BRENDA - Enzyme Database show
show all sequences of 2.7.11.30

Down-regulation of transforming growth factor beta 1/activin receptor-like kinase 1 pathway gene expression by herbal compound 861 is related to deactivation of LX-2 cells

Li, L.; Zhao, X.Y.; Wang, B.E.; World J. Gastroenterol. 14, 2894-2899 (2008)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
LX-2 cell
-
Homo sapiens
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
LX-2 cell
-
Homo sapiens
-
Expression
Organism
Commentary
Expression
Homo sapiens
down-regulation of ALK1 in LX-2 cells by the herbal compound Cpd861, cells are treated with TGF-beta1 (5 ng/ml) Cpd861 (0.1 mg/ml), TGF-beta1 (5 ng/ml) plus Cpd861 (an extract of 10 herbs traditionally applied as chinese medicine, 5 ng/ml) for 24 h to investigate the effect of Cpd861 on the TGF-beta1/ALK1 pathway
down
Homo sapiens
the ALK1 gene is constitutively expressed in LX-2 cells and TGF-beta1 does not further increase its expression
additional information
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
down-regulation of ALK1 in LX-2 cells by the herbal compound Cpd861, cells are treated with TGF-beta1 (5 ng/ml) Cpd861 (0.1 mg/ml), TGF-beta1 (5 ng/ml) plus Cpd861 (an extract of 10 herbs traditionally applied as chinese medicine, 5 ng/ml) for 24 h to investigate the effect of Cpd861 on the TGF-beta1/ALK1 pathway
down
Homo sapiens
the ALK1 gene is constitutively expressed in LX-2 cells and TGF-beta1 does not further increase its expression
additional information
Other publictions for EC 2.7.11.30
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Insulin gene is a target in ac ...
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Inhibition of the TGF-beta rec ...
Homo sapiens
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4
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2
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Homo sapiens
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6
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Homo sapiens
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5
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Bueno
Semi-mechanistic modelling of ...
Homo sapiens
Eur. J. Cancer
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6
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1
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6
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1
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Smad4-dependent TGF-beta signa ...
Homo sapiens
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283
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7
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3
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1
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7
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3
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693381
Young
The activin receptor-like kina ...
Ovis aries
J. Endocrinol.
196
251-261
2008
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1
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694090
Xu
Cyclin G2 is degraded through ...
Homo sapiens
Mol. Biol. Cell
19
4968-4979
2008
-
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2
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1
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4
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4
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706906
Li
Down-regulation of transformin ...
Homo sapiens
World J. Gastroenterol.
14
2894-2899
2008
-
-
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-
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1
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2
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2
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664721
Zhang
Activin receptor-like kinase 7 ...
Rattus norvegicus
Diabetologia
49
506-518
2006
3
-
1
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1
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3
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2
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5
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1
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1
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5
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4
1
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664088
Peng
Kinetic characterization of no ...
Homo sapiens
Biochemistry
44
2293-2304
2005
-
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1
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1
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4
4
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1
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2
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1
1
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9
1
1
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1
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1
3
-
4
-
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1
1
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1
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4
4
3
4
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1
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1
1
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9
1
1
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1
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664715
Desgrosellier
Activin receptor-like kinase 2 ...
Gallus gallus
Dev. Biol.
280
201-210
2005
1
-
1
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1
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1
-
1
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3
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665640
Ungefroren
Transforming growth factor-bet ...
Homo sapiens
J. Biol. Chem.
280
2644-2652
2005
1
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665699
Lux
Human retroviral gag- and gag- ...
Homo sapiens
J. Biol. Chem.
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2005
1
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1
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1
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666443
Halder
A specific inhibitor of TGF-be ...
Homo sapiens
Neoplasia
7
509-521
2005
1
-
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1
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1
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2
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663984
Ge
Selective inhibitors of type I ...
Homo sapiens
Biochem. Pharmacol.
68
41-50
2004
2
-
1
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1
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1
1
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2
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3
-
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3
-
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3
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1
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1
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1
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2
-
1
1
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1
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1
1
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2
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-
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3
-
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3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664036
Ottesen
Semisynthesis of phosphovarian ...
Homo sapiens
Biochemistry
43
5698-5706
2004
2
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1
2
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2
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2
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4
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1
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1
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1
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2
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4
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1
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1
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664318
Sawyer
Synthesis and activity of new ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
14
3581-3584
2004
2
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1
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6
-
2
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2
-
2
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1
-
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2
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2
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2
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2
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2
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6
2
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1
2
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6
6
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2
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2
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1
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2
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665532
Kim
Activin receptor-like kinase-7 ...
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3
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3
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Yakymovych
Smad2 phosphorylation by type ...
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2
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5
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1
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1
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666283
Forrester
Tegumental expression of a nov ...
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2004
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1
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4
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4
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666359
Mazerbourg
Growth differentiation factor- ...
Rattus norvegicus
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2
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1
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1
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4
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664282
Roberts
Identification of novel isofor ...
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2003
2
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1
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1
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1
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2
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8
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8
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665481
Liu
Smads 2 and 3 are differential ...
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1
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Harrison
Identification of a functional ...
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2
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1
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27
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1
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1
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1
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1
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1
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27
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1
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666312
Goumans
Activin receptor-like kinase ( ...
Mus musculus
Mol. Cell
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817-828
2003
2
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1
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1
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1
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1
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1
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5
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666512
Fink
TGF-beta-induced nuclear local ...
Homo sapiens
Oncogene
22
1317-1323
2003
1
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