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(25R)-3beta-hydroxycholest-5-en-27-oate + H2O
?
-
-
-
-
?
2-aminobenzoyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Dab(DNP) + H2O
2-aminobenzoyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe + His-Dab(DNP)
-
the enzyme cleaves between Phe and His of modified angiotensin I permitting the release of His-[2-amino-4-(2,3-dinitrophenylamino)-butyrate]
-
-
?
Abz-GIAPFCDLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFCDLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFCMLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFCPLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFCRLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFDMLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFRMLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFSMLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIATFWMLMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-GIEPFSDPMPEQ-EDDnp + H2O
?
-
-
-
-
?
Abz-TPFSALQ-EDDnp + H2O
?
-
-
-
-
?
Abz-TPWSALQ-YNO2 + H2O
?
-
-
-
-
?
acetyltyrosine ethyl ester + H2O
acetyl-Tyr + ethanol
-
-
-
-
?
Ala-Ala-Pro-Leu-4-nitroanilide + H2O
Ala-Ala-Pro-Leu + 4-nitroaniline
Ala-Ala-Pro-Met-4-nitroanilide + H2O
Ala-Ala-Pro-Met + 4-nitroaniline
Ala-Ala-Pro-Phe-4-nitroanilide + H2O
Ala-Ala-Pro-Phe + 4-nitroaniline
angiotensin I + H2O
angiotensin II + ?
angiotensin I + H2O
angiotensin II + His-Leu
angiotensin II + H2O
?
-
-
-
-
?
apo-ornithine-aminotransferase + H2O
?
-
-
-
-
?
atrial natriuretic peptide clearance receptor + H2O
?
-
potential substrate
-
-
?
benzoyl-Arg-4-methylcoumarin 7-amide + H2O
benzoyl-Arg + 4-methylcoumarin 7-amide
-
1.2% of the activity with succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide
-
-
?
benzoyl-Arg-4-nitroanilide + H2O
benzoyl-Arg + 4-nitroaniline
-
no activity with enzyme forms 1D and 1E
-
-
?
benzoyl-L-Tyr-4-nitroanilide + H2O
benzoyl-L-Tyr + 4-nitroaniline
-
activity with enzyme form 1A, no activity with enzyme form 1B, 1C, 1D, 1E
-
-
?
benzyloxycarbonyl-Ala-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Ala + 4-nitrophenyl
-
-
-
-
?
benzyloxycarbonyl-Arg-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Arg + 4-nitrophenol
-
no activity with enzyme form 1B, 1C and 1E
-
-
?
benzyloxycarbonyl-D-Ala-4-nitrophenyl ester + H2O
benzyloxycarbonyl + D-Ala-4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-Phe-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Phe + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-Trp-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Trp + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-Tyr-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Tyr-4-nitrophenyl ester
-
no activity with enzyme form 1C and 1E
-
-
?
big endothelin + H2O
?
-
-
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
Big-endothelin-1 + H2O
endothelin-1 (1-31) + ?
-
-
-
?
cadherin-10 + H2O
?
-
potential substrate
-
-
?
cadherin-13 + H2O
?
-
potential substrate
-
-
?
chemerin + H2O
?
-
mast cell chymase abolishes chemerin activity by the removal of additional amino acids from its C-terminus, this effect is specific to bioactive chemerin (chemerin-157 and to a lesser extent chemerin-156)
-
-
?
cholesteryl ester transfer protein + H2O
?
-
-
-
-
?
cholesteryl ester transfer protein-high density lipoprotein complex + H2O
?
-
-
-
-
?
collagen alpha-1(VI) chain + H2O
?
-
potential substrate
-
-
?
collagen alpha-1(XII) chain + H2O
?
-
potential substrate
-
-
?
collagen type IV + H2O
?
-
-
-
-
?
complement component C3 + H2O
?
-
-
-
-
?
complement component C3a + H2O
?
-
-
-
-
?
connective tissue-activating peptide III + H2O
neutrophil-activating peptide 2 + precursorpeptide
-
i.e. CTAP-II
i.e. NAP-2
-
?
desmocollin-3 + H2O
?
-
potential substrate
-
-
?
DRVWIHPFHL + H2O
?
-
-
-
-
?
DRVWIHPLHL + H2O
?
-
-
-
-
?
DRVWIHPWHL + H2O
?
-
-
-
-
?
endothelin-1 + H2O
31 amino-acid fragment of ET-1 + ?
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
chymase degrades the alpha-, beta- and gamma-chains of fibrinogen, while heparin enhances the degradation of the beta-chain
-
-
?
FITC-Acp-DRVYIHPFHL-DDDDDC-labelled gold nanoparticles + H2O
FITC-Acp + DRVYIHPFHL-DDDDDC-labelld gold nanoparticles
-
-
-
-
?
H2N(CH2)5CO-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
heat shock protein 70 + H2O
?
helodermin + H2O
?
-
-
-
-
?
integrin alpha-11 + H2O
?
-
potential substrate
-
-
?
integrin alpha-3 + H2O
?
-
potential substrate
-
-
?
integrin alpha-7 + H2O
?
-
potential substrate
-
-
?
interleukin 1beta precursor + H2O
?
-
-
-
-
?
interleukin-18 + H2O
?
-
-
-
-
?
interleukin-1beta + H2O
?
-
-
-
-
?
laminin alpha-3 chain + H2O
?
-
potential substrate
-
-
?
laminin alpha-4 chain + H2O
?
-
potential substrate
-
-
?
laminin alpha-5 chain + H2O
?
-
potential substrate
-
-
?
laminin gamma-1 chain + H2O
?
-
potential substrate
-
-
?
latent transforming growth factor-beta + H2O
active transforming growth factor-beta + ?
matrix metalloprotease 8 + H2O
?
-
potential substrate
-
-
?
MeO-succinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
MeO-succinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
-
-
-
?
methoxy-succinyl-Ala-Ala-Pro-Met-p-nitroanilide + H2O
methoxy-succinyl-Ala-Ala-Pro-Met + p-nitroaniline
-
low cleavage efficiency
-
-
?
methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline
methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide + H2O
methoxy-succinyl-Arg-Pro-Tyr + p-nitroaniline
methoxysuccinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
methoxysuccinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxysuccinyl-Arg-Ala-Tyr + 4-nitroaniline
methoxysuccinyl-Arg-Pro-Tyr-4-nitroanilide + H2O
methoxysuccinyl-Arg-Pro-Tyr + 4-nitroaniline
-
-
-
-
?
MR121-CAAPFW + H2O
?
-
-
-
-
?
N-benzoyl-L-Try ethyl ester + H2O
N-benzoyl-L-Try + ethanol
-
-
-
-
?
N-benzoyl-L-Try ethyl ester + H2O
N-benzoyl-L-Tyr + ethanol
-
-
-
-
?
N-benzoyl-L-tyrosine ethyl ester + H2O
?
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline
-
-
-
-
?
N-succinyl-Ala-His-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-His-Pro-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-p-nitroanilide + H2O
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + p-nitroaniline
-
-
-
-
?
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
neurotensin + H2O
?
-
-
-
-
?
pro-collagen + H2O
collagen + ?
-
-
-
?
pro-interleukin-18 + H2O
interleukin-18 fragments
-
cleaves recombinant pro-interleukin-18 at 56-Phe
16 and 20 kDa fragments, the 16 kDa fragment is biologically active
-
?
pro-interleukin-1beta + H2O
interleukin-1beta + ?
