Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.23 extracted from

  • Medlin, J.E.; Uguen, P.; Taylor, A.; Bentley, D.L.; Murphy, S.
    The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA (2003), EMBO J., 22, 925-934.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Inhibitors

Inhibitors Comment Organism Structure
1-(5-isoquinolinesulfonyl)-2-methylpiperazine i.e. H7, CTD kinase inhibitor Homo sapiens
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits the CTD kinase Homo sapiens
8-(methylthio)-4,5-dihydrothieno[3',4':5,6]benzoisoxazole-6-carboamide KM05283, CTD kinase inhibitor Homo sapiens
additional information no inhibition by cycloheximide, inhibition of the CTD kinase in vivo affects the 3' processing of snRNA, but only slightly the initiation and elongation of transcription of U2 genes, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [DNA-directed RNA polymerase] Homo sapiens hyperphosphorylation of the C-terminal domain CTD of the RNA polymerase II large subunit is required for transcription and 3' processing of snRNA, e.g. U1 and U2, recognition of the 3' box by the phosphorylated CTD, CTD kinase activity is not required for beta-actin expression, overview ADP + phospho-[DNA-directed RNA polymerase]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [DNA-directed RNA polymerase] hyperphosphorylation of the C-terminal domain CTD of the RNA polymerase II large subunit is required for transcription and 3' processing of snRNA, e.g. U1 and U2, recognition of the 3' box by the phosphorylated CTD, CTD kinase activity is not required for beta-actin expression, overview Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
ATP + [DNA-directed RNA polymerase] hyperphosphorylation of the C-terminal domain CTD of the RNA polymerase II large subunit Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
 ?

Synonyms

Synonyms Comment Organism
CTD kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens