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Literature summary for 3.2.1.163 extracted from

  • Haeuw, J.F.; Grard, T.; Alonso, C.; Strecker, G.; Michalski, J.C.
    The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity (1994), Biochem. J., 297, 463-466.
No PubMed abstract available
Search for more literature for 3.2.1.163

Inhibitors

Inhibitors Comment Organism Structure
swainsonine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ stimulates Rattus norvegicus
Zn2+ stimulates Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the core-specific lysosomal enzyme is involved in N-glycan catabolism, Man-alpha(l-6)linkage hydrolysis depends on the action of endoglycosidases, namely aspartyl-N-acetyl-beta-D-glucosaminidase and endo-N-acetyl-beta-D-glucosaminidase, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Man-alpha(1-3)[Man-alpha(l-6)]Man-beta(1-4)GlcNAc-beta(1-4)GlcNAc-beta(1-N)Asn + H2O i.e. Man3GlcNAc2Asn, degradation in concert with endoglycosidases, low activity, overview Rattus norvegicus ?
-
 ?
Man-alpha(1-6)Man-alpha(1-4)GlcNAc-beta(1-4)GlcNAc-beta(1-N)Asn + H2O i.e. Man2GlcNAc2Asn, degradation in concert with endoglycosidases, low activity, overview Rattus norvegicus ?
-
 ?
additional information the core-specific lysosomal enzyme is involved in N-glycan catabolism, Man-alpha(l-6)linkage hydrolysis depends on the action of endoglycosidases, namely aspartyl-N-acetyl-beta-D-glucosaminidase and endo-N-acetyl-beta-D-glucosaminidase, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
core-specific lysosomal alpha (1-6)-mannosidase
-
 Rattus norvegicus
lysosomal alpha 1,6-mannosidase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
 assay at Rattus norvegicus