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Literature summary for 3.4.21.39 extracted from

  • Piliponsky, A.M.; Chen, C.C.; Rios, E.J.; Treuting, P.M.; Lahiri, A.; Abrink, M.; Pejler, G.; Tsai, M.; Galli, S.J.
    The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis (2012), Am. J. Pathol., 181, 875-886.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tissue necrosis factor + H2O Mus musculus
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 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P21812
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-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tissue necrosis factor + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
mast cell protease 4
-
 Mus musculus
MCP-4
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 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice exhibit higher numbers of peritoneal neutrophils and increased acute kidney injury after cecal ligation and puncture, and also have significantly higher mortality after this procedure Mus musculus
physiological function MCP-4 can enhance survival after cecal ligation and puncture at least in part by limiting detrimental effects of tissue necrosis factor Mus musculus