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1,1-dimethyl-4-acetylthiomethylpiperidinium + H2O
?
i.e. MATP+, paper spray mass spectrometry is used to monitor the activity of acetylcholinesterase, both in-solution and on modified hydrophobic paper surface. Hydrophobic paper surfaces are prepared using vaporized trichloro(3,3,3-trifluoropropyl)silane. In both approaches, mixtures of diluted human whole blood with and without inhibitor ethyl ((2-[bis(propan-2-yl)amino]ethyl)sulfanyl)(methyl)phosphonate (VX) are mixed with a non-endogenous AChE specific substrate, 1,1-dimethyl-4-acetylthiomethylpiperidinium (MATP+). Formation of the cleaved MATP+ product is monitored over time and compared to MATP+ to determine relative AChE activity. This on-substrate assay is effective at determining AChE activity and identifying the toxicant, while determination of AChE activity in-solution proceeds at a slower rate. Method evaluation, overview
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
a chromogenic substrate for detection of erythrocyte acetylcholinesterase activity
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
2,6-dichlorophenolindophenol acetate + H2O
2,6-dichlorophenolindophenol + acetate
2,6-dichlorophenolindophenol acetate computational molecular docking study using the enzyme's crystal structure, PDB ID 4YE7
-
?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
2-methoxyacetylthiocholine + H2O
thiocholine + 2-methoxyacetate
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
-
weak substrate
-
?
3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
-
weak substrate
-
?
3-(acetamido)-N,N,N-trimethylanilinium + H2O
?
-
slow hydrolysis
-
?
3-(acetamido)-N,N,N-trimethylanilinum + H2O
?
-
ATMA
-
?
3-methylbutyrylthiocholine + H2O
thiocholine + 3-methylbutyrate
6-monoacetylmorphine + H2O
morphine + acetate
-
-
?
acetyl(beta-methyl)thiocholine iodide + H2O
1-methyl(thio)choline iodide + acetate
-
-
-
?
acetyl-(beta-methyl)thiocholine + H2O
(beta-methyl)thiocholine + acetate
-
-
-
?
acetyl-(beta-methyl)thiocholine iodide + H2O
acetate + methylthiocholine iodide
-
-
-
?
acetyl-beta-methyl-thiocholine + H2O
beta-methyl-thiocholine + acetate
-
-
-
?
acetyl-beta-methylcholine + H2O
beta-methylcholine + acetate
acetyl-beta-methylcholine + H2O
methylcholine + acetate
-
-
-
?
acetyl-beta-methylthiocholine + H2O
? + acetate
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
acetyl-homo-thiocholine + H2O
?
acetyl-[beta-methyl]thiocholine + H2O
acetate + [beta-methyl]thiocholine
acetylcholine + H2O
acetate + choline
acetylcholine + H2O
choline + acetate
acetylcholine + H2O
thiocholine + acetate
-
-
-
?
acetylcholine chloride + H2O
acetate + choline chloride
-
-
-
?
acetylcholine chloride + H2O
choline chloride + acetate
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
acetylthiocholine + H2O
acetate + thiocholine
acetylthiocholine + H2O
thiocholine + acetate
acetylthiocholine chloride + H2O
acetate + thiocholine chloride
-
-
-
?
acetylthiocholine chloride + H2O
thiocholine chloride + acetate
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
acetylthiocholine iodide + H2O
thiocholine + acetate
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
alkyl methylphosphonfluoridate + H2O
?
-
oxime-assisted catalysis of organophosphates by AChE, mechanism, reaction system, overview
-
?
alpha-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
benzoylthiocholine + H2O
choline + benzoate
-
13% and 9% activity compared to acetylthiocholine with isozymes AChEA and AChEB, respectively
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
benzoylthiocholine iodide + H2O
thiocholine iodide + benzoate
-
22.2% activity compared to acetylthiocholine
-
?
butylthiocholine + H2O
thiocholine + butanol
butyryl choline + H2O
butyrate + choline
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
butyrylthiocholine + H2O
thiocholine + butanoate
butyrylthiocholine + H2O
thiocholine + butyrate
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
carbachol + H2O
?
-
slow hydrolysis
-
?
cyclopentylcarbonylthiocholine + H2O
thiocholine + cyclopentanecarboxylate
cyclopropylcarbonylthiocholine + H2O
thiocholine + cyclopropanecarboxylate
diisopropyl phosphofluoridate + H2O
?
edrophonium chloride + H2O
?
-
-
-
?
heroin + H2O
6-monoacetylmorphine + acetate
-
-
?
hexanoylthiocholine + H2O
thiocholine + hexanoate
indophenylacetate + H2O
indophenol + acetate
isobutyrylthiocholine + H2O
thiocholine + isobutyrate
Leu + Arg
Tyr + Gly
-
-
-
?
Leu + Met
substance P
-
-
-
?
methylthiocholine + H2O
thiocholine + methanol
N-2-acetoxyethyl-N-methylpiperidinium + H2O
?
paraoxon + H2O
diethylphosphate + 4-nitrophenol
pentanoylthiocholine + H2O
thiocholine + pentanoate
Phe + Leu
Gly + Gly + Gly
-
-
-
?
phenylacetylthiocholine + H2O
thiocholine + phenylacetate
pivaloylthiocholine + H2O
thiocholine + pivalate
propionylcholine chloride + H2O
choline chloride + propionate
-
-
-
?
propionylcholine iodide + H2O
choline iodide + propionate
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
propionylthiocholine + H2O
thiocholine + propanoate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
propionylthiocholine chloride + H2O
thiocholine chloride + propionate
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
propylthiocholine + H2O
thiocholine + propanol
S-acetylthiocholine + H2O
acetate + thiocholine
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
S-butyrylthiocholine + H2O
thiocholine + butyrate
S-butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
-
-
?
succinyldicholine + H2O
2 choline + succinate
-
-
?
[leu5] enkephalin + H2O
Tyr + Leu
-
-
-
?
[met5] enkephalins + H2O
Tyr + Met
-
-
-
?
additional information
?
-
2,6-dichloro-3'-methylindophenylacetate + H2O

2,6-dichloro-3'-methylindophenol + acetate
-
weak substrate
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
-
-
-
?
2,6-dichlorophenolindophenylacetate + H2O

2,6-dichlorophenolindophenol + acetate
-
-
-
?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
-
-
-
?
2-methoxyacetylthiocholine + H2O

thiocholine + 2-methoxyacetate
-
recombinant enzyme shows about 12% activity compared to acetylthiocholine
-
?
2-methoxyacetylthiocholine + H2O
thiocholine + 2-methoxyacetate
recombinant enzyme shows about 65% activity compared to acetylthiocholine
-
?
3-methylbutyrylthiocholine + H2O

thiocholine + 3-methylbutyrate
-
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
?
3-methylbutyrylthiocholine + H2O
thiocholine + 3-methylbutyrate
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
acetyl-beta-methylcholine + H2O

beta-methylcholine + acetate
-
-
-
?
acetyl-beta-methylcholine + H2O
beta-methylcholine + acetate
-
-
-
?
acetyl-beta-methylthiocholine + H2O

beta-methylthiocholine + acetate
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
-
preferred substrate
-
?
acetyl-homo-thiocholine + H2O

?
-
recombinant enzyme shows less than 10% activity compared to acetylthiocholine
-
?
acetyl-homo-thiocholine + H2O
?
recombinant enzyme shows less than 10% activity compared to acetylthiocholine
-
?
acetyl-[beta-methyl]thiocholine + H2O

acetate + [beta-methyl]thiocholine
-
-
-
?
acetyl-[beta-methyl]thiocholine + H2O
acetate + [beta-methyl]thiocholine
-
-
-
?
acetylcholine + H2O

?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O
?
-
-
-
?
acetylcholine + H2O
?
-
-
-
?
acetylcholine + H2O
?
-
-
-
?
acetylcholine + H2O
?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O
?
-
-
-
?
acetylcholine + H2O
?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O
?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O
?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O
?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O
?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O
?
-
synaptic transmission, termination of impulse transmission at cholinergic synapses by hydrolysis
-
?
acetylcholine + H2O
?
-
inactivation of transmitter substance operating in cholinergic neurotransmission
-
?
acetylcholine + H2O

acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
691156, 692653, 692785, 703783, 707691, 707743, 707747, 708106, 708130, 708139, 708326, 708829, 709593 -
?
acetylcholine + H2O
acetate + choline
-
acetylcholinesterase plays in vivo a key role in cholinergic transmission by catalysing the rapid hydrolysis of the neurotransmitter acetylcholine into acetate and choline
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O
acetate + choline
-
-
-
?
acetylcholine + H2O

choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
677724, 682017, 713996, 714110, 714704, 716950, 716958, 728999, 729173, 729380, 729388, 729391, 730993, 730995, 730996, 730997, 749984 -
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of neurotransmitter acetylcholine into choline and acetate
-
?
acetylcholine + H2O
choline + acetate
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview
-
?
acetylcholine + H2O
choline + acetate
-
fast hydrolysis
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
esteratic and anionic subsites act together to achieve substrate binding specificity
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
preferred substrate
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which are allosterically related and involved in substrate inhibition, structure-function relationship analysis, overview
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine + H2O
choline + acetate
-
-
-
?
acetylcholine iodide + H2O

acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylcholine iodide + H2O
acetate + choline iodide
-
-
-
?
acetylthiocholine + H2O

acetate + thiocholine
-
most efficiently hydrolyzed substrate
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
most efficiently hydrolyzed substrate
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
most efficiently hydrolyzed substrate
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
most efficiently hydrolyzed substrate
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
?
acetylthiocholine + H2O

thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
isoform AChE2 has approximately 2500fold greater catalytic efficiency toward acetylthiocholine and butyrylthiocholine than isoform AChE1
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
acetylthiocholine iodide
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
best substrate for both isozymes AChEA and AChEB
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
664578, 677724, 677953, 678096, 678101, 678228, 678404, 679202, 680235, 681108, 682017, 682920, 682921, 714852, 728999, 729388, 729391, 730993, 730995, 730996, 730997, 749984 -
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
100% activity
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
fast hydrolysis
-
?
acetylthiocholine + H2O
thiocholine + acetate
activity of AChE is determined by Ellman's method using acetylthiocholine iodide as a substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
substrate is acetylthiocholine iodide
-
?
acetylthiocholine + H2O
thiocholine + acetate
substrate is acetylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
substrate is acetylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
100% activity
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
preferred substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
preferred substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
preferred substrate, isozyme PpAChE5 shows the highest catalytic efficiency (Vmax/KM) for substrate acetylthiocholine, which is about 5.4 and 8.6 times compared to butyrylthiocholine and propionylthiocholine, respectively
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
preferred substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
best substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
activity of AChE is determined by Ellman's method using acetylthiocholine iodide as a substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
activity of AChE is determined by Ellman's method using acetylthiocholine iodide as a substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
i.e. acetyl-beta-(methyl)thiocholine iodide (AbMSCh) as substrate
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
catalytic residues are Ser200 and Trp84
-
?
acetylthiocholine + H2O
thiocholine + acetate
substrate is acetylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine iodide + H2O

acetate + thiocholine iodide
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
acetylthiocholine iodide + H2O

thiocholine + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine + acetate
-
-
-
?
acetylthiocholine iodide + H2O

thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
highly preferred substrate
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
preferred substrate
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
-
?
alpha-naphthyl acetate + H2O

alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
aryl-acyl-amides + H2O

?
-
-
-
?
aryl-acyl-amides + H2O
?
-
-
-
?
aryl-acyl-amides + H2O
?
-
-
-
?
aryl-acyl-amides + H2O
?
-
-
-
?
benzoylthiocholine + H2O

thiocholine + benzoate
-
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
recombinant enzyme shows about 1% activity compared to acetylthiocholine
-
?
butylthiocholine + H2O

