Any feedback?
Literature summary for 2.7.11.30 extracted from
- Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta (2005), J. Biol. Chem., 280, 2644-2652.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TGF-beta | activates the TGF-beta type I receptor kinase by binding, affects BGN and GADDbeta45 expression in PANC-1 and M-63 cells via ALK5 and Smad phosphorylation/activation, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad | Homo sapiens | involved in ALK5 activation of p38 MAPK signaling and of GADDbeta45 and BGN expression induced by TGF-beta | ADP + phosphorylated Smad | - |
? |  |
| additional information | Homo sapiens | the TGF-beta type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta, th TGF-beta type II receptor is required for for TGF-beta binding and signaling induction activity, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MG-63 cell | osteosarcoma cell line | Homo sapiens | - |
| osteosarcoma cell | - |
Homo sapiens | - |
| PANC-1 cell | pancreatic cancer cell line | Homo sapiens | - |
| pancreatic cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad | - |
Homo sapiens | ADP + phosphorylated Smad | - |
? | |
| ATP + Smad | involved in ALK5 activation of p38 MAPK signaling and of GADDbeta45 and BGN expression induced by TGF-beta | Homo sapiens | ADP + phosphorylated Smad | - |
? | |
| additional information | the TGF-beta type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta, th TGF-beta type II receptor is required for for TGF-beta binding and signaling induction activity, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALK5 | - |
Homo sapiens |
| TGF-beta type I receptor | - |
Homo sapiens |
| transforming growth factor-beta type I receptor | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
