQGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GQGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGSGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGRG + Ser-Gly-Gln-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGTGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GTGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGRGVGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GVGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRGYGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GYGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRHAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + HAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRIAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + IAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRLAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + LAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRMAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + MAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRNAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + NAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRPAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + PAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRQAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + QAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRSAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + SAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRTAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + TAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRVAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + VAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGGRYAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + YAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGHRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGHR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGIRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGIR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGKRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGKR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGLRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGLR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGMRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGMR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGNRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGNR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGPRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGPR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGQRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGQR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGRRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGRR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGSRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGSR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGTRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGTR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGVRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGVR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AGYRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGYR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AHGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AHGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AIGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AIGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-ALGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ALGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AMGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AMGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-ANGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ANGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-APGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AQGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AQGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-ASGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ASGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-ATGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ATGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AVGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AVGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-AYGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AYGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Phe-Arg + Ser-Ser-Arg-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-GFSPFRSSRIGIKEEQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-GFSPFR + SSRIGIKEEQ-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-LGMISLMKRPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-LGMISLMK + Arg-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-MISLMKRPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-MISLMK + Arg-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-RPPGFSPFRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-RPPGFSPFR + Gln-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-RPPGFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-RPPGFSPFR + Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
3-(2-furyl)acryloyl-Tyr-Lys-Arg + H2O
3-(2-furyl)acryloyl-Tyr-Lys + Arg
-
-
-
?
acetyl-L-Leu-L-Leu-L-Arg-4-nitroanilide + H2O
acetyl-L-Leu-L-Leu-L-Arg + 4-nitroaniline
-
-
-
-
?
acetyl-L-Leu-L-Lys-L-Arg-4-nitroanilide + H2O
acetyl-L-Leu-L-Lys-L-Arg + 4-nitroaniline
-
-
-
-
?
acetyl-Leu-Leu-Arg-4-nitroanilide + H2O
acetyl-Leu-Leu-Arg + 4-nitroaniline
-
-
-
?
adrenocorticotropic hormone + H2O
SYSMEHFR + WGK + WGKPVGK + VYP
-
-
-
-
?
benzoyl-Gly-Gly-L-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Gly-Gly-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Gly-L-Pro-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-Pro-L-Phe-L-Arg-4-nitroanilide + H2O
benzoyl-L-Pro-L-Phe-L-Arg + 4-nitroaniline
-
-
-
-
?
Benzoyl-Lys 2-naphthylamide + H2O
Benzoyl-Lys + 2-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Gly-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
?
benzyloxycarbonyl-Gly-Gly-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
?
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-Gly-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Gly-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-L-Pro-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-argininyl-L-arginyl-4-nitroanilide + H2O
Nalpha-benzoyl-L-arginyl-L-arginine + 4-nitroaniline
-
-
-
?
benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-lysyl-L-arginyl-4-nitroanilide + H2O
Nalpha-benzoyl-L-lysyl-L-arginine + 4-nitroaniline
-
-
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-L-Val-L-Val-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Val-L-Val-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Lys-4-methylcoumarin 7-amide + H2O
?
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Phe-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
benzyloxycarbonyl-Val-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
?
Boc-Gly-Arg-Arg-4-methylcoumarin 7-amide + H2O
Boc-Gly-Arg-Arg + 7-amino-4-methylcoumarin
-
-
?
Boc-Gly-Lys-Arg-4-methylcoumarin 7-amide + H2O
Boc-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
?
CBZ-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
CBZ-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
weak substrate
-
-
?
DL-Val-Leu-Arg-paranitroanilide + H2O
DL-Val-Leu-Arg + p-nitroaniline
-
-
-
-
?
Glucagon + H2O
?
-
wild type enzyme cleaves Lys12-Tyr13, Arg17-Arg18, and Arg18-Ala19 bonds of glucagon
-
-
?
histone + H2O
?
human histones H1, H2A, H3 and H4, restricted proteolysis
-
?
L-pGlu-Gly-L-Arg-7-amido-4-methylcoumarin + H2O
L-pGlu-Gly-L-Arg + 7-amino-4-methylcoumarin
-
low hydrolytic rate
-
-
?
L-pGlu-L-Arg-L-Thr-L-Lys-L-Arg-7-amido-4-methylcoumarin + H2O
L-pGlu-L-Arg-L-Thr-L-Lys-L-Arg + 7-amino-4-methylcoumarin
-
low hydrolytic rate
-
-
?
L-Pro-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
L-Pro-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-Benzoyl-DL-Arg 4-nitroanilide + H2O
N-Benzoyl-DL-Arg + 4-nitroaniline
-
-
-
-
?
N-Benzyloxycarbonyl-Gly 4-nitrophenyl ester + H2O
N-Benzyloxycarbonyl-Gly + 4-nitrophenol
-
weak
-
-
?
N-benzyloxycarbonyl-Gly-Gly-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-Gly-Gly-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-benzyloxycarbonyl-Lys benzyl ester + H2O
N-benzyloxycarbonyl-Lys + benzyl alcohol
-
-
-
-
?
N-carbobenzoxy-L-Lys 4-nitrophenyl ester + H2O
N-carbobenzoxy-L-Lys + 4-nitrophenol
-
-
-
-
?
N-tosyl-Gly-Pro-Arg-paranitroanilide + H2O
N-tosyl-Gly-Pro-Arg + p-nitroaniline
-
-
-
-
?
Nalpha-benzoyl-Arg-7-amido-4-methylcoumarin + H2O
?
-
68% of the activity with carbobenzoxy-Arg-Arg-4-methylcoumaryl-7-amide
-
-
?