-
-
-
?
pro-matrix metalloprotease 2 + H2O
matrix metalloprotease 2 + propeptide
-
-
-
-
?
pro-matrix metalloprotease 9 + H2O
matrix metalloprotease 9 + ?
-
-
-
-
?
pro-matrix metalloprotease 9 + H2O
matrix metalloprotease 9 + propeptide
-
-
-
-
?
pro-matrix metalloproteinase-1 + H2O
matrix metalloproteinase-1 + ?
-
-
-
?
pro-matrix metalloproteinase-3 + H2O
matrix metalloproteinase-3 + ?
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O
?
-
4.6% of the activity with succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide
-
-
?
pro-transforming growth factor-beta + H2O
transforming growth factor-beta + ?
-
-
-
?
pro-transforming growth factor-beta1 + H2O
transforming growth factor-beta1 + ?
-
-
-
?
proangiotensin-12 + H2O
angiotensin II
-
-
-
-
?
procollagen + H2O
collagen + ?
promatrix metalloproteinase 9 + H2O
matrix metalloproteinase 9
-
-
-
-
?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
protocadherin alpha-4 + H2O
?
-
potential substrate
-
-
?
secretory leucocyte protease inhibitor + H2O
?
-
cleaved secretory leucocyte protease inhibitor is a biomarker of chymase activity
-
-
?
secretory leukocyte protease inhibitor + H2O
?
-
the cleavage of recombinant human secretory leukocyte protease inhibitor by human chymase occurres at Leu72-Met73
the cleaved form of SLPI can be used as a biomarker of chymase activity
-
?
succinyl-AAPF-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-AAPF-4-nitroanilide + H2O
succinyl-AAPF + 4-nitroaniline
succinyl-AAPL-4-nitroanilide + H2O
succinyl-AAPL + 4-nitroaniline
low activity
-
-
?
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Met-4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
succinyl-Ala-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Ala-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-epsilon-(2-picolinyl)Lys-Pro-Phe-4-nitroanilide + H2O
?
succinyl-epsilon-(2-picolinyl)Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Gln-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Glu-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Glu-Val-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Gly-Gly-Phe-p-nitroanilide + H2O
succinyl-Gly-Gly-Phe + p-nitroaniline
-
-
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-4-nitroanilide + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-7-amido-4-methylcoumarin + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 7-amino-4-methylcoumarin
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-thiobenzyl ester + H2O
?
-
-
-
-
?
succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
-
-
-
?
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
-
-
-
?
succinyl-Leu-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Leu-Val-Pro-Phe-4-nitroanilide + H2O
?
succinyl-LLVY-4-nitroanilide + H2O
succinyl-LLVY + 4-nitroaniline
succinyl-Lys-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Met-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Met-Val-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Met-Val-Pro-Phe-4-nitroanilide + H2O
succinyl-Met-Val-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Phe-4-nitroanilide + H2O
succinyl-Phe + 4-nitroaniline
-
no activity with enzyme form 1C and 1D
-
-
?
succinyl-Phe-Ala-Phe-4-nitroanilide + H2O
?
succinyl-Phe-epsilon-(2-picolinyl)Lys-4-nitroanilide + H2O
?
succinyl-Phe-Gln-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Glu-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Leu-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Leu-Phe-thiobenzyl ester + H2O
?
-
-
-
-
?
succinyl-Phe-Lys-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Met-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Pro-Thr-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Ser-Phe-4-nitroanilide + H2O
succinyl-Phe-Ser-Phe + 4-nitroaniline
succinyl-Phe-Thr-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Val-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Val-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Phe-Val-Pro-Phe-4-nitroanilide + H2O
succinyl-Phe-Val-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ser-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Thr-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Val-Pro-Leu-4-nitroanilide + H2O
?
succinyl-Val-Pro-Met-4-nitroanilide + H2O
?
succinyl-Val-Pro-Phe-4-nitroanilide + H2O
?
succinyl-Val-Pro-Pro-Phe-SCH2C6H5 + H2O
?
succinyl-Val-Pro-Trp-4-nitroanilide + H2O
?
succinyl-Val-Pro-Tyr-4-nitroanilide + H2O
?
t-butyloxycarbonyl-Ala-Ala-Asp-thiobenzyl ester + H2O
?
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Leu-thiobenzyl ester + H2O
?
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Met-thiobenzyl ester + H2O
?
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Phe-thiobenzyl ester + H2O
?
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Ser-thiobenzyl ester + H2O
?
-
weak activity
-
-
?
t-butyloxycarbonyl-Ala-Ala-Trp-thiobenzyl ester + H2O
?
-
-
-
-
?
t-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarin 7-amide + H2O
?
-
2.6% of the activity with succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide
-
-
?
tissue inhibitor of metalloproteinase-1 + H2O
?
tissue necrosis factor + H2O
?
-
-
-
?
transforming growth factor beta-binding protein + H2O
transforming growth factor beta + protein
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
vasoactive intestinal polypeptide + H2O
?
-
-
-
-
?
additional information
?
-
Ala-Ala-Pro-Leu-4-nitroanilide + H2O
Ala-Ala-Pro-Leu + 4-nitroaniline
-
-
-
?
Ala-Ala-Pro-Leu-4-nitroanilide + H2O
Ala-Ala-Pro-Leu + 4-nitroaniline
-
-
-
-
?
Ala-Ala-Pro-Met-4-nitroanilide + H2O
Ala-Ala-Pro-Met + 4-nitroaniline
-
-
-
?
Ala-Ala-Pro-Met-4-nitroanilide + H2O
Ala-Ala-Pro-Met + 4-nitroaniline
-
-
-
-
?
Ala-Ala-Pro-Phe-4-nitroanilide + H2O
Ala-Ala-Pro-Phe + 4-nitroaniline
negligible activity
-
-
?
Ala-Ala-Pro-Phe-4-nitroanilide + H2O
Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
angiotensin I + H2O
angiotensin II + ?
-
-
-
-
?
angiotensin I + H2O
angiotensin II + ?
-
-
-
-
?
angiotensin I + H2O
angiotensin II + ?
-
-
-
-
?
angiotensin I + H2O
angiotensin II + ?
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
selective hydrolysis at Phe8 to generate bioactive angiotensin II, which can promote cardiac hypertrophy, vascular stenosis, and hypertension
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
the enzyme cleaves Tyr4 and Phe8 at rates of 5.47 and 17800 nM/min. Selective hydrolysis at Phe8 to generate bioactive angiotensin II. Lys40 of chymase contributes to the remarkable preference for angiotensin II generation over destruction
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
hamster chymase cleaves the Phe8-His9 bond of angiotensin I
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
Big endothelin-1 + H2O
?
-
-
-
-
?
Big endothelin-1 + H2O
?
-
-
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
-
chymase cleaves the tyrosine31-glycine32 peptide bond of big-endothelin-1 (1-38)
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
-
chymase cleaves the tyrosine31-glycine32 peptide bond of big-endothelin-1 (1-38)
-
-
?
big-endothelin-1 + H2O
?
-
-
-
-
?
big-endothelin-1 + H2O
?
-
-
-
-
?
big-endothelin-2 + H2O
?
-
-
-
-
?
big-endothelin-2 + H2O
?
-
-
-
-
?
biglycan + H2O
?
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
heat shock protein 70 + H2O
?
-
-
-
?
heat shock protein 70 + H2O
?
-
-
-
?
HMGB1 + H2O
?
-
-
-
?
interleukin-33 + H2O
?
-
-
-
?
interleukin-33 + H2O
?
