Literature summary for 3.1.3.66 extracted from

Aich, J.; Mabalirajan, U.; Ahmad, T.; Agrawal, A.; Ghosh, B.
Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation (2012), Nat. Commun., 3, 877.

Search for more literature for 3.1.3.66

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
INPP4A	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	lung-specific knockdown of INPP4A by siRNA induces spontaneous inflammation in mice possibly by activating the PI3K-Akt pathway. In mice with experimental asthma, further knockdown of INPP4A by siRNA leads to a severe asthma phenotype, whereas overexpression of INPP4A reverses airway hyper-responsiveness (AHR) and airway inflammation in allergic mice	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)