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
Nalpha-benzoyl-DL-argininyl-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
Nalpha-benzyloxycarbonyl-L-Ala-L-Ala-L-Arg-4-nitroanilide + H2O
Nalpha-benzyloxycarbonyl-L-Ala-L-Ala-L-Arg + 4-nitroaniline
-
poor substrate
-
-
?
Nalpha-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O
Nalpha-benzyloxycarbonyl-L-lysine + phenylmethanethiol
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-Phe-L-Arg-4-nitroanilide + H2O
Nalpha-benzyloxycarbonyl-L-Phe-L-Arg + 4-nitroaniline
-
-
-
-
?
RRRPRPPRLPRPRPR + 2 H2O
L-Arg-L-Arg + RPRPPR + LPRPRPR
proline-rich peptide Bac(1-16)
-
-
?
RRRPRPPYLPRPRPPPFF + H2O
L-Arg-L-Arg + RPRPPYLPRPRPPPFF
proline-rich peptide PR-39(1-18)
-
-
?
succinyl-Gly-L-Pro-L-Lys-4-nitroanilide + H2O
succinyl-Gly-L-Pro-L-Lys + 4-nitroaniline
-
poor substrate
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Lys-4-nitroanilide + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Lys + 4-nitroaniline
-
-
-
-
?
succinyl-L-AlaL-Ala-L-Pro-L-Arg-4-nitroanilide + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Arg + 4-nitroaniline
-
-
-
-
?
t-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Arg-Val-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Gln-Gly-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Gly-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Glu-Lys-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Glu-Lys-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Arg-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Val-Leu-Arg + 7-amino-4-methylcoumarin
tert-butoxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin + H2O
tert-butoxycarbonyl-L-Val-L-Leu-L-Lys + 7-amino-4-methylcoumarin
-
best substrate, the hydrolytic activity is observed only in the presence of NaCl and the thiol-reacting reagents dithiothreitol, reduced glutathione, and oxidized glutathione at pH 8.5 (50 mM Tris-HCl)
-
-
?
tert-butyloxycarbonyl-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Glu-Lys-Lys-7-amido-4-methylcoumarin + H2O
?
-
specific substrate for Escherichia coli oligopeptidase B, 20% of the activity with carbobenzoxy-Arg-Arg-4-methylcoumaryl-7-amide
-
-
?
tert-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Val-Gly-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
tosyl-Gly-L-Pro-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
tosyl-Gly-L-Pro-L-Lys-7-amido-4-methylcoumarin + H2O
tosyl-Gly-L-Pro-L-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
2-aminobenzoyl-ADGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ADGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ADGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ADGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AEGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AEGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AEGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AEGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AFGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AFGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AFGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AFGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGDRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGDR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGDRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGDR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGERGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGER + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGERGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGER + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGFRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGFR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGFRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGFR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRDAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + DAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRDAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + DAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGREAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + EAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGREAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + EAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRFAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + FAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRFAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + FAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGADQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GADQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGADQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GADQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAFQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAFQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGAFQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAFQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAHQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAHQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGAHQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAHQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAIQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAIQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAIQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAIQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGALQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GALQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGALQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GALQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAMQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAMQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGAMQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAMQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGANQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GANQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGANQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GANQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGAPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-AGGRGAQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-AGGRGAQQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAQQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGAQQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAQQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGASQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GASQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGASQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GASQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGATQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GATQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGATQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GATQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAVQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAVQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAVQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAVQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGAYQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAYQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGAYQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GAYQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGDGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GDGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGDGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GDGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGEGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GEGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGEGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GEGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGFGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GFGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGFGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GFGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGGGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GGGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGGGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GGGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGGGQG-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GGGQG-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGGGQG-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GGGQG-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
-
?
2-aminobenzoyl-AGGRGHGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GHGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGHGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GHGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGIGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GIGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGIGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GIGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGLGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GLGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGLGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GLGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGMGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GMGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGMGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GMGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGNGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GNGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGNGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GNGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGPGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GPGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGPGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GPGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGQGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GQGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGQGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GQGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGSGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGRG + Ser-Gly-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGSGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGRG + Ser-Gly-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGTGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GTGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
-
-
?
2-aminobenzoyl-AGGRGTGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GTGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
-
-
?
