Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biotinyl-KKQ20KK + H2O | - |
Mus musculus | ? | within the lysosome, the major endoprotease, cathepsin L, carries out an initial attack within the polyglutamine repeat, which generates new C termini, facilitating the actions of the carboxypeptidase cathepsin Z. Extracts containing both cathespin L and Z show multiple cleavages within the polyglutamine sequence of biotinyl-KKQ20KK, generating a variety of fragments, including biotinyl-KKQ4,biotinyl-KKQ8, Q12KK, andQ16KK | ? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin Z | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | RNAi for cathepsins L and Z confirms that they are critical in degrading polyglutamine-rich proteins (expanded huntingtin exon 1) but not other types of aggregation-prone proteins | Mus musculus |