Literature summary for 3.1.3.66 extracted from

Li, D.; Yang, J.; Ma, H.; Sun, C.; Feng, R.
Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway (2018), J. Cell. Biochem., 119, 9899-9909 .

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Application

Application	Comment	Organism
medicine	INPP4B is low expressed in osteosarcoma tissues and in osteosarcoma cell lines. INPP4B overexpression significantly decreases cell viability and induces apoptosis in SaOS2 and U2OS cells. Combination of INPP4B overexpression and poly-ADP ribose polymerase inhibitor rucaparib declines Myc, cyclin E1 and cyclin D1 expressions, enhances Bad, Bax, and cleaves caspase3 expressions, and blocks PI3K/AKT signal pathway in SaOS2 and U2OS cells. Combination of INPP4B overexpression and rucaparib inhibits tumor formation in vivo	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15327	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SAOS-2 cell	-	Homo sapiens	-
U2-OS cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
INPP4B	-	Homo sapiens

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Release 2023.1 (January 2023)