Literature summary for 3.1.1.64 extracted from

Redmond, T.M.; Yu, S.; Lee, E.; Bok, D.; Hamasaki, D.; Chen, N.; Goletz, P.; Ma, J.X.; Crouch, R.K.; Pfeifer, K.
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle (1998), Nat. Genet., 20, 344-351.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
retinal pigment epithelium	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
all-trans-retinyl ester + H2O	-	Mus musculus	11-cis-retinol + a fatty acid	-	?

Synonyms

Synonyms	Comment	Organism
Rpe65	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	outer segment discs of rod photoreceptors in Rpe65-deficient mice are disorganized, rod function is abolished although cone function remains. Rpe65-deficient mice lack rhodopsin, but not opsin apoprotein	Mus musculus
physiological function	Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle	Mus musculus

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Release 2023.1 (January 2023)