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Literature summary for 2.7.7.48 extracted from

  • Ju, J.; Li, X.; Kumar, S.; Jockusch, S.; Chien, M.; Tao, C.; Morozova, I.; Kalachikov, S.; Kirchdoerfer, R.N.; Russo, J.J.
    Nucleotide analogues as inhibitors of SARS-CoV polymerase (2020), Pharmacol. Res. Perspect., 8, e00674 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
3'-azido-3'-deoxythymidine triphosphate incorporated by SARS-CoV RNA-dependent RNA polymerase (RdRp), and blocks further incorporation by the polymerase Severe acute respiratory syndrome coronavirus 2
3'-fluoro-3'-deoxythymidine triphosphate incorporated by SARS-CoV RNA-dependent RNA polymerase (RdRp), and blocks further incorporation by the polymerase Severe acute respiratory syndrome coronavirus 2
sofosbuvir triphosphate sofosbuvir triphosphate is incorporated by SARS-CoV RNA-dependent RNA polymerase (RdRp), and blocks further incorporation by the polymerase. Sofosbuvir triphosphate is not incorporated by a host-like high-fidelity DNA polymerase Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?