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Literature summary for 3.1.1.7 extracted from

  • Geissler, T.; Brandt, W.; Porzel, A.; Schlenzig, D.; Kehlen, A.; Wessjohann, L.; Arnold, N.
    Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus (2010), Bioorg. Med. Chem., 18, 2173-2177.
    View publication on PubMed
Search for more literature for 3.1.1.7

Application

Application Comment Organism
drug development AChE is a target for development of improved inhibitots in therapy of Alzheimer's disease Homo sapiens
medicine inhibition of acetylcholinesterase and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for Alzheimer's disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
10-hydroxy-infractopicrin isolated from Cortinarius infractus, inhibits acetylcholinesterase, but does not inhibit butyrylcholinesterase Homo sapiens
galanthamine inhibits also butyrylcholinesterase Homo sapiens
infractopicrin isolated from Cortinarius infractus, inhibits acetylcholinesterase, but does not inhibit butyrylcholinesterase Homo sapiens
additional information inhibitors docking studies, enzyme binding structure and molecular modeling, overview Homo sapiens
physostigmine inhibits also butyrylcholinesterase Homo sapiens
tacrine inhibits also butyrylcholinesterase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information bioassay for inhibition of fibril formation, i.e. Thioflavin T assay Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00071
-
-
 Homo sapiens tacrine
0.0026
-
-
 Homo sapiens physostigmine
0.0087
-
-
 Homo sapiens galanthamine
0.0097
-
-
 Homo sapiens infractopicrin
0.0127
-
-
 Homo sapiens 10-hydroxy-infractopicrin