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Literature summary for 2.7.12.2 extracted from

  • Tang, Z.; Cao, X.; Zhang, Y.; Jiang, J.; Qiao, D.; Xu, H.; Cao, Y.
    Two splice variants of the DsMEK1 mitogen-activated protein kinase kinase (MAPKK) are involved in salt stress regulation in Dunaliella salina in different ways (2020), Biotechnol. Biofuels, 13, 147 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm both splice variants MEK1-X1 and MEK1-X2 Dunaliella salina 5737
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Organism

Organism UniProt Comment Textmining
Dunaliella salina
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-
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Synonyms

Synonyms Comment Organism
MEK1
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 Dunaliella salina

Expression

Organism Comment Expression
Dunaliella salina expression of splice variant MEK1-X2 is induced by salt stress up

General Information

General Information Comment Organism
physiological function alternative splicing of MEK1 leads to variants MEK1-X1 and MEK1-X2 both localized in the cytoplasm. MEK1-X2 is induced by salt stress. Overexpression of MEK1-X2 leads to a higher increase rate of glycerol production compared to the control and MEK1-X1 overexpression under salt stress. Under salt stress, the expression of GPDH2/3/5/6 increases in MEK1-X2 overexpression strains compared to the control. Overexpression of MEK1-X1 increases the proline content and reduces the malondialdehyde content under salt stress, and MEK1-X1 is able to regulate oxidative stress. MEK1-X2 can interact with MAPKKK1/2/3/9/10/17 and MAPK1. MEK1-X1 interacts with neither upstream MAPKKK nor downstream MAPK. MEK1-X2 overexpressing transgenic lines increase the expression of MAPKKK1/3/10/17 and MAPK1, and MEK1-X2 RNAi lines decrease the expression of MAPKKK2/10/17 Dunaliella salina