-
-
-
?
interleukin-33 + H2O
?
-
-
-
-
?
latent transforming growth factor-beta + H2O
active transforming growth factor-beta + ?
-
-
-
-
?
latent transforming growth factor-beta + H2O
active transforming growth factor-beta + ?
-
-
-
-
?
latent transforming growth factor-beta + H2O
active transforming growth factor-beta + ?
-
-
-
-
?
methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline
-
cleavage specificity as determined by substrate phage display P4: (Gly)Val, P3: Gly/Val, P2: Arg > Gly, P1: Phe > Tyr > Trp, P1': Leu > Val, P2': Ser > Glu/Asp > Leu, P3': Leu/Val
-
-
?
methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline
-
-
-
-
?
methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline
-
-
-
-
?
methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline
-
high activity
-
-
?
methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline
-
-
-
-
?
methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide + H2O
methoxy-succinyl-Arg-Pro-Tyr + p-nitroaniline
-
-
-
-
?
methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide + H2O
methoxy-succinyl-Arg-Pro-Tyr + p-nitroaniline
-
-
-
-
?
methoxysuccinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxysuccinyl-Arg-Ala-Tyr + 4-nitroaniline
-
-
-
-
?
methoxysuccinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxysuccinyl-Arg-Ala-Tyr + 4-nitroaniline
-
-
-
-
?
methoxysuccinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxysuccinyl-Arg-Ala-Tyr + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
-
-
-
?
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
-
-
-
?
plasmin + H2O
?
-
-
-
-
?
plasmin + H2O
?
-
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
-
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
-
-
-
-
?
procollagen + H2O
collagen + ?
-
-
-
-
?
procollagen + H2O
collagen + ?
-
-
-
-
?
procollagen + H2O
collagen + ?
-
-
-
-
?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
-
-
-
-
?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
-
-
-
-
?
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
-
-
-
-
?
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
-
-
-
-
?
succinyl-AAPF-4-nitroanilide + H2O
succinyl-AAPF + 4-nitroaniline
-
-
-
-
?
succinyl-AAPF-4-nitroanilide + H2O
succinyl-AAPF + 4-nitroaniline
-
-
-
?
Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O
?
-
26.6% of the activity with succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-epsilon-(2-picolinyl)Lys-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-epsilon-(2-picolinyl)Lys-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-epsilon-(2-picolinyl)Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-epsilon-(2-picolinyl)Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Gln-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Gln-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Glu-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Glu-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Glu-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Glu-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-7-amido-4-methylcoumarin + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 7-amino-4-methylcoumarin
-
-
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-7-amido-4-methylcoumarin + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 7-amino-4-methylcoumarin
-
-
-
?
succinyl-Leu-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Leu-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Leu-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Leu-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-LLVY-4-nitroanilide + H2O
succinyl-LLVY + 4-nitroaniline
-
-
-
-
?
succinyl-LLVY-4-nitroanilide + H2O
succinyl-LLVY + 4-nitroaniline
-
-
-
?
succinyl-Lys-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Lys-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Met-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Met-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Met-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Met-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Ala-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Ala-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-epsilon-(2-picolinyl)Lys-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-epsilon-(2-picolinyl)Lys-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Gln-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Gln-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Glu-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Glu-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Leu-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Leu-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Met-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Met-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Ser-Phe-4-nitroanilide + H2O
succinyl-Phe-Ser-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Phe-Ser-Phe-4-nitroanilide + H2O
succinyl-Phe-Ser-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Phe-Thr-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Thr-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Val-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Val-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Phe-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ser-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ser-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Thr-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Thr-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Thr-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Leu-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Leu-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Met-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Met-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Phe-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Pro-Phe-SCH2C6H5 + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Pro-Phe-SCH2C6H5 + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Trp-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Trp-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Tyr-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Tyr-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Val-Pro-Tyr-4-nitroanilide + H2O
?
-
-
-
-
?
thrombin + H2O
?
-
-
-
-
?
thrombin + H2O
?
-
-
-
-
?
tissue inhibitor of metalloproteinase-1 + H2O
?
-
-
-
-
?
tissue inhibitor of metalloproteinase-1 + H2O
?
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
-
-
-
-
?
Vitronectin + H2O
?
-
-
-
-
?
Vitronectin + H2O
?
-
-
-
?
Vitronectin + H2O
?
-
potential substrate
-
-
?
additional information
?
-
lacks elastase-like preference for P1 Val or Ala, and does not cleave angiotensin I
-
-
?
additional information
?
-
-
lacks elastase-like preference for P1 Val or Ala, and does not cleave angiotensin I
-
-
?
additional information
?
-
-
chymase mediates a major alternative way of angiotensin II production from angiotensin I beside angiotensin converting enzyme in the final step of the renin-angiotensin system. This enzyme is also involved in other physio-pathological processes such as angiogenesis, atherosclerosis and inflammation
-
-
?
additional information
?
-
-
chymase can activate eosinophils to markedly induce the release of chemokines CCL2 (monocyte chemotactic protein-1), CXCL1 (growth-regulated oncogene-alpha), CXCL8 (IL-8), and inflammatory cytokine IL-6, chymase activates ERK, p38 mitogen-activated protein kinase, Janus-activated kinase, Akt and nuclear factor-kappaB in eosinophils by induction of phosphorylation
-
-
?
additional information
?
-
-
chymase only accepts aromatic amino acids in position P1, with a strong preference for Tyr and Phe over Trp. Aliphatic amino acids are preferred in positions P2 to P4 N-terminal of the cleaved bond. In the P1' position C-terminal of the cleaved bond, Ser is clearly over-represented and acidic amino acids Asp and Glu are strongly preferred in the P2' position. In P3', the small aliphatic amino acids Ala, Val and Gly are frequently observed.
-
-
?
additional information
?
-
-
mast cell chymase does not use prochemerin as a substrate
-
-
?
additional information
?
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
-
no activity with succinyl-AAPL-4-nitroanilide, succinyl-AAPI-4-nitroanilide, succinyl-AAPA-4-nitroanilide, succinyl-AAPV-4-nitroanilide, succinyl-VLGR-4-nitroanilide, benzyloxycarbonyl-GPR-4-nitroanilide, acetyl-YVAD-4-nitroanilide, acetyl-VEID-4-nitroanilide, and acetyl-IEPD-4-nitroanilide
-
-
?
additional information
?
-
-
the enzyme does not have a particular preference for any of the three aromatic amino acids, Phe, Tyr and Trp, in the P1 position of substrates and also efficiently cleaves after Leu (with a 3fold lower cleavage activity on Leu compared to substrates with P1 aromatic amino acids). The enzyme has a strong preference for negatively charged amino acids in the P2' position
-
-
?
additional information
?
-
-
shows chymotryptic activity and a strong preference for Trp over Phe and Tyr in the P1 position
-
-
?
additional information
?
-
-
in position P1 a distinct preference for Phe and Ser is observed, in position P2 a high selectivity for Phe, Trp and Leu is detected, while P3 and P4 show specificity for aliphatic amino acids
-
-
?
additional information
?
-
-
no activity with acetyl-Ile-Glu-Pro-Asp-p-nitroanilide, acetyl-Tyr-Val-Ala-Asp-p-nitroanilide, methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide, N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide, H-D-Ile-Pro-Arg-p-nitroanilide, N-(p-tosyl)-Gly-Pro-Arg-p-nitroanilide, N-(p-tosyl)-Gly-Pro-Lys-p-nitroanilide, N-succinyl-Ala-Ala-Ala-p-nitroanilide, methoxy-succinyl-Ala-Ala-Pro-Met-p-nitroanilide, acetyl-Ile-Glu-Pro-Asp-p-nitroanilide, methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide, and N-(p-tosyl)-Gly-Pro-Lys-p-nitroanilide
-
-
?
additional information
?
-
-
prefers Phe in the P1 position (56%), followed by Tyr (28%) and Trp (16%), position P2 is most often occupied by Leu (22%), in positions P3 Val is the preferred amino acid, in position P4 is a preference for Val (20%) and Trp (19%) over other hydrophobic amino acids
-
-
?
additional information
?
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
no activity with succinyl-AAPI-4-nitroanilide, succinyl-AAPA-4-nitroanilide, succinyl-AAPV-4-nitroanilide, succinyl-VLGR-4-nitroanilide, benzyloxycarbonyl-GPR-4-nitroanilide, acetyl-YVAD-4-nitroanilide, acetyl-VEID-4-nitroanilide, and acetyl-IEPD-4-nitroanilide
-
-
?
additional information
?
-
-
no activity with succinyl-AAPI-4-nitroanilide, succinyl-AAPA-4-nitroanilide, succinyl-AAPV-4-nitroanilide, succinyl-VLGR-4-nitroanilide, benzyloxycarbonyl-GPR-4-nitroanilide, acetyl-YVAD-4-nitroanilide, acetyl-VEID-4-nitroanilide, and acetyl-IEPD-4-nitroanilide
-
-
?
additional information
?
-
the enzyme shows preference for aromatic residues (Phe, Tyr, Trp) in the P1 position of substrates and a preference for aliphatic residues in most other substrate positions around the cleavage site. The enzyme also cleaves, albeit with relatively low efficiency, after Leu in the P1 position and exhibits unspecific preference in the P2' position
-
-
?
additional information
?
-
-
the enzyme shows preference for aromatic residues (Phe, Tyr, Trp) in the P1 position of substrates and a preference for aliphatic residues in most other substrate positions around the cleavage site. The enzyme also cleaves, albeit with relatively low efficiency, after Leu in the P1 position and exhibits unspecific preference in the P2' position
-
-
?
additional information
?
-
-
the enzyme from lymphocytes has a substrate preference for tryptophan, a preference distinct from rat mast cell chymase
-
-
?
additional information
?
-
-
the enzyme plays a crucial or significant role in the process of degranulation
-
-
?
additional information
?
-
-
the enzyme plays a role in production of a chemotactic factor for neutrophil leukocytes after degranulation
-
-
?
additional information
?
-
-
proteolytic degradation of low density lipoproteins by mast cell granules results from coordinated action of the two granule-bound enzymes - chymase and carboxypeptidase A. The chymase first cleaves peptides from the apolipoprotein B of low density lipoproteins, and thereafter the carboxypeptidase A cleaves amino acids from the peptides formed
-
-
?
additional information
?
-
-
prefers Phe in the P1 position (59%), followed by Trp (29%) and Tyr (12%), position P2 is most often occupied by Leu (24%) or Arg (22%), in positions P3 and P4 Val is the preferred amino acid
-
-
?
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(6E)-4-[(4-chlorophenyl)sulfonyl]-6-(phenylmethylidene)-1,4-diazepane-2,5-dione
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(6R)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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(6S)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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potent inhibitor
1-(2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide
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1-[(5-fluoro-1-benzothiophen-3-yl)methyl]-3-{[(methoxycarbonyl)(methyl)amino]methyl}-1H-indole-2-carboxylate
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2-(2-[2-[5-amino-2-(3-amino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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2-(2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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i.e. Y40079, novel, potent and orally active chymase inhibitor which would be a useful tool in elucidating the pathophysiological roles of chymase
2-(2-[2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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2-(2-{2-[5-amino-2-(3-amino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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2-(2-{2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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2-(2-{2-[5-amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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2-(2-{2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid diethylamide
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2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid ethyl ester
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2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid ethylamide
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2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-6-carboxylic acid methyl ester
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2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
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2-(5-Acetylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-Amino-6-oxo-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-Amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide
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2-(5-Amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(2-phenethyl)acetamide
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2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-methylacetamide
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2-(5-Benzenesulfonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-Benzoylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-Benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
2-(5-Hydroxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-Mehoxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-Methanesulfonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(5-Oxaloamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-(benzylamino)-4H-3,1-benzoxazin-4-one
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2-(benzyloxycarbonyl-NH(CH2)2CONH)C6H4SO2F
2-(benzyloxycarbonyl-NH(CH2)5CONH)C6H4SO2F
2-(benzyloxycarbonyl-NHCH2CONH)C6H4SO2F
2-(N-benzyl-N-methylamino)-4H-3,1-benzoxazin-4-one
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inhibitor forms a stable acyl-enzyme with half-life of 53 min
2-(N-benzyl-N-methylamino)-6-methyl-4H-3,1-benzoxazin-4-one
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2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one
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inhibitor forms a stable acyl-enzyme with half-life of 25 min
2-amino-4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
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2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
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2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
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2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
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2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
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2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
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2-[2-(4-Fluorophenyl)-5-hydroxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[2-[2-(5-amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
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2-[2-[2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
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2-[2-[2-(5-amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
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2-[2-[2-(5-amino-6-oxo-2-pyridin-4-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
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2-[2-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
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2-[2-[2-[5-amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
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2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
2-[2-[2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
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2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid diethylamide
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2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid ethyl ester
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2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid ethylamide
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2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-6-carboxylic acid methyl ester
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2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid
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TY-51469, specific chymase inhibitor
2-[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]-N-methylacetamide
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2-[5-Amino-2-(3-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-2-(3-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-2-(4-aminophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-2-(4-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxazolo[4,5-b]pyridin-2-yl-2-oxo-ethyl)-acetamide
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2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamide
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2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(2-benzothiazol-2-yl-1-benzyl-2-oxo-ethyl)-acetamide
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2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(4,5-dihydro-oxazol-2-yl)-2-oxo-ethyl]-acetamide
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2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-fluoro-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
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2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
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2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-oxo-2-(5-phenyl-benzooxazol-2-yl)-ethyl]-acetamide
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2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(2-benzoxazolyl)carbonyl]-2-phenylethyl]-acetamide
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2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-aminobenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
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2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
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2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
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2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-hydroxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
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2-[5-Amino-2-(4-hydroxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-2-(4-methoxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-2-(4-nitrophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-6-oxo-2-(3-pyridyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-6-oxo-2-(4-pyridyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-[5-Amino-6-oxo-2-(p-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
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2-{1-[(1,4-dimethyl-1H-indol-3-yl)methyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}hexanoic acid
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2-{2-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
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2-{2-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
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2-{2-[2-(5-Amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
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novel, potent, and orally active inhibitor. Rapidly after oral administration and has satisfactory bioavailability
2-{2-[2-(5-Amino-6-oxo-2-pyridin-4-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
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3-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)-4-methoxybenzonitrile
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3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
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3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
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3-[(3,4-dimethoxyphenyl)sulfonyl]-1-(3,4-dimethylphenyl)imidazoline-2,4-dione
3-[(3-amino-4-carboxy)phenylsulfonyl]-7-chloroquinazorine
3-[5-Amino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)propanamide
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3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
4-({1-[(4-methyl-1-benzothiophen-3-yl)methyl]-1H-benzimidazol-2-yl}sulfanyl)butanoic acid
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4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(2-methylpropoxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
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4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(cyclopentyloxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
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4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
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4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
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4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
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4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
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4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
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4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-[[(propan-2-yl)oxy]imino]-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
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4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(2,5-dimethoxybenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(2-ethoxybenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(2-fluorobenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(2-methoxybenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(4,5-dichloro-2-methoxybenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(5-chloro-2-propoxybenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(5-fluoro-2-methoxybenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(5-hydroxy-2-methoxybenzyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(cyclohexylmethyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(naphthalen-2-ylmethyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-3-ylmethyl)-1,4-diazepane-2,5-dione
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4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-4-ylmethyl)-1,4-diazepane-2,5-dione
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4-[1-(naphthylmethyl)benzimidazol-2-ylthio]butanoic acid
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid
4-[1-[[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid
5-fluoresceinylthiocarbamoyl-Ala-Ala-Met phosphonate diphenyl ester
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5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
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6-(2-butoxy-5-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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6-(2-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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6-(3-chloro-5-fluoro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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6-(3-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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6-(4-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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6-(5-chloro-2-ethoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide
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6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylethyl)-1,4-diazepane-1-carboxamide
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6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylpropyl)-1,4-diazepane-1-carboxamide
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6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(2-phenylethyl)-1,4-diazepane-1-carboxamide
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6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
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6-(5-chloro-2-methoxybenzyl)-N-(2-methyl-1-phenylpropyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
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6-(5-chloro-2-methoxybenzyl)-N-(diphenylmethyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
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6-benzyl-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-methyl-2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one
-
-
alpha1-Aantichymotrypsin
-
Alpha1-proteinase inhibitor
-
antileukoprotease
-
HUSI-I
-
benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone
-
-
benzyloxycarbonyl-Ile-Glu-Pro-Phe-COOCH3
-
-
benzyloxycarbonyl-Leu-Phe-chloromethyl ketone
biotinyl-6-aminocaproyl-6-aminocaproyl-Phe-Leu-Phe-phosphonate phenyl ester
-
-
decanoyl lysophosphatidic acid
-
-
diisopropyl fluorophosphate
dilauroyl phosphatidic acid
-
-
dioleoyl phosphatidic acid
-
-
dipalmitoyl phosphatidic acid
-
-
dipyridyl
-
IC50: above 0.4 mM
distearoyl phosphatidic acid
-
-
fatty acids
-
carbon chain length of 14-22
keto-betaboswellic acid
-
L-1-tosylamide-2-phenyl-ethylchloromethyl ketone
-
-
L-Valyl-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)-L-prolinamide hydrochloride
-
-
lisinopril
-
IC50: above 0.4 mM
methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
-
-
methyl[1-naphthalen-2-yl-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphinic acid
-
-
N-(1-Benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
N-benzyl-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
-
-
N-benzyl-6-(5-chloro-2-methoxybenzyl)-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide
-
-
N-substituted saccharin derivatives
-
N-tosyl-L-phenylalanyl-chloromethyl ketone
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
oleoyl lysophosphatidic acid
-
-
ONO-WH-236
40 and 80 mg/kg used experimentally, potent and selective inhibition of chymase activity
-
palmitoyl lysophosphatidic acid
-
-
phenylmethylsulfonyl fluoride
phosphatidic acid
-
from bovine brain
phosphatidylethanolamine
-
-
platelet factor 4
-
i.e. PF-4, competitive inhibition of enzyme and cathepsin G
-
secretory leucocyte protease inhibitor
-
-
-
secretory leukocyte protease inhibitor
-
-
-
SF2809-I
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0073 mM
SF2809-II
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000041 mM
SF2809-III
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0021 mM
SF2809-IV
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000081
SF2809-V
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000043 mM
SF2809-VI
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000014 mM
soybean tryosin inhibitor
-
-
Soybean trypsin inhibitor
-
substituted 3-phenylsulfonylquinazoline-2,4-dione derivatives
-
-
-
succinyl-Phe-Leu-Phe-phosphonate diphenyl ester
-
-
succinyl-Pro-Leu-Phe-CH2Cl
succinyl-Val-Pro-PheP(OPh)2
succinyl-Val-Pro-PheP-(OPh)2
t-butyloxycarbonyl-Gly-Leu-Phe
[1-(1-benzofuran-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(2,3-dihydro-1H-benzotriazol-1-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
less than 50% inhibition at 0.01 mM
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl](2-phenylethyl)phosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]ethylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phenylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-oxo-2-[[(E)-2-phenylethenyl]amino]ethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-oxo-2-[[(E)-2-phenylethenyl]amino]ethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]ethylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3-chloro-5-fluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3-chlorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(4-fluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(4-methoxyphenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[2-(3,4-difluorophenyl)ethyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonate
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-[[(E)-2-(4-fluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-naphthalen-1-yl-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-[(1-Benzyl-2-hydroxy-2-oxazolo[5,4-b]pyridin-2-yl-ethylcarbamoyl)-methyl]-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester
-
-
[2-(3-[methyl[1-(naphthalen-2-ylcarbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl)-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid
-
-
[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]acetic acid
-
-
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide
-
NK3201
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide
-
NK3201
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
-
NK3201
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
-
NK3201
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
-
NK3201
2-(benzyloxycarbonyl-NH(CH2)2CONH)C6H4SO2F
-
-
2-(benzyloxycarbonyl-NH(CH2)2CONH)C6H4SO2F
-
-
2-(benzyloxycarbonyl-NH(CH2)5CONH)C6H4SO2F
-
-
2-(benzyloxycarbonyl-NH(CH2)5CONH)C6H4SO2F
-
-
2-(benzyloxycarbonyl-NHCH2CONH)C6H4SO2F
-
-
2-(benzyloxycarbonyl-NHCH2CONH)C6H4SO2F
-
-
2-(benzyloxycarbonyl-NHCH2CONH)C6H4SO2F
-
-
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
i.e. Y40079, novel, potent and orally active chymase inhibitor which would be a useful tool in elucidating the pathophysiological roles of chymase
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
i.e. Y40079, novel, potent and orally active chymase inhibitor which would be a useful tool in elucidating the pathophysiological roles of chymase
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
i.e. Y40079, novel, potent and orally active chymase inhibitor which would be a useful tool in elucidating the pathophysiological roles of chymase
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
-
TY-1184
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
-
TY-1184
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
-
TY-1184
3,4-dichloroisocoumarin
-
-
3,4-dichloroisocoumarin
-
-
3-C6H5CONHC6H4SO2F
-
-
3-CF3C6H4SO2F
-
-
3-[(3,4-dimethoxyphenyl)sulfonyl]-1-(3,4-dimethylphenyl)imidazoline-2,4-dione
-
C41
3-[(3,4-dimethoxyphenyl)sulfonyl]-1-(3,4-dimethylphenyl)imidazoline-2,4-dione
-
C41
3-[(3-amino-4-carboxy)phenylsulfonyl]-7-chloroquinazorine
-
SUNC8257
3-[(3-amino-4-carboxy)phenylsulfonyl]-7-chloroquinazorine
-
SUNC8257
3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
-
N-C8257
3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
-
N-C8257
3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
-
N-C8257
4-[1-(naphthylmethyl)benzimidazol-2-ylthio]butanoic acid
-
TEI-E548
4-[1-(naphthylmethyl)benzimidazol-2-ylthio]butanoic acid
-
TEI-E548
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid
-
BCEAB
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid
-
BCEAB
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid
-
BCEAB
4-[1-[[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid
-
-
4-[1-[[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid
-
-
acetyl-Ala-Gly-Phe-CH2Cl
-
-
acetyl-Ala-Gly-Phe-CH2Cl
-
-
alpha1-Aantichymotrypsin
-
-
alpha1-Aantichymotrypsin
-
-
-
alpha1-Aantichymotrypsin
-
-
-
alpha1-Aantichymotrypsin
-
native chymase-heparin proteoglycan complex is largely resistant to inhibition by alpha1-antichymotrypsin
-
alpha1-antitrypsin
-
-
-
alpha1-antitrypsin
-
partial
-
Alpha1-proteinase inhibitor
-
-
-
Alpha1-proteinase inhibitor
-
-
-
antipain
-
-
Aprotinin
-
-
benzyloxycarbonyl-Leu-Phe-chloromethyl ketone
-
-
benzyloxycarbonyl-Leu-Phe-chloromethyl ketone
-
-
C6H5CH2SO3F
-
-
chymostatin
-
-
chymostatin
-
i.e. (S)-1-carboxy-2-(phenylethyl)-carbamoyl-alpha-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal
chymostatin
-
80 ng/ml chymase is significantly inhibited by 0.015 mM chymostatin. 80% inhibition at 0.05 mM
chymostatin
-
[(S)-1-carboxy-2-phenylethyl]-carbamoyl-alpha-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-Gly-X-Phe-al, X can be the amino acid Leu, Val, or Ile, nonspecific chymase inhibitor
chymostatin
-
i.e. (S)-1-carboxy-2-(phenylethyl)-carbamoyl-alpha-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
-
Eglin c
-
potent inhibitor
JNJ-10311795
-
-
JNJ-10311795
i.e. 2-[3-[methyl[1-(2-naphthoyl) piperidin-4-yl]amino]carbonyl-2-naphthyl]-1-(1-naphthyl)-2-oxoethylphosphonic acid
N-substituted saccharin derivatives
-
-
-
N-substituted saccharin derivatives
-
-
-
N-tosyl-L-phenylalanyl-chloromethyl ketone
-
-
N-tosyl-L-phenylalanyl-chloromethyl ketone
-
-
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
-
novel, potent, and orally active inhibitor. Rapidly after oral administration and has satisfactory bioavailability, 32%
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
-
novel, potent, and orally active inhibitor. Rapidly after oral administration and has satisfactory bioavailability
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
-
novel, potent, and orally active inhibitor. Rapidly after oral administration and has satisfactory bioavailability, 17%
NK3201
-
-
NK3201
-
specific inhibitor
oleic acid
-
-
oleic acid
-
reversible inhibitor
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phosphatidylserine
-
-
phosphatidylserine
-
noncompetitive, pseudoirreversible, strong inhibition at pH 8.5-9.5, weak inhibition below pH 7.5
RWJ-355871
-
-
SF2809E
-
-
Soybean trypsin inhibitor
-
complete inhibition at 0.1 mg/ml
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
Bowman-Birk soybean trypsin inhibitor; Kunitz soybean trypsin inhibitor, partial
-
stearic acid
-
-
stearic acid
-
strong inhibition at pH 8.5-9.5, slight inhibition at pH 7.5, no inhibition at pH 6.0
Suc-Val-Pro-PheP-(OPh)2
-
noncompetitive inhibitor
Suc-Val-Pro-PheP-(OPh)2
-
noncompetitive inhibitor
Suc-Val-Pro-PheP-(OPh)2
-
noncompetitive inhibitor
Suc-Val-Pro-PheP-(OPh)2
-
specific chymase inhibitor
succinyl-Pro-Leu-Phe-CH2Cl
-
-
succinyl-Pro-Leu-Phe-CH2Cl
-
-
succinyl-Pro-Leu-Phe-CH2Cl
-
-
succinyl-Val-Pro-PheP(OPh)2
-
-
succinyl-Val-Pro-PheP(OPh)2
-
-
succinyl-Val-Pro-PheP-(OPh)2
-
highly specific and metabolically stable chymase inhibitor with a biological half-life of more than 20 h
succinyl-Val-Pro-PheP-(OPh)2
-
highly-specific and metabolically stable chymase inhibitor with a biological half-life of more than 20 h
succinyl-Val-Pro-PheP-(OPh)2
-
-
SUN-C8007
-
i.e. 3-(3-aminophenylsulfonyl)-7-chloroquinazorine-2,4(1H,3H)-dione
SUN-C8007
-
i.e. 3-(3-aminophenylsulfonyl)-7-chloroquinazorine-2, 4(1H,3H)-dione
SUN-C8257
-
i.e. 3-[(3-amino-4-carboxy)phenylsulfonyl]-7-chloroquinazorine 2,4(1H,3H)-dione
SUN-C8257
-
i.e. 3-[(3-amino-4-carboxy)phenylsulfonyl]-7-chloroquinazorine 2,4(1H,3H)-dione
suramin
-
i.e. 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid
suramin
-
i.e. 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid
t-butyloxycarbonyl-Gly-Leu-Phe
-
-
t-butyloxycarbonyl-Gly-Leu-Phe
-
-
t-butyloxycarbonyl-Gly-Leu-Phe
-
-
TY-51184
-
highly-specific and orally active chymase inhibitor; i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamide-3-methanesulfonylphenyl]oxazole-4-carboxylic acid
TY-51184
-
highly-specific and orally-active chymase inhibitor; i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamide-3-methanesulfonylphenyl]oxazole-4-carboxylic acid
TY-51469
-
i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid; inhibitor with very high affinity (IC50 0.1 nmol/kg) against chymase
TY-51469
-
i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid, TY-51469 has a high specificity for chymase
TY-51469
-
i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid; inhibitor with very high affinity against chymase
TY-51469
specific chymase inhibitor, i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid
TY51184
-
-
Y-40018
-
i.e. 4-[5-amino-2-(3-chlorophenyl)-6-oxo-1,6-dihydropyrimidin-1-ylacetamido]-N-benzyl-2,2-difluoro-3-oxo-5-phenylpentanamide
Y-40018
-
i.e. 4-[5-amino-2-(3-chlorophenyl)-6-oxo-1,6-dihydropyrimidin-1-ylacetamido]-N-benzyl-2,2-difluoro-3-oxo-5-phenylpentanamide
Y-40079
-
i.e. 2-[2-[2-[5-amino-2-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]acetamido]-3-phenylpropionyl]benzoxazole-5-carboxylic acid methyl ester
Y-40079
-
i.e. 2-[2-[2-[5-amino-2-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]acetamido]-3-phenylpropionyl]benzoxazole-5-carboxylic acid methyl ester
Z-Ile-Glu-Pro-Phe-CO2Me
-
-
Z-Ile-Glu-Pro-Phe-CO2Me
-
-
additional information
-
not affected by heparin
-
additional information
-
not inhibited by captopril
-
additional information
-
not inhibited by phosphoramidon
-
additional information
-
both the nonpolar hydrophobic hydrocarbon tails and the polar hydrophilic head are essential for the inhibitory effect of phosphoglycerides
-
additional information
-
endogenous mast cell heparin proteoglycan significantly blocks the inhibition of the enzyme by the serpins alpha1-protease inhibitor and alpha1-antichymotrypsin as well as the inhibition by alpha2-macroglobulin, soybean trypsin inhibitor and plasma. Native chymase-heparin proteoglycan complex is largely resistant to inhibition by alpha1-antichymotrypsin and alpha1-protease inhibitor
-
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0.000005 - 0.0000821
1-(2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide
0.0000261
2-(2-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000143
2-(2-[2-[5-amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000418
2-(2-[2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000595
2-(2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid diethylamide
-
-
0.00003
2-(2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid ethyl ester
-
-
0.0000686
2-(2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid ethylamide
-
-
0.0000563
2-(2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazol-6-carboxylic acid methyl ester
-
-
0.0000226 - 0.000026
2-(2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
0.000105
2-(5-Acetylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.06
2-(5-Amino-6-oxo-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.03
2-(5-Amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide
-
-
0.000389
2-(5-Amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.11
2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(2-phenethyl)acetamide
-
-
0.08
2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-methylacetamide
-
-
0.000369
2-(5-Benzenesulfonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000306
2-(5-Benzoylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000146
2-(5-Benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.0000656
2-(5-Hydroxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000229
2-(5-Mehoxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.00103
2-(5-Methanesulfonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.00447
2-(5-Oxaloamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000005
2-(benzylamino)-4H-3,1-benzoxazin-4-one
-
pH 8.0, 25°C
0.000011
2-(N-benzyl-N-methylamino)-4H-3,1-benzoxazin-4-one
-
pH 8.0, 25°C
0.000017
2-(N-benzyl-N-methylamino)-6-methyl-4H-3,1-benzoxazin-4-one
-
pH 8.0, 25°C
0.000014
2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one
-
pH 8.0, 25°C
0.000237
2-[2-(4-Fluorophenyl)-5-hydroxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.0000289 - 0.0000442
2-[2-[2-(5-amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
0.00000356 - 0.00000557
2-[2-[2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
0.00000262 - 0.0000774
2-[2-[2-(5-amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
0.0000138 - 0.0000435
2-[2-[2-(5-amino-6-oxo-2-pyridin-4-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
0.0000056 - 0.0004
2-[2-[2-[5-amino-2-(3-amino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
0.0000169
2-[2-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.0000185
2-[2-[2-[5-amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.00000112 - 0.0000866
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
0.0000157
2-[2-[2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.00000932
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid diethylamide
-
pH 7.5, 37°C
0.0000102
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid ethyl ester
-
pH 7.5, 37°C
0.00000771
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid ethylamide
-
pH 7.5, 37°C
0.0000102
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-6-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.00000368 - 0.000103
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
0.000124
2-[5-Amino-2-(3-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000141
2-[5-Amino-2-(3-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.00012
2-[5-Amino-2-(4-aminophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000471
2-[5-Amino-2-(4-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.0000606
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxazolo[4,5-b]pyridin-2-yl-2-oxo-ethyl)-acetamide
-
-
0.00385
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamide
-
-
0.000182
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(2-benzothiazol-2-yl-1-benzyl-2-oxo-ethyl)-acetamide
-
-
0.00589
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(4,5-dihydro-oxazol-2-yl)-2-oxo-ethyl]-acetamide
-
-
0.0000907 - 0.0000931
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-fluoro-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
0.0000733 - 0.000489
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
0.0000097 - 0.000174
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-oxo-2-(5-phenyl-benzooxazol-2-yl)-ethyl]-acetamide
0.000305
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.0000133 - 0.000125
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(2-benzoxazolyl)carbonyl]-2-phenylethyl]-acetamide
0.000489
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-aminobenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
pH 7.5, 37°C
0.000012 - 0.000094
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
0.0000169 - 0.00076
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
0.0000097 - 0.00212
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-hydroxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
0.000479
2-[5-Amino-2-(4-hydroxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000487
2-[5-Amino-2-(4-methoxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000547
2-[5-Amino-2-(4-nitrophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000377
2-[5-Amino-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000658
2-[5-Amino-6-oxo-2-(3-pyridyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.00122
2-[5-Amino-6-oxo-2-(4-pyridyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.0000506
2-[5-Amino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000186
2-[5-Amino-6-oxo-2-(p-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.03
3-[5-Amino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)propanamide
-
-
0.000029
6-methyl-2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one
-
pH 8.0, 25°C
0.00008
L-Valyl-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)-L-prolinamide hydrochloride
-
-
0.02
N-(1-Benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
0.000028 - 0.00424
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
0.0000506
[1-[(1-Benzyl-2-hydroxy-2-oxazolo[5,4-b]pyridin-2-yl-ethylcarbamoyl)-methyl]-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester
-
pH 7.5, 37°C
0.000005
1-(2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide
-
pH 7.5, 37°C
0.0000821
1-(2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide
-
-
0.0000226
2-(2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
0.000026
2-(2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000289
2-[2-[2-(5-amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.0000442
2-[2-[2-(5-amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.00000356
2-[2-[2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.00000557
2-[2-[2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.00000262
2-[2-[2-(5-amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.0000774
2-[2-[2-(5-amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000138
2-[2-[2-(5-amino-6-oxo-2-pyridin-4-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.0000435
2-[2-[2-(5-amino-6-oxo-2-pyridin-4-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000056
2-[2-[2-[5-amino-2-(3-amino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0004
2-[2-[2-[5-amino-2-(3-amino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.00000112
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000325
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.0000485
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
i.e. Y40079, novel, potent and orally active chymase inhibitor which would be a useful tool in elucidating the pathophysiological roles of chymase
0.0000639
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000866
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.00000368
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000166
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
pH 7.5, 37°C
0.0000404
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.000103
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
0.0000907
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-fluoro-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
-
pH 7.5, 37°C
0.0000931
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-fluoro-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
-
-
0.0000733
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
-
-
0.000489
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
-
pH 7.5, 37°C
0.0000097
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-oxo-2-(5-phenyl-benzooxazol-2-yl)-ethyl]-acetamide
-
pH 7.5, 37°C
0.000174
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-oxo-2-(5-phenyl-benzooxazol-2-yl)-ethyl]-acetamide
-
-
0.0000133
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(2-benzoxazolyl)carbonyl]-2-phenylethyl]-acetamide
-
pH 7.5, 37°C
0.000125
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(2-benzoxazolyl)carbonyl]-2-phenylethyl]-acetamide
-
-
0.000012
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
pH 7.5, 37°C
0.000094
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
0.0000169
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
pH 7.5, 37°C
0.00076
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
0.0000097
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-hydroxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
pH 7.5, 37°C
0.000183
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-hydroxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
0.00212
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-hydroxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
0.0000131
chymostatin
-
-
0.0000131
chymostatin
-
pH 7.5, 37°C
0.000028
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
-
pH 7.5, 37°C
0.00126
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
-
pH 7.5, 37°C
0.00424
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
-
pH 7.5, 37°C
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0.0015
(6E)-4-[(4-chlorophenyl)sulfonyl]-6-(phenylmethylidene)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.01
(6R)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.000027
(6S)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.0000025
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide
Homo sapiens
-
-
0.000012 - 0.00028
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
0.0003
2-amino-4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.00034 - 0.0005
2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00017 - 0.01
2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.000078
2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0000089
2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.00041 - 0.0142
2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.000037 - 0.000128
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
0.000042
2-[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]-N-methylacetamide
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.000027
3-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)-4-methoxybenzonitrile
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00054 - 0.0043
3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00024 - 0.01
3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00006
3-[(3,4-dimethoxyphenyl)sulfonyl]-1-(3,4-dimethylphenyl)imidazoline-2,4-dione
Homo sapiens
-
-
0.00031 - 0.00068
3-[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
0.0012
4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(2-methylpropoxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0024
4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(cyclopentyloxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.00057
4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.00046 - 0.0018
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
0.00047 - 0.005
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00024
4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.00005
4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.00058
4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-[[(propan-2-yl)oxy]imino]-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.000018
4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.0074
4-[(4-chlorophenyl)sulfonyl]-6-(2,5-dimethoxybenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00018
4-[(4-chlorophenyl)sulfonyl]-6-(2-ethoxybenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00015
4-[(4-chlorophenyl)sulfonyl]-6-(2-fluorobenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00014
4-[(4-chlorophenyl)sulfonyl]-6-(2-methoxybenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.000023
4-[(4-chlorophenyl)sulfonyl]-6-(4,5-dichloro-2-methoxybenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00022
4-[(4-chlorophenyl)sulfonyl]-6-(5-chloro-2-propoxybenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.000026
4-[(4-chlorophenyl)sulfonyl]-6-(5-fluoro-2-methoxybenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.0011
4-[(4-chlorophenyl)sulfonyl]-6-(5-hydroxy-2-methoxybenzyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.01
4-[(4-chlorophenyl)sulfonyl]-6-(cyclohexylmethyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.01
4-[(4-chlorophenyl)sulfonyl]-6-(naphthalen-2-ylmethyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.01
4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-3-ylmethyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.01
4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-4-ylmethyl)-1,4-diazepane-2,5-dione
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.0000062
4-[1-(naphthylmethyl)benzimidazol-2-ylthio]butanoic acid
Homo sapiens
-
-
0.0000054
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid
Homo sapiens
-
-
0.0000054
4-[1-[[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid
Homo sapiens
-
-
0.0041
5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
Homo sapiens
-
-
0.00028
6-(2-butoxy-5-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00011
6-(2-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.0042
6-(3-chloro-5-fluoro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00031
6-(3-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00046
6-(4-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.000083
6-(5-chloro-2-ethoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.0693
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide
Homo sapiens
-
-
0.0053
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylethyl)-1,4-diazepane-1-carboxamide
Homo sapiens
-
-
0.0028
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylpropyl)-1,4-diazepane-1-carboxamide
Homo sapiens
-
-
0.0445
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(2-phenylethyl)-1,4-diazepane-1-carboxamide
Homo sapiens
-
-
0.000034
6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.003
6-(5-chloro-2-methoxybenzyl)-N-(2-methyl-1-phenylpropyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
Homo sapiens
-
-
0.1
6-(5-chloro-2-methoxybenzyl)-N-(diphenylmethyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
Homo sapiens
-
IC50 above 0.1 mM
0.00042
6-benzyl-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.000043 - 0.0125
chymostatin
0.4
dipyridyl
Homo sapiens
-
IC50: above 0.4 mM
0.0000023
JNJ-10311795
Homo sapiens
-
-
0.4
lisinopril
Homo sapiens
-
IC50: above 0.4 mM
0.0026 - 0.0514
methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
0.00021
methyl[1-naphthalen-2-yl-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphinic acid
Homo sapiens
-
-
0.0049
N-benzyl-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
Homo sapiens
-
-
0.1
N-benzyl-6-(5-chloro-2-methoxybenzyl)-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide
Homo sapiens
-
IC50 above 0.1 mM
8
N-tosyl-L-phenylalanyl-chloromethyl ketone
Homo sapiens
-
-
0.000016
ONO-WH-236
Cavia porcellus
pH and temperature not specified in the publication
-
0.000011
RO5066852
Homo sapiens
-
pH 7.4, temperature not specified in the publication
0.0073
SF2809-I
Homo sapiens
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0073 mM
0.000041
SF2809-II
Homo sapiens
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000041 mM
0.0021
SF2809-III
Homo sapiens
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0021 mM
0.000081
SF2809-IV
Homo sapiens
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000081mM
0.000043
SF2809-V
Homo sapiens
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000043 mM
0.000014
SF2809-VI
Homo sapiens
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000014 mM
0.0000028
Suc-Val-Pro-PheP-(OPh)2
Homo sapiens
-
-
0.00036
SUN-C8007
Homo sapiens
-
-
0.00013
SUN-C8257
Homo sapiens
-
-
0.12
suramin
Homo sapiens
-
-
0.000037
TY-51184
Homo sapiens
-
-
0.000007
TY-51469
Homo sapiens
-
-
0.00000262
Y-40018
Homo sapiens
-
-
0.00000485
Y-40079
Homo sapiens
-
-
0.0025
[1-(1-benzofuran-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.00012
[1-(1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.00009
[1-(1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.00092
[1-(1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.00024
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl](2-phenylethyl)phosphinic acid
Homo sapiens
-
-
0.00016
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]ethylphosphinic acid
Homo sapiens
-
-
0.00008
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]methylphosphinic acid
Homo sapiens
-
-
0.0021
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phenylphosphinic acid
Homo sapiens
-
-
0.000029
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.00005
[1-(5-chloro-1-benzothiophen-3-yl)-2-oxo-2-[[(E)-2-phenylethenyl]amino]ethyl]methylphosphinic acid
Homo sapiens
-
-
0.00006
[1-(5-chloro-1-benzothiophen-3-yl)-2-oxo-2-[[(E)-2-phenylethenyl]amino]ethyl]phosphonic acid
Homo sapiens
-
-
0.000165
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]ethylphosphinic acid
Homo sapiens
-
-
0.000058
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
Homo sapiens
-
-
0.000011
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.000017
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3-chloro-5-fluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
Homo sapiens
-
-
0.0000035
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3-chlorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
Homo sapiens
-
-
0.000066
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(4-fluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.00028
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(4-methoxyphenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.0104
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[2-(3,4-difluorophenyl)ethyl]amino]-2-oxoethyl]methylphosphinic acid
Homo sapiens
-
-
0.00001
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]methylphosphinic acid
Homo sapiens
-
-
0.000013
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.000021
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
Homo sapiens
-
-
0.000016
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-[[(E)-2-(4-fluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.00019
[1-naphthalen-1-yl-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.0000045
[2-(3-[methyl[1-(naphthalen-2-ylcarbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl)-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid
Homo sapiens
-
-
0.000039
[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]acetic acid
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.000012
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
Canis lupus familiaris
-
-
0.000025
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
Homo sapiens
-
-
0.00028
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
Mesocricetus auratus
-
-
0.00034
2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.0005
2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.00017
2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.0003
2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.01
2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
IC50 above 0.01 mM
0.00041
2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.0025
2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.0061
2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.0142
2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.000037
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
Homo sapiens
-
-
0.000058
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
Canis lupus familiaris
-
-
0.000128
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
Mesocricetus auratus
-
-
0.00054
3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.0043
3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.00024
3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.01
3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
IC50 above 0.01 mM
0.00031
3-[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
Homo sapiens
-
-
0.00068
3-[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
Mesocricetus auratus
-
-
0.00046
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
Homo sapiens
-
-
0.0018
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
Homo sapiens
-
-
0.00047
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.00063
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.005
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
Homo sapiens
-
-
0.000043
chymostatin
Homo sapiens
-
in 50 mM Tris/HCl buffer (pH 7.5) containing 1 M NaCl and 0.01% Triton X-100
0.00024
chymostatin
Homo sapiens
-
-
0.0125
chymostatin
Homo sapiens
-
at pH 8.0 and 37°C
0.0026
methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
Homo sapiens
-
-
0.0514
methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
Homo sapiens
-
-
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