2-aminobenzoyl-AGGRGVGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GVGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGVGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GVGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGYGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GYGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRGYGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + GYGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRHAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + HAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRHAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + HAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRIAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + IAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRIAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + IAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRLAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + LAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRLAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + LAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRMAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + MAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRMAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + MAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRNAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + NAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRNAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + NAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRPAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + PAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRPAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + PAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRQAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + QAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRQAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + QAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRSAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + SAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRSAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + SAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRTAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + TAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRTAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + TAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRVAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + VAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRVAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + VAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRYAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + YAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGGRYAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGGR + YAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGHRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGHR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGHRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGHR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGIRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGIR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGIRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGIR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGKRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGKR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGKRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGKR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGLRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGLR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGLRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGLR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGMRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGMR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGMRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGMR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGNRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGNR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGNRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGNR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGPRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGPR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGPRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGPR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGQRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGQR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGQRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGQR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGRRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGRR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGRRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGRR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGRRRAQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-AGRRRAQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-AGSRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGSR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGSRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGSR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGTRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGTR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGTRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGTR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGVRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGVR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGVRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGVR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGYRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGYR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AGYRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AGYR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AHGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AHGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AHGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AHGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AHKRYSHQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-AHKRYSHQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-AIGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AIGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AIGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AIGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ALGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ALGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ALGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ALGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AMGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AMGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AMGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AMGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AMRRTISQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-AMRRTISQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-ANGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ANGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ANGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ANGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-APGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-APGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-APGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AQGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AQGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AQGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AQGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ASGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ASGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ASGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ASGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ATGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ATGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-ATGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-ATGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AVGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AVGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AVGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AVGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AYGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AYGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-AYGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-AYGR + GAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-FRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-FRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Phe-Arg + Ser-Ser-Arg-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Phe-Arg + Ser-Ser-Arg-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-GFSPFRSSRIGIKEEQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-GFSPFR + SSRIGIKEEQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-GFSPFRSSRIGIKEEQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-GFSPFR + SSRIGIKEEQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-LGMISLMKRPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-LGMISLMK + Arg-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-LGMISLMKRPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-LGMISLMK + Arg-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-MISLMKRPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-MISLMK + Arg-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-MISLMKRPQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-MISLMK + Arg-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-RPPGFSPFRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-RPPGFSPFR + Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-RPPGFSPFRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-RPPGFSPFR + Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-RPPGFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-RPPGFSPFR + Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-RPPGFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-RPPGFSPFR + Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
Atrial natriuretic factor + H2O
?
cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor. The in vitro half-life of atrial natriuretic factor in rat plasma is reduced 300fold in plasma from Trypanosoma evansi infected rodents, which contain high levels of OpdB activity. Oligopeptidase B plays a role in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of atrial natriuretic factor in mammals infected with trypanosoma evansi
-
-
?
Atrial natriuretic factor + H2O
?
cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor
-
-
?
benzoyl-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzoyl-L-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Insulin B-chain + H2O
?
-
cleaves the carboxymethylated B-chain of insulin at the Arg22-Gly23 bond, but after prolonged periods of incubation it is also able to cleave the Tyr16-Leu17 bond
-
-
?
Insulin B-chain + H2O
?
-
cleavage at the carboxyl sides of Arg and Lys residues
-
-
?
Nalpha-benzoyl-DL-Arg-4-nitroanilide + H2O
Nalpha-benzoyl-DL-Arg + 4-nitroaniline
-
-
-
?
Nalpha-benzoyl-DL-Arg-4-nitroanilide + H2O
Nalpha-benzoyl-DL-Arg + 4-nitroaniline
-
-
-
-
?
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
-
-
-
-
?
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
-
-
-
?
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
-
-
-
?
Nalpha-benzoyl-DL-argininyl-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
-
-
-
?
Nalpha-benzoyl-DL-argininyl-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
i.e. BAPNA, substrate of wild-type enzyme PSP, lower activity with truncated enzyme PSP-Chtr
-
-
?
Nalpha-benzoyl-DL-argininyl-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
-
i.e. BAPNA, substrate of wild-type enzyme PSP, lower activity with truncated enzyme PSP-Chtr
-
-
?
Nalpha-benzoyl-DL-argininyl-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
i.e. BAPNA, substrate of wild-type enzyme PSP, lower activity with truncated enzyme PSP-Chtr
-
-
?
Nalpha-benzoyl-L-Arg 2-naphthylamide + H2O
Nalpha-benzoyl-L-Arg + 2-naphthylamine
-
-
-
-
?
Nalpha-benzoyl-L-Arg 2-naphthylamide + H2O
Nalpha-benzoyl-L-Arg + 2-naphthylamine
-
-
-
?
Nalpha-benzoyl-L-Arg 2-naphthylamide + H2O
Nalpha-benzoyl-L-Arg + 2-naphthylamine
-
-
-
?
t-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Arg-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Arg-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Arg-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Arg-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Gly-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Gly-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Gly-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gln-Gly-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gln-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Glu-Lys-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Glu-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Glu-Lys-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Glu-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Glu-Lys-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Glu-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Glu-Lys-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Glu-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Val-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Val-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Val-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
t-butyloxycarbonyl-Val-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
additional information
?
-
-
hydrolyzes peptides with dibasic sites much faster than monobasic substrates, hydrolyzes the peptide bond at lysine and arginine residues
-
?
additional information
?
-
-
specific for substrates with a pair of basic residues at positions P1 and P2
-
?
additional information
?
-
OpdB does not hydrolyse protein substrates with the exception of nominal digestion of the endogenous Escherichia coli enzymes aspartokinase L-homoserine dehydrogenase and aspartokinase III
-
-
?
additional information
?
-
oligopeptidase B can efficiently hydrolyze in vitro cationic antimicrobial peptides up to 30 residues in length, even though they contained several prolines, shortening them to inactive fragments. Two consecutive basic residues are a preferred cleavage site for the peptidase. In the case of a single basic residue, there is no cleavage if proline residues are present in the P1 and P2 positions
-
-
?
additional information
?
-
-
oligopeptidase B can efficiently hydrolyze in vitro cationic antimicrobial peptides up to 30 residues in length, even though they contained several prolines, shortening them to inactive fragments. Two consecutive basic residues are a preferred cleavage site for the peptidase. In the case of a single basic residue, there is no cleavage if proline residues are present in the P1 and P2 positions
-
-
?
additional information
?
-
OPB has a strong preference for lysine or arginine residues at P1. OPB can accommodate several amino acids in the P2âP4 positions, with a preference for glycine in P2, serine, glycine, alanine, asparagine, proline, and threonine in P3, and proline in P4. Bulky hydrophobic groups, such as tyrosine, phenylalanine, and tryptophan, are least preferred
-
-
?
additional information
?
-
-
OPB has a strong preference for lysine or arginine residues at P1. OPB can accommodate several amino acids in the P2âP4 positions, with a preference for glycine in P2, serine, glycine, alanine, asparagine, proline, and threonine in P3, and proline in P4. Bulky hydrophobic groups, such as tyrosine, phenylalanine, and tryptophan, are least preferred
-
-
?
additional information
?
-
no substrate: N-benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
-
no substrate: N-benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
exhibits amidolytic activity exclusively against substrates with basic residues in P1, no activity is observed against H-Arg-4-methylcoumarin 7-amide, H-Leu-4-methylcoumarin 7-amide, H-Lys-4-methylcoumarin 7-amide, benzyloxycarbonyl-Leu-Leu-Glu-beta-nitroanilide, benzyloxycarbonyl-Gly-Gly-Leu-p-nitroanilide, benzyloxycarbonyl-Ala-Ala-Phe-4-methylcoumarin 7-amide, Suc-Ile-Ala-4-methylcoumarin 7-amide, Suc-Gly-Pro-4-methylcoumarin 7-amide, Ac-Tyr-Val-Ala-Asp-p-nitroanilide, Suc-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide
-
?
additional information
?
-
azocasein is a substrate only of truncated enzyme PSP-Chtr, no activity with full-length PSP
-
-
?
additional information
?
-
-
azocasein is a substrate only of truncated enzyme PSP-Chtr, no activity with full-length PSP
-
-
?
additional information
?
-
azocasein is a substrate only of truncated enzyme PSP-Chtr, no activity with full-length PSP
-
-
?
additional information
?
-
-
no hydrolytic activity against the aminopeptidase substrates (4-nitroanilide derivatives of amino acids) and FITC-casein, substrates containing Pro at Xaa positions in the FRETS library are not hydrolyzed
-
-
?
additional information
?
-
-
no hydrolysis of 2-aminobenzoyl acid-LGMISLMKRPPGFSPFRSSRI-NH2-N-(2,4-dinitrophenyl)ethylenediamine
-
?
additional information
?
-
-
the enzyme may be associated with Chagas disease pathogenesis nb yhydrolyzing host proteins and inducing host immune responses
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Atrial natriuretic factor + H2O
?
cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor. The in vitro half-life of atrial natriuretic factor in rat plasma is reduced 300fold in plasma from Trypanosoma evansi infected rodents, which contain high levels of OpdB activity. Oligopeptidase B plays a role in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of atrial natriuretic factor in mammals infected with trypanosoma evansi
-
-
?
additional information
?
-
-
the enzyme may be associated with Chagas disease pathogenesis nb yhydrolyzing host proteins and inducing host immune responses
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Ca2+
-
stimulates amidase and proteolytic activities, maximal activation of 25% at concentrations above 25 mM
Ca2+
-
in presence of Ca2+, efficiency of hydrolysis of substrates with positively charged P2 residues decreases by an order of magnitude due to the worsening in the substrate binding. In the presence of 50 mM Ca2+, no substrate inhibition is observed in the case of acetyl-L-Leu-L-Lys-L-Arg-4-nitroanilide, and the effect was less pronounced for other substrates
Ca2+
calcium ions impede the reverse transition to the closed form. The reduction in the thermal stability of PSP in the presence of Ca2+ can be attributed to the destruction of the salt bridges SB2 and SB3 that takes place as Ca2+ binds to the E494 and D460 residues parxadtaking in bridge formation. Calcixadum ions are a destabilizing factor for all PSP mutant variants, overview
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2R)-2-amino-N-[4-(dimethylaminomethyl)phenyl]propanamide
ZINC 37042497, shows the lowest estimated binding energy by AutoDock program. The selected docking pose is also located close to the catalytic site and interacts through hydrogen bonds with Glu539, Ser614, Arg704, Glu659, and Phe641 residues. As the compound is protonated, it also makes ionic interactions with Glu539 and Glu659. Besides, it also performs hydrophobic contacts with Tyr537, Phe641, Leu655, and Ala615; ZINC 37042497, the compound shows hydrogen bonds with Arg655 and Glu612 residues, and it also forms an ionic interaction with Glu612 and hydrophobic contacts with Leu608, Tyr490, Ala569, and Val656
(3R)-3-amino-N-[3-(1H-tetrazol-5-yl)phenyl]butanamide
ZINC 37608688, located close to the catalytic site. It interacts through hydrogen bonds with Glu612, Pro607, Arg655 and Tyr490, and hydrophobic interactions with His688 and Arg655; ZINC 37608688, the compound forms hydrogen bonds with Tyr537, Pro654, Glu659 and Arg704. Moreover, compound 3 participates on hydrophobic interactions with Ala615, Phe641, Leu653, and Val705
1-(5-hydroxy-pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid
ZINC 19735155; ZINC 19735155, interacts with the binding site through hydrogen bonds with Ser568 and Glu612, Pi-stacking with Tyr490, and salt bridges with Glu612 and Arg567
4-(2-aminoethyl)benzenesulfonylfluoride
non-peptide irreversible serine-peptidase inhibitor
benzoyl-Arg-4-nitroanilide
-
enzyme is inhibited by high concentrations of substrate
bovine basic pancreatic trypsin inhibitor
substrate Nalpha-benzoyl-DL-Arg-4-nitroanilide, competitive
-
diisopropylfluorophosphate
non-peptide irreversible serine-peptidase inhibitor
m-phenanthroline
substrates Nalpha-benzoyl-DL-Arg-4-nitroanilide, acetyl-Leu-Leu-Arg-4-nitroanilide, anticompetitive
methanol
incubation in 20% (v/v) methanol (10-20 h, 4°C) results in partial decomposition of the high molecular weight PSP-GroEL complex with precipitation of denatured chaperonin and a small (no more than 10%) loss of PSP activity
N-ethyl-2-oxo-benzimidazole-5-sulphonamide
ZINC 63887176; ZINC 63887176, interacting through hydrogen bond with Glu659 and Pi-Pi stacking interaction with Tyr537
NaCl
-
loss of almost 50 and 70% of its activity in the presence of 0.2 and 1.0 M NaCl, respectively. Presence of NaCl does not disrupt the dimeric structure
NEM
-
Cys256 is the reactive cysteine residue that mediates OpdB inhibition. Cys256 adducts occlude the P1 substrate-binding site, preventing substrate binding
o-phenanthroline
substrates Nalpha-benzoyl-DL-Arg-4-nitroanilide, acetyl-Leu-Leu-Arg-4-nitroanilide, anticompetitive
p-chloromercuribenzoate
non-peptide irreversible serine-peptidase inhibitor
peptidyl phosphonate alpha-aminoalkyl diphenyl ester
irreversible peptidyl inhibitors
protamines
protamines, basic 30-32 residue peptides that are rich in Arg residues, are potent inhibitors of OpdB
-
tert-butoxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin
-
in the case of added dithiothreitol, reduced glutathione, or oxidized glutathione, a high concentration of the substrate tert-butoxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin inhibits the enzyme activity. By contrast, addition of 1 M NaCl to either dithiothreitol, reduced glutathione, or oxidized glutathione or 1 M NaCl alone prevents substrate inhibition
trans-4-guanidinomethylcyclohexanecarboxylic acid 4-tert-butylphenyl ester
-
IC50: about 0.01 mM. Oligopeptidase B is much more sensitive than oligopeptidase B
ZnCl2
substrate Nalpha-benzoyl-DL-Arg-4-nitroanilide, noncompetitive
3,4-dichloroisocoumarin
non-peptide irreversible serine-peptidase inhibitor
4-(2-aminoethyl)benzenesulfonyl fluoride
irreversible inhibition
4-(2-aminoethyl)benzenesulfonyl fluoride
-
OpdB activity toward tert-butoxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin hydrolysis is inhibited completely by 4 mM pefbloc SC
antipain
antipain-OPBcomplex shows hydrogen bonds with Ser568, Glu612, Glu660, and His688 residues. Besides, it can perform hydrogen bond or ionic interaction with Arg655 residue. Antipain also interacts through hydrogen bonds with Tyr537, Glu659 and Arg704; molecular docking
antipain
-
OpdB activity toward tert-butoxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin hydrolysis is inhibited completely by 0.3 mM antipain
leupeptin
-
OpdB activity toward tert-butoxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin hydrolysis is inhibited completely by 0.05 mM leupeptin
additional information
-
1,10-phenanthroline; EDTA; not: chelating agents; PMSF; several natural trypsin inhibitors; sulfhydryl agents
-
additional information
no inhibition by N-ethylmaleimide and iodoacetic acid. This is consistent with the absence of a cysteine residue at position 256 which is replaced by His
-
additional information
virtual inhibitor screening, molecular docking using the three-dimensional structure model of OPB; virtual inhibitor screening, molecular docking using the three-dimensional structure model of OPB2
-
additional information
virtual inhibitor screening, molecular docking using the three-dimensional structure model of OPB; virtual inhibitor screening, molecular docking using the three-dimensional structure model of OPB2
-
additional information
-
virtual inhibitor screening, molecular docking using the three-dimensional structure model of OPB; virtual inhibitor screening, molecular docking using the three-dimensional structure model of OPB2
-
additional information
no inhibition of wild-type enzyme with iodoacetamide, iodoacetate, N-ethylmaleimide, EDTA, EGTA, bestatin,amastatin, arphamenine A, elastinal, dynorphin A or dynorphin B
-
additional information
treatment of enzyme PSP with immobilized trypsin leads to production of a stable truncated enzyme form (PSP-Tr with about 75 kDa) which lacks 22 C-terminal amino acid residues and completely loses enzymatic activity, presumably because of changes in the nearest environment of His652 of the catalytic triad
-
additional information
-
treatment of enzyme PSP with immobilized trypsin leads to production of a stable truncated enzyme form (PSP-Tr with about 75 kDa) which lacks 22 C-terminal amino acid residues and completely loses enzymatic activity, presumably because of changes in the nearest environment of His652 of the catalytic triad
-
additional information
-
OpdB is not inhibited by E-64 (0.03 mM), pepstain (0.04 mM), EDTA (1 mM), chimostatin (0.2 mM), and phosphoramidon (0.4 mM)
-
additional information
-
reducing reagent such as dithiothreitol has no effect on the inactivation of wild type and mutant OPBs by heat and urea treatment
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NaCl
-
enzymatic activity is markedly enhanced by high NaCl concentration, NaCl affects the P1 preference of OpdB synergistically in a substrate-dependent manner
oxidized glutathione
-
oxidized glutathione enhances OpdB activity and affects the P1 preference of OpdB synergistically in a substrate-dependent manner
reduced glutathione
-
enzymatic activity is markedly enhanced by reduced glutathione at submillimolar level which affects the P1 preference of OpdB synergistically in a substrate-dependent manner
dithiothreitol
-
enzymatic activity is markedly enhanced by dithiothreitol at submillimolar level, which affects the P1 preference of OpdB synergistically in a substrate-dependent manner
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aggressive Periodontitis
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Blister
Proteases are responsible for blister formation in recessive dystrophic epidermolysis bullosa and epidermolysis bullosa simplex.
Breast Neoplasms
Isolation of a protease from the cell-free medium of in vitro cultured mammary carcinoma.
Carcinoma
Isolation of a protease from the cell-free medium of in vitro cultured mammary carcinoma.
Carcinoma
Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1.
Chagas Disease
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
Chagas Disease
The Trypanosoma cruzi virulence factor oligopeptidase B (OPBTc) assembles into an active and stable dimer.
Chronic Periodontitis
Analysis of cultivable Porphyromonas gingivalis with trypsin-like protease enzyme activity and serum antibodies in chronic adult periodontitis.
Chronic Periodontitis
Inhibition of polymorphonuclear leucocyte phagocytosis by Porphyromonas gingivalis culture products in patients with adult periodontitis.
Chronic Periodontitis
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Communicable Diseases
Substrate recognition properties of oligopeptidase B from Salmonella enterica serovar Typhimurium.
Cystic Fibrosis
Sputum trypsin-like protease activity relates to clinical outcome in cystic fibrosis.
Cysts
Detection of trypsin- and chymotrypsin-like proteases using p-nitroanilide substrates after sodium dodecyl sulphate polyacrylamide gel electrophoresis.
Cysts
Human ovarian tumor-associated trypsin. Its purification and characterization from mucinous cyst fluid and identification as an activator of pro-urokinase.
Dental Plaque
Characterization of a trypsin-like protease from the bacterium Bacteroides gingivalis isolated from human dental plaque.
Dental Plaque
Quantification of the bacterium Bacteroides gingivalis in human dental plaque by detection of the trypsin-like protease activity of colonies imprinted on membrane filters.
Herpes Zoster
Immunodetection of acrosin during the acrosome reaction of hamster, guinea-pig and human spermatozoa.
Herpes Zoster
Intactness of zona pellucida does not affect the secretion of a trypsin-like protease from mouse blastocyst.
Herpes Zoster
The zona reaction of hamster and mouse eggs: production in vitro by a trypsin-like protease from cortical granules.
Hypersensitivity
A Novel Serine Protease Inhibitor PE-BBI Ameliorates Cockroach Extract-Mediated Airway Epithelial Barrier Dysfunction.
Hypersensitivity, Delayed
The chemical mediation of delayed hypersensitivity skin reactions. IV. Activation of chemotactic factor precursor by a trypsin-like protease in guinea pig plasma.
Infections
A new Sendai virus vector deficient in the matrix gene does not form virus particles and shows extensive cell-to-cell spreading.
Infections
Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi.
Infections
Transcriptome of an entomophthoralean fungus (Pandora formicae) shows molecular machinery adjusted for successful host exploitation and transmission.
Infections
Virulence of a polymicrobic complex, Treponema denticola and Porphyromonas gingivalis, in a murine model.
Influenza, Human
Electron immunohistochemical localization in rat bronchiolar epithelial cells of tryptase Clara, which determines the pneumotropism and pathogenicity of Sendai virus and influenza virus.
Influenza, Human
Growth activation of influenza virus by trypsin and effect of T-705 (favipiravir) on trypsin-optimized growth condition.
Influenza, Human
Human mucus protease inhibitor in airway fluids is a potential defensive compound against infection with influenza A and Sendai viruses.
Influenza, Human
Professional oral health care by dental hygienists reduced respiratory infections in elderly persons requiring nursing care.
Influenza, Human
The human mucus protease inhibitor and its mutants are novel defensive compounds against infection with influenza A and Sendai viruses.
Influenza, Human
[Proteolysis intensification during influenza virus interaction with plasma membrane of sensitive cells]
Leishmaniasis
Mechanistic insights into mode of actions of novel oligopeptidase B inhibitors for combating leishmaniasis.
Leishmaniasis, Mucocutaneous
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
Leishmaniasis, Visceral
Evaluation of CAAX prenyl protease II of Leishmania donovani as potential drug target: Infectivity and growth of the parasite is significantly lowered after the gene knockout.
Leishmaniasis, Visceral
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
Muscular Dystrophies
Expression of trypsin-like proteases and protease nexin-1 in mdx mouse muscles.
Muscular Dystrophies
Preclinical increase in activity of muscle microsomal trypsin-like protease in murine muscular dystrophy, C57BL/10-mdx.
Muscular Dystrophy, Duchenne
Therapeutic effect of camostat mesilate on Duchenne muscular dystrophy in mdx mice.
Neoplasm Metastasis
Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells.
Neoplasm Metastasis
Surface-enhanced Raman and steady fluorescence study of interaction between antitumoral drug 9-aminoacridine and trypsin-like protease related to metastasis processes, guanidinobenzoatase.
Neoplasms
A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite.
Neoplasms
Detection of trypsin- and chymotrypsin-like proteases using p-nitroanilide substrates after sodium dodecyl sulphate polyacrylamide gel electrophoresis.
Neoplasms
Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells.
Neoplasms
Human ovarian tumor-associated trypsin. Its purification and characterization from mucinous cyst fluid and identification as an activator of pro-urokinase.
Neoplasms
Interaction of the antitumor drug 9-aminoacridine with guanidinobenzoatase studied by spectroscopic methods: a possible tumor marker probe based on the fluorescence exciplex emission.
Neoplasms
Surface-enhanced Raman and steady fluorescence study of interaction between antitumoral drug 9-aminoacridine and trypsin-like protease related to metastasis processes, guanidinobenzoatase.
Periodontal Diseases
Analysis of cultivable Porphyromonas gingivalis with trypsin-like protease enzyme activity and serum antibodies in chronic adult periodontitis.