thiocholine + butanol
-
-
-
?
butylthiocholine + H2O
thiocholine + butanol
-
-
-
?
butyrylthiocholine + H2O

butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
?
butyrylthiocholine + H2O

thiocholine + butanoate
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butanoate
-
-
very bad substrate
?
butyrylthiocholine + H2O

thiocholine + butyrate
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
isoform AChE2 has approximately 2500fold greater catalytic efficiency toward acetylthiocholine and butyrylthiocholine than isoform AChE1
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
48% and 41% activity compared to acetylthiocholine with isozymes AChEA and AChEB, respectively
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
recombinant enzyme shows about 3% activity compared to acetylthiocholine
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
worst substrate
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
native enzyme shows about 50% activity and recombinant enzyme shows about 45% activity compared to acetylthiocholine
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
very low activity
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
lower activity
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
low activity
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
?
butyrylthiocholine iodide + H2O

thiocholine iodide + butyrate
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
low activity
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
41.7% activity compared to acetylthiocholine
-
?
cyclopentylcarbonylthiocholine + H2O

thiocholine + cyclopentanecarboxylate
-
recombinant enzyme shows about 4% activity compared to acetylthiocholine
-
?
cyclopentylcarbonylthiocholine + H2O
thiocholine + cyclopentanecarboxylate
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
cyclopropylcarbonylthiocholine + H2O

thiocholine + cyclopropanecarboxylate
-
recombinant enzyme shows about 4% activity compared to acetylthiocholine
-
?
cyclopropylcarbonylthiocholine + H2O
thiocholine + cyclopropanecarboxylate
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
diisopropyl phosphofluoridate + H2O

?
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
?
diisopropyl phosphofluoridate + H2O
?
-
mutant G117H, no activity with the wild-type enzyme
-
?
echothiophate + H2O

?
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
?
echothiophate + H2O
?
-
mutant G117H, no activity with the wild-type enzyme
-
?
hexanoylthiocholine + H2O

thiocholine + hexanoate
-
recombinant enzyme shows about 6% activity compared to acetylthiocholine
-
?
hexanoylthiocholine + H2O
thiocholine + hexanoate
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
indophenylacetate + H2O

indophenol + acetate
-
-
-
?
indophenylacetate + H2O
indophenol + acetate
-
-
-
?
isobutyrylthiocholine + H2O

thiocholine + isobutyrate
-
recombinant enzyme shows about 2% activity compared to acetylthiocholine
-
?
isobutyrylthiocholine + H2O
thiocholine + isobutyrate
recombinant enzyme shows about 15% activity compared to acetylthiocholine
-
?
methylthiocholine + H2O

thiocholine + methanol
-
-
-
?
methylthiocholine + H2O
thiocholine + methanol
-
-
-
?
N-2-acetoxyethyl-N-methylpiperidinium + H2O

?
-
-
-
?
N-2-acetoxyethyl-N-methylpiperidinium + H2O
?
-
-
-
?
neuropeptides + H2O

?
-
degradation
-
?
neuropeptides + H2O
?
-
degradation
-
?
neuropeptides + H2O
?
-
degradation
-
?
neuropeptides + H2O
?
-
degradation
-
?
paraoxon + H2O

diethylphosphate + 4-nitrophenol
-
mutant G122H/Y124Q/S125T, no activity with the wild-type enzyme
-
?
paraoxon + H2O
diethylphosphate + 4-nitrophenol
-
mutant G117H, no activity with the wild-type enzyme
-
?
pentanoylthiocholine + H2O

thiocholine + pentanoate
-
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
pentanoylthiocholine + H2O
thiocholine + pentanoate
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
phenylacetylthiocholine + H2O

thiocholine + phenylacetate
-
recombinant enzyme shows about 7% activity compared to acetylthiocholine
-
?
phenylacetylthiocholine + H2O
thiocholine + phenylacetate
recombinant enzyme shows about 3% activity compared to acetylthiocholine
-
?
pivaloylthiocholine + H2O

