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Information on EC 2.7.11.22 - cyclin-dependent kinase

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IUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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ATP
+
a protein
=
ADP
+
a phosphoprotein
+
=
+
Synonyms
cyclin-dependent kinase, cdk, p34cdc2, cdc2 kinase, cyclin-dependent kinase 5, cyclin-dependent kinase 2, cdc28, cyclin-dependent kinase 4, cyclin-dependent kinase 1, cdc42p, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
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