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Information on EC 2.7.11.23 - [RNA-polymerase]-subunit kinase

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IUBMB Comments
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
dna-pk, tfiih, p-tefb, dna-dependent protein kinase, positive transcription elongation factor b, ctd kinase, kin28, srb10, ctdk-i, tfiih kinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [DNA-directed RNA polymerase] = ADP + phospho-[DNA-directed RNA polymerase]
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