Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin B | required for CDK1 activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p27 | a CDK inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + early mitotic inhibitor 1 protein | Homo sapiens | i.e. Emi1, is phosphorylated by CDKs in mitotic but not S-phase cell extracts | ADP + early mitotic inhibitor 1 phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa-S3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + early mitotic inhibitor 1 protein | - |
Homo sapiens | ADP + early mitotic inhibitor 1 phosphoprotein | - |
? | |
ATP + early mitotic inhibitor 1 protein | i.e. Emi1, is phosphorylated by CDKs in mitotic but not S-phase cell extracts | Homo sapiens | ADP + early mitotic inhibitor 1 phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK | - |
Homo sapiens |
Cdk1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | 7.6 | assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | cell cycle regulation is characterized by alternating activities of cyclin-dependent kinases and of the ubiquitin ligase anaphase promoting complex/cyclosome, overview. The latter is inhibited during S-phase by early mitotic inhibitor 1, which is negatively regulated by phosphorylation through CDKs, allowing the accumulation of cyclins A and B and to prevent re-replication, overview | Homo sapiens |
physiological function | CDK-mediated phosphorylation of early mitotic inhibitor 1 prevents its binding to ubiquitin ligase anaphase promoting complex/cyclosome | Homo sapiens |