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Literature summary for 3.4.21.47 extracted from

  • Lee, M.; Guo, J.P.; McGeer, E.G.; McGeer, P.L.
    Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages (2013), Neurobiol. Aging, 34, 1451-1461.
    View publication on PubMed
Search for more literature for 3.4.21.47

Activating Compound

Activating Compound Comment Organism Structure
properdin properdin (Factor P) binding to the erythrocyte membranes is necessary for C3b to attach and initiate alternative pathway activation Homo sapiens
zymosan it is capable of activating the classical pathway as well as the alternative pathway, when the classical pathway is blocked, mechanism, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Aurin tricarboxylic acid blocks the alternative pathway at a downstream step from C3b attachment. It prevents formation of C3 convertase at the stage where Factor B, attached to the membrane-bound properdin-C3b-Factor B (PC3bB) complex, is cleaved by the protease action of Factor D to form the active C3 convertase enzyme PC3bBb. Activity is restored by the addition of excess Factor D to the serum. But membrane attack complex formation is still blocked by ATA at the stage of C9 addition to C5b678. It has no effect on the classical pathway activation. Binding of aurin tricarboxylic acid to the QPDTIDHDLLLLQLS site blocks the ability of aurin tricarboxylic acid to bind to Factor D protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P00751
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
C3 convertase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function the alternative pathway is activated by zymosan in human serum after blocking the classical pathway activation with either a polyclonal antibody to C4d or with C1 inhibitor. Properdin (Factor P) binding to the erythrocyte membranes is necessary for C3b to attach and initiate alternative pathway activation, regulation, overview Homo sapiens