Periodontitis
Serum-antibodies against the trypsin-like protease of Bacteroides gingivalis in periodontitis.
Prostatic Neoplasms
Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells.
Trypanosomiasis
The Trypanosoma cruzi virulence factor oligopeptidase B (OPBTc) assembles into an active and stable dimer.
Trypanosomiasis, African
A Critical Role for highly Conserved GLU610 Residue of Oligopeptidase B from Trypanosoma Brucei in Thermal Stability.
Trypanosomiasis, African
Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes.
Trypanosomiasis, African
Identification of the reactive cysteine residues in oligopeptidase B from Trypanosoma brucei.
Trypanosomiasis, African
Trypanosome-derived oligopeptidase B is released into the plasma of infected rodents, where it persists and retains full catalytic activity.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0036
2-aminobenzoyl-ADGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.039
2-aminobenzoyl-AEGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.013
2-aminobenzoyl-AGDRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0033
2-aminobenzoyl-AGERGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0057
2-aminobenzoyl-AGGRGADQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.021
2-aminobenzoyl-AGGRGAEQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0063
2-aminobenzoyl-AGHRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0083
2-aminobenzoyl-ANGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.00308
benzoyl-Gly-Gly-L-Arg-7-amido-4-methylcoumarin
pH 8.0, 25°C
0.00776
benzoyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin
pH 8.0, 25°C
0.0034
benzyloxycarbonyl-Gly-Arg-4-methylcoumarin 7-amide
pH 8.0, 37°C
0.0023
benzyloxycarbonyl-Gly-Gly-Arg-4-methylcoumarin 7-amide
pH 8.0, 37°C
0.0012
benzyloxycarbonyl-Gly-L-Arg-L-Arg-7-amido-4-methylcoumarin
21°C, pH not specified in the publication
0.0054
benzyloxycarbonyl-Lys-4-methylcoumarin 7-amide
pH 8.0, 37°C
0.0026
benzyloxycarbonyl-Val-Arg-4-methylcoumarin 7-amide
pH 8.0, 37°C
0.0038
N-benzyloxycarbonyl-Gly-Gly-L-Arg-7-amido-4-methylcoumarin
21°C, pH not specified in the publication
0.00093
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin
21°C, pH not specified in the publication
0.0031
N-benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin
21°C, pH not specified in the publication
2.2
succinyl-L-Ala-L-Ala-L-Pro-L-Lys-4-nitroanilide
-
presence of 50 mM Ca2+, pH 8.0, 25°C
0.0032
2-aminobenzoyl-AFGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0034
2-aminobenzoyl-AFGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0024
2-aminobenzoyl-AGFRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0031
2-aminobenzoyl-AGFRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0015
2-aminobenzoyl-AGGRDAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0045
2-aminobenzoyl-AGGRDAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0014
2-aminobenzoyl-AGGREAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0065
2-aminobenzoyl-AGGREAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0003
2-aminobenzoyl-AGGRFAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0027
2-aminobenzoyl-AGGRFAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0062
2-aminobenzoyl-AGGRGAFQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0097
2-aminobenzoyl-AGGRGAFQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0011
2-aminobenzoyl-AGGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0072
2-aminobenzoyl-AGGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0034
2-aminobenzoyl-AGGRGAHQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0037
2-aminobenzoyl-AGGRGAHQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.011
2-aminobenzoyl-AGGRGAIQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.031
2-aminobenzoyl-AGGRGAIQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0073
2-aminobenzoyl-AGGRGALQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.012
2-aminobenzoyl-AGGRGALQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.003
2-aminobenzoyl-AGGRGAMQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0031
2-aminobenzoyl-AGGRGAMQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0059
2-aminobenzoyl-AGGRGANQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.018
2-aminobenzoyl-AGGRGANQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0011
2-aminobenzoyl-AGGRGAPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0028
2-aminobenzoyl-AGGRGAPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0072
2-aminobenzoyl-AGGRGAPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.013
2-aminobenzoyl-AGGRGAPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0048
2-aminobenzoyl-AGGRGAQQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0088
2-aminobenzoyl-AGGRGAQQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.002
2-aminobenzoyl-AGGRGASQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.012
2-aminobenzoyl-AGGRGASQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.006
2-aminobenzoyl-AGGRGATQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.027
2-aminobenzoyl-AGGRGATQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0091
2-aminobenzoyl-AGGRGAVQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.021
2-aminobenzoyl-AGGRGAVQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0057
2-aminobenzoyl-AGGRGAYQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.011
2-aminobenzoyl-AGGRGAYQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.008
2-aminobenzoyl-AGGRGDGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.012
2-aminobenzoyl-AGGRGDGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.01
2-aminobenzoyl-AGGRGEGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.138
2-aminobenzoyl-AGGRGEGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0021
2-aminobenzoyl-AGGRGFGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.012
2-aminobenzoyl-AGGRGFGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0062
2-aminobenzoyl-AGGRGGGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.014
2-aminobenzoyl-AGGRGGGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0028
2-aminobenzoyl-AGGRGHGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0033
2-aminobenzoyl-AGGRGHGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0032
2-aminobenzoyl-AGGRGIGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.011
2-aminobenzoyl-AGGRGIGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0052
2-aminobenzoyl-AGGRGLGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.024
2-aminobenzoyl-AGGRGLGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.003
2-aminobenzoyl-AGGRGMGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.02
2-aminobenzoyl-AGGRGMGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0046
2-aminobenzoyl-AGGRGNGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0092
2-aminobenzoyl-AGGRGNGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0012
2-aminobenzoyl-AGGRGPGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0098
