Application | Comment | Organism |
---|---|---|
medicine | chymase is a potential target for pharmacotherapy for allergic conjunctivitis | Cavia porcellus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ketotifen | - |
Cavia porcellus | |
ONO-WH-236 | 40 and 80 mg/kg used experimentally, potent and selective inhibition of chymase activity | Cavia porcellus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | A7WPL7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | - |
Cavia porcellus | - |
ophthalmic lavage fluid | - |
Cavia porcellus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | - |
Cavia porcellus | N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000016 | - |
pH and temperature not specified in the publication | Cavia porcellus | ONO-WH-236 |
Organism | Comment | Expression |
---|---|---|
Cavia porcellus | chymase activity is increased in ophthalmic lavage fluid immediately after the pollen challenge | up |
General Information | Comment | Organism |
---|---|---|
physiological function | chymase is released from mast cells after antigen challenge, followed by the induction of conjunctivitis symptoms through histamine release from mast cells | Cavia porcellus |