thiocholine + pivalate
-
recombinant enzyme shows about 5% activity compared to acetylthiocholine
-
?
pivaloylthiocholine + H2O
thiocholine + pivalate
recombinant enzyme shows less than 1% activity compared to acetylthiocholine
-
?
propionylthiocholine + H2O

propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
preferred over acetylthiocholine
-
?
propionylthiocholine + H2O

thiocholine + propionate
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
71% and 64% activity compared to acetylthiocholine with isozymes AChEA and AChEB, respectively
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
recombinant enzyme shows about 52% activity compared to acetylthiocholine
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
native and recombinant enzyme show about 70% activity compared to acetylthiocholine
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
good substrate
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
low activity
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
-
-
?
propionylthiocholine iodide + H2O

thiocholine iodide + propionate
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
-
preferred substrate
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
-
74.6% activity compared to acetylthiocholine
-
?
propionylthiocholine iodide + H2O
thiocholine iodide + propionate
-
-
-
?
propylthiocholine + H2O

thiocholine + propanol
-
-
-
?
propylthiocholine + H2O
thiocholine + propanol
-
-
-
?
S-acetylthiocholine + H2O

acetate + thiocholine
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine + H2O
acetate + thiocholine
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O

acetate + thiocholine iodide
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB, the enzyme contains a Ser, Glu, and His catalytic triad, overview
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-acetylthiocholine iodide + H2O
acetate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
?
S-butyrylthiocholine + H2O

thiocholine + butyrate
-
-
-
?
S-butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
?
additional information

?
-
-
AChE1 is also activity with propionylthiocholine iodide and butyrylthiocholine iodide
-
?
additional information
?
-
-
acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: beta-endorphin, angiotensin, oxytoxin, vasopressin
-
?
additional information
?
-
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview
-
?
additional information
?
-
Checx1, Checx2, and Checx3 are three carboxylesterases, that perform the acetylcholineesterase reaction, overview
-
?
additional information
?
-
Checx1, Checx2, and Checx3 are three carboxylesterases, that perform the acetylcholineesterase reaction, overview
-
?
additional information
?
-
Checx1, Checx2, and Checx3 are three carboxylesterases, that perform the acetylcholineesterase reaction, overview
-
?
additional information
?
-
-
Checx1, Checx2, and Checx3 are three carboxylesterases, that perform the acetylcholineesterase reaction, overview
-
?
additional information
?
-
isoform AChE1 is the dominant activity in Ctenocephalides felis imagoes
-
?
additional information
?
-
isoform AChE1 is the dominant activity in Ctenocephalides felis imagoes
-
?
additional information
?
-
-
isoform AChE1 is the dominant activity in Ctenocephalides felis imagoes
-
?
additional information
?
-
active site structure and substrate channels of wild-type and mutant enzymes, overview
-
?
additional information
?
-
-
active site structure and substrate channels of wild-type and mutant enzymes, overview
-
?
additional information
?
-
-
the Dugesia japonica nezyme DjChE has intermediate features of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE, EC 3.1.1.8). Two candidate genes, Djche1 and Djche2, are responsible for DjChE activity
-
?
additional information
?
-
-
complex with fasciculin-2 exhibits hydrolytic activity in a buryrylcholinesterase-like kinetics, the switch appears to be a consequence of steric obstruction, but also the consequence of subtle rapid conformational changes around the catalytic site
-
?
additional information
?
-
-
development of an assay method for quantification of the product of enzymatic reaction using substrate as internal standard, thus eliminating the need for addition of an internal standard, mass spectrometric analysis, overview
-
?
additional information
?
-
-
activity detection using a capillary electrophoresis, EMMA, method, screening method development and optimization of experimental conditions, overview
-
?
additional information
?
-
thiols block the enzymatic etching of gold nanorods(thiocholine on the rate of horseradish peroxidase-catalyzed AuNR etching), application to colorimetric detection of acetylcholinesterase activity and its inhibitors, overview
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
lethal effects due to enzyme inhibition in vivo appear at inhibition levels over 50%
-
?
additional information
?
-
-
all substrate are used as iodides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
-
calcium-activated BuchE, EC 3.1.1.8, acts as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue, overview
-
?
additional information
?
-
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview
-
?
additional information
?
-
-
acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission
-
?
additional information
?
-
-
inhibition of AChE, along with the butyrylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
?
additional information
?
-
-
bioassay for inhibition of fibril formation, i.e. Thioflavin T assay
-
?
additional information
?
-
-
the ensemble of compound 1 and compound 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview
-
?
additional information
?
-
interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators, analysis of reactivation and inhibition kinetics in vitro, overview
-
?
additional information
?
-
-
interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators, analysis of reactivation and inhibition kinetics in vitro, overview
-
?
additional information
?
-
no activity with butyrylcholine
-
?
additional information
?
-
-
nonspecific inhibitor neostigmine is used to inhibit hemolysate AChE activity in order to understand the specificity of AChE for 1-naphthyl acetate or acetylthiocholine, substrate docking with AChE, BChE (EC 3.1.1.8), albumin and esterase D, acetylcholine docks with AChE, BChE, albumin and esterase D, overview
-
?
additional information
?
-
substrate specificities of AChE compared to butyrylcholinesterase (EC 3.1.1.8) and cocaine esterase (EC 3.1.1.84)
-
?
additional information
?
-
the acetylcholinesterase (AChE) enzyme activity is detected using the 5,5'-dithio-bis(2-nitrobenzoic acid)-based colorimetric assay with measurement of the absorbance at 412 nm. 2,6-Dichloroindophenol acetate is performed as a chromogenic substrate also suitable for AChE activity examination
-
?
additional information
?
-
-
the acetylcholinesterase (AChE) enzyme activity is detected using the 5,5'-dithio-bis(2-nitrobenzoic acid)-based colorimetric assay with measurement of the absorbance at 412 nm. 2,6-Dichloroindophenol acetate is performed as a chromogenic substrate also suitable for AChE activity examination
-
?
additional information
?
-
-
activity detection with chromogenic reagent 5,5'-dithiobis-(2-nitrobenzoic) acid (DTNB)
-
?
additional information
?
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
-
pivotal role in the cholinergic system, rapid termination of nerve impulse transmission
-
?
additional information
?
-
-
the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
-
?
additional information
?
-
substrate and product trafficking through the active center gorge of the enzyme analyzed by crystallography and equilibrium binding, binding structures, overview
-
?
additional information
?
-
-
substrate and product trafficking through the active center gorge of the enzyme analyzed by crystallography and equilibrium binding, binding structures, overview
-
?
additional information
?
-
-
brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway, overview
-
?
additional information
?
-
-
presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview
-
?
additional information
?
-
-
Mytilus galloprovincialis ChE degrades preferentially acetylthiocholine (AcSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and propionylthiocholine (PrSCh), while butyrylthiocholine (BuSCh) is poorly hydrolysed. About 9% to 10% of the ChE activity observed, with AcSCh as substrate, is probably due to other esterases (CoEs) activity
-
?
additional information
?
-
-
Perforatus perforatus ChE degrades preferentially acetylthiocholine (AcSCh), and acetyl-beta-methylthiocholine (AbSCh), followed by propionylthiocholine (PrSCh), and shows only low activity with butyrylthiocholine (BuSCh)
-
?
additional information
?
-
-
Pollicipes pollicipes ChE degrades preferentially propionylthiocholine (PrSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and acetylthiocholine (AcSCh), while butyrylthiocholine (BuSCh) is not hydrolysed
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
AChE is an acetylcholine-hydrolyzing enzyme and is implicated in cognitive functions and probably plays important roles in neurodegenerative disorders, including Alzheimer's disease
-
?
additional information
?
-
-
acts on a variety of acetic acid esters, also catalyzes transacetylation
-
?
additional information
?
-
-
no activity with butyrylthiocholine
-
?
additional information
?
-
the catalytic triad is formed by His440, Glu327, and Ser200, Trp84 and Trp279 are important for the enzyme activity
-
?
additional information
?
-
-
acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
no substrate: S-butyrylthiocholine
-
?
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