2-aminobenzoyl-AGGRGPGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0023
2-aminobenzoyl-AGGRGQGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.01
2-aminobenzoyl-AGGRGQGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0032
2-aminobenzoyl-AGGRGSGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0037
2-aminobenzoyl-AGGRGSGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0058
2-aminobenzoyl-AGGRGTGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.013
2-aminobenzoyl-AGGRGTGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.02
2-aminobenzoyl-AGGRGVGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.031
2-aminobenzoyl-AGGRGVGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0039
2-aminobenzoyl-AGGRGYGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0044
2-aminobenzoyl-AGGRGYGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0005
2-aminobenzoyl-AGGRHAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0017
2-aminobenzoyl-AGGRHAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0003
2-aminobenzoyl-AGGRIAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0005
2-aminobenzoyl-AGGRIAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0006
2-aminobenzoyl-AGGRLAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0013
2-aminobenzoyl-AGGRLAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0069
2-aminobenzoyl-AGGRMAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0083
2-aminobenzoyl-AGGRMAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0004
2-aminobenzoyl-AGGRNAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0013
2-aminobenzoyl-AGGRNAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0005
2-aminobenzoyl-AGGRQAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0007
2-aminobenzoyl-AGGRQAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0005
2-aminobenzoyl-AGGRSAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0012
2-aminobenzoyl-AGGRSAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0003
2-aminobenzoyl-AGGRTAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0009
2-aminobenzoyl-AGGRTAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0001
2-aminobenzoyl-AGGRVAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0014
2-aminobenzoyl-AGGRVAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0004
2-aminobenzoyl-AGGRYAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0006
2-aminobenzoyl-AGGRYAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0012
2-aminobenzoyl-AGIRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.01
2-aminobenzoyl-AGIRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0018
2-aminobenzoyl-AGKRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0048
2-aminobenzoyl-AGKRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0019
2-aminobenzoyl-AGLRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0077
2-aminobenzoyl-AGLRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0025
2-aminobenzoyl-AGMRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0029
2-aminobenzoyl-AGMRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.004
2-aminobenzoyl-AGNRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.023
2-aminobenzoyl-AGNRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0082
2-aminobenzoyl-AGPRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.016
2-aminobenzoyl-AGPRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0014
2-aminobenzoyl-AGQRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0059
2-aminobenzoyl-AGQRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0004
2-aminobenzoyl-AGSRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0006
2-aminobenzoyl-AGSRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0019
2-aminobenzoyl-AGTRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0075
2-aminobenzoyl-AGTRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0014
2-aminobenzoyl-AGVRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0039
2-aminobenzoyl-AGVRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0077
2-aminobenzoyl-AGYRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.014
2-aminobenzoyl-AGYRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0032
2-aminobenzoyl-AHGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0035
2-aminobenzoyl-AHGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.002
2-aminobenzoyl-AIGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0044
2-aminobenzoyl-AIGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0013
2-aminobenzoyl-ALGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0026
2-aminobenzoyl-ALGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0009
2-aminobenzoyl-AMGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH8.0, 37°C
0.0059
2-aminobenzoyl-AMGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.001
2-aminobenzoyl-APGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH8.0, 37°C
0.0019
2-aminobenzoyl-APGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0019
2-aminobenzoyl-AQGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0024
2-aminobenzoyl-AQGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0023
2-aminobenzoyl-ASGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0074
2-aminobenzoyl-ASGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0018
2-aminobenzoyl-ATGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0082
2-aminobenzoyl-ATGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0026
2-aminobenzoyl-AVGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.013
2-aminobenzoyl-AVGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0018
2-aminobenzoyl-AYGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.003
2-aminobenzoyl-AYGRGAGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 8.0, 37°C
0.0048
2-aminobenzoyl-Thr-Arg-Arg Phe(NO2)-Ser-Leu-NH2
-
pH 8.0, 25°C, 3 mM
0.0011
3-(2-furyl)acryloyl-Tyr-Lys-Arg
pH 8.0, 37°C, native enzyme
0.0019
3-(2-furyl)acryloyl-Tyr-Lys-Arg
pH 8.0, 37°C, recombinant enzyme
0.457
acetyl-L-Leu-L-Leu-L-Arg-4-nitroanilide
-
presence of 50 mM Ca2+, pH 8.0, 25°C
0.265
acetyl-L-Leu-L-Lys-L-Arg-4-nitroanilide
-
presence of 50 mM Ca2+, pH 8.0, 25°C
0.0044
Ala-Phe-Lys-7-amido-4-methylcoumarin
pH 8.0, 37°C, native enzyme
0.005
Ala-Phe-Lys-7-amido-4-methylcoumarin
pH 8.0, 37°C, recombinant enzyme
0.048
Arg-7-amido-4-methylcoumarin
pH 8.0, 37°C, recombinant enzyme
0.00268
benzoyl-Arg-7-amido-4-methylcoumarin
-
wild-type, pH not specified in the publication, temperature not specified in the publication
0.00564
benzoyl-Arg-7-amido-4-methylcoumarin
-
mutant E524Q, pH not specified in the publication, temperature not specified in the publication
0.00846
benzoyl-Arg-7-amido-4-methylcoumarin
-
mutant E490Q, pH not specified in the publication, temperature not specified in the publication
0.0212
benzoyl-Arg-7-amido-4-methylcoumarin
-
mutant E172Q, pH not specified in the publication, temperature not specified in the publication
0.0411
benzoyl-Arg-7-amido-4-methylcoumarin
-
mutant R689A, pH not specified in the publication, temperature not specified in the publication