Application | Comment | Organism |
---|---|---|
drug development | design and synthesis of a new series of MEK1 inhibitors, the 4-anilino-5-carboxamido-2-pyridones | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
MEK1, to a resolution of 2.8 A | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2,3-dihydroxypropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
1-(3-cyanopropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
1-allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
1-ethyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
1-methyl-4-(2-naphthylamino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-1-(2-hydroxyethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-1-(3-hydroxypropyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-6-oxo-1-propyl-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-N,1-dimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-N,N,1-trimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-iodoanilino)-N-(3-hydroxypropyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-methylanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(2-fluoro-4-methylsulfanylphenylamino)-1-methyl-6-oxo-1,6-dihydro-3 -pyridinecarboxamide | - |
Mus musculus | |
4-(3,4-dichlorophenylamino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(4-bromo-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(4-bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(4-cyano-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(4-ethyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-(4-ethynyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-amino-1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-2-hydroxybutan-1-one | - |
Mus musculus | |
4-[2-fluoro-4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)anilino]-1-methyl-6-oxo-1,6 -dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-[2-fluoro-4-(3-hydroxypropyl)anilino]-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | - |
Mus musculus | |
4-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-3-hydroxy-4-oxobutanamide | - |
Mus musculus | |
CI-1040 | - |
Mus musculus | |
ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate | - |
Mus musculus | |
additional information | design and synthesis of 4-anilino-5-carboxamido-2-pyridone MEK1 inhibitors using a combination of medicinal chemistry, computational chemistry, and structural elucidation, overview. Binding structure analysis, overview | Mus musculus | |
PD318088 | - |
Mus musculus | |
PD334581 | - |
Mus musculus | |
tert-butyl [5-(aminocarbonyl)-4-(2-fluoro-4-iodoanilino)-2-oxo-1(2H)-pyridinyl]acetate | - |
Mus musculus | |
[5-(aminocarbonyl)-4-(2-fluoro-4-iodoanilino)-2-oxo-1(2H)-pyridinyl]acetic acid | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | P31938 | MEK1 | - |
Mus musculus | Q63932 | MEK2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Colon-26 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
MEK1 | - |
Mus musculus |
MEK2 | - |
Mus musculus |
mitogen-activated protein kinase kinase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000012 | - |
cascade IC50 | Mus musculus | 4-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-3-hydroxy-4-oxobutanamide | |
0.000004 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000005 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000016 | - |
clinical candidate, inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | CI-1040 | |
0.0000174 | - |
cascade IC50 | Mus musculus | 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide | |
0.000018 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000018 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000021 | - |
colon26 cellular assay | Mus musculus | 4-(4-ethynyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000023 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000023 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000046 | - |
clinical candidate, colon26 cellular assay | Mus musculus | CI-1040 | |
0.000061 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(3-hydroxypropyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000061 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(3-hydroxypropyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000063 | - |
colon26 cellular assay | Mus musculus | ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate | |
0.0000842 | - |
cascade IC50 | Mus musculus | 4-amino-1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-2-hydroxybutan-1-one | |
0.000091 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 1-allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000093 | - |
colon26 cellular assay | Mus musculus | 4-(4-bromo-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000095 | - |
colon26 cellular assayy | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(3-hydroxypropyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0001 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0001 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(4-ethynyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0001 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0001 | - |
cascade IC50 | Mus musculus | 4-(4-ethynyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00011 | - |
colon26 cellular assay | Mus musculus | 4-(4-ethyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00012 | - |
colon26 cellular assay | Mus musculus | 4-(4-bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00015 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-methylsulfanylphenylamino)-1-methyl-6-oxo-1,6-dihydro-3 -pyridinecarboxamide | |
0.00018 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000195 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N,1-dimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000195 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N,1-dimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000206 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00021 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000356 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-methylsulfanylphenylamino)-1-methyl-6-oxo-1,6-dihydro-3 -pyridinecarboxamide | |
0.00036 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-methylsulfanylphenylamino)-1-methyl-6-oxo-1,6-dihydro-3 -pyridinecarboxamide | |
0.000425 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid | |
0.000425 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid | |
0.00043 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-6-oxo-1-propyl-1,6-dihydro-3-pyridinecarboxamide | |
0.000627 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N,N,1-trimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00063 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.000669 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate | |
0.00067 | - |
cascade IC50 | Mus musculus | ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate | |
0.001 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 1-ethyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.001 | - |
cascade IC50 | Mus musculus | 1-ethyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00113 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00113 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0019 | - |
cascade IC50 | Mus musculus | 4-(4-bromo-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00191 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(4-bromo-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00254 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-6-oxo-1-propyl-1,6-dihydro-3-pyridinecarboxamide | |
0.00254 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-(2-hydroxyethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00254 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-6-oxo-1-propyl-1,6-dihydro-3-pyridinecarboxamide | |
0.00262 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(4-ethyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00262 | - |
cascade IC50 | Mus musculus | 4-(4-ethyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00297 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-methylanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00297 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-methylanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.003 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-(3-hydroxypropyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.003 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 1-methyl-4-(2-naphthylamino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.003 | - |
above, cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-(3-hydroxypropyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.003 | - |
cascade IC50 | Mus musculus | 1-methyl-4-(2-naphthylamino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00363 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(4-bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00363 | - |
cascade IC50 | Mus musculus | 4-(4-bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0039 | - |
colon26 cellular assay | Mus musculus | 4-(3,4-dichlorophenylamino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00489 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 1-(3-cyanopropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0049 | - |
cascade IC50 | Mus musculus | 1-(3-cyanopropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.005 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid | |
0.005 | - |
colon26 cellular assay | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-(2-hydroxyethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.005 | - |
above cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-1-(2-hydroxyethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.0057 | - |
cascade IC50 | Mus musculus | 4-(3,4-dichlorophenylamino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00572 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(3,4-dichlorophenylamino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.00601 | - |
cascade IC50 | Mus musculus | 1-allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.01 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 1-allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.01 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-[2-fluoro-4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)anilino]-1-methyl-6-oxo-1,6 -dihydro-3-pyridinecarboxamide | |
0.01 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-(4-cyano-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.01 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | 4-[2-fluoro-4-(3-hydroxypropyl)anilino]-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.01 | - |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay | Mus musculus | tert-butyl [5-(aminocarbonyl)-4-(2-fluoro-4-iodoanilino)-2-oxo-1(2H)-pyridinyl]acetate | |
0.01 | - |
above, cascade IC50 | Mus musculus | 4-[2-fluoro-4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)anilino]-1-methyl-6-oxo-1,6 -dihydro-3-pyridinecarboxamide | |
0.01 | - |
above, cascade IC50 | Mus musculus | 4-(4-cyano-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.01 | - |
above, cascade IC50 | Mus musculus | 4-[2-fluoro-4-(3-hydroxypropyl)anilino]-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
0.01 | - |
above, cascade IC50 | Mus musculus | [5-(aminocarbonyl)-4-(2-fluoro-4-iodoanilino)-2-oxo-1(2H)-pyridinyl]acetic acid | |
0.01 | - |
above, cascade IC50 | Mus musculus | 1-(2,3-dihydroxypropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | |
1.2 | - |
cascade IC50 | Mus musculus | 4-(2-fluoro-4-iodoanilino)-N,N,1-trimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide |