Activating Compound | Comment | Organism | Structure |
---|---|---|---|
presenilin 1 | PS1, required for enzyme activity in the brain, overview. PS1-deficient mice show upregulation of AChE activity in major cholinergic cell nuclei and in cortical and thalamic regions responsible for selective attention and visuomotor coordination, as well as limbic structures with related regions involved in cognition, arousal, emotion, and plasticit, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | - |
Mus musculus | - |
brain | medial septum, vertical diagonal band,substantia inominata, eye field, posterior parietal and visual cortices, posterior thalamic and lateral geniculate nuclei, hippocampal formation and amygdala, midline, periventricular, reticular thalamic nuclei, and lateral prefrontal, agranular insular cortices | Mus musculus | - |
cerebral cortex | - |
Mus musculus | - |
corpus striatum | - |
Mus musculus | - |
forebrain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
additional information | brain tissue localization of AChE, overview | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme activity in wild-type and PS1/A246E transgenic mice, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | presenilin 1, PS1, is required for enzyme activity in the brain, PS1/A246E transgenic mice have altered AChE activity in several regions also vulnerable in Alzheimer pathology, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Mus musculus |