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Information on EC 2.7.11.22 - cyclin-dependent kinase
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2.7.11.22 cyclin-dependent kinaseIUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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Word Map
- 2.7.11.22
-
p27kip1
- retinoblastoma
-
mitosis
-
cell-cycle
-
checkpoint
- histone
-
s-phase
- tumorigenesis
-
p16ink4a
-
antiproliferative
-
hyperphosphorylation
- chromatin
- prostate
- proteasome
- spindle
- carcinogenesis
- melanoma
- oocyte
- lymphoma
- xenopus
-
quiescent
- microtubule
-
fission
- caspase-3
- alzheimer
- myeloid
-
signal-regulated
-
p21waf1
-
interphase
-
metaphase
-
cytokinesis
-
cycle-dependent
-
oncoproteins
-
anaphase
-
tgf-beta
- parp
-
p53-independent
- pombe
-
postmitotic
- centrosome
-
polo-like
-
cdc25c
- papillomavirus
-
ubiquitin-mediated
-
growth-inhibitory
-
p53-mediated
-
aurora
-
survivin
-
prophase
-
bcl-xl
- medicine
- drug development
- analysis
- pharmacology
The enzyme appears in viruses and cellular organisms
Synonyms
cdk, p34cdc2, cdc2 kinase, cyclin-dependent kinase 5, cdc28, cyclin-dependent kinase 2, cyclin-dependent kinase 4, cyclin-dependent kinase 1, cdc42p, pho85, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A-type cyclin-dependent kinase A
B-type cyclin-dependent kinase
Cdc2
CDC2 kinase
cdc2-related kinase 12
Cdc28
cdc28p
CDC2deltaT
a variant of human CDC2, that lacks 171 nucleotides corresponding to 57 amino acids, which compose most of the T-loop
CDK
Cdk1
CDK2
CDK3
CDK4
CDK4 kinase
Cdk5
cdk6
cdk7
CDK9
CDKA
CDKA;1
CDKB
CDKC2
cell division control protein 2
cell division control protein 2 homolog
cell division control protein 2 homolog 1
cell division control protein 2 homolog 2
cell division control protein 2 homolog A
cell division control protein 28
cell division protein kinase 2
cell division protein kinase 2 homolog
cell division protein kinase 4
cell division protein kinase 5
cell division protein kinase 7
CRK12:CYC9
cyclin A2/Cdk2
cyclin dependent kinase 2
cyclin-dependent kinase
cyclin-dependent kinase 1
cyclin-dependent kinase 2
cyclin-dependent kinase 4
cyclin-dependent kinase 5
cyclin-dependent kinase 7
cyclin-dependent kinase 9
cyclin-dependent kinase A
Cyclin-dependent kinase pef1
-
-
-
-
cyclin-dependent kinase-2
cyclin-dependent kinase-5
cyclin-dependent protein kinase 5
G1/S cyclin-dependent kinase
galactosyltransferase associated protein kinase p58/GTA
male germ cell-associated kinase
negative regulator of the PHO system
-
p34cdc2 protein kinase
p40MO15
PHO85
PHO85 homolog
-
-
-
-
phosphate-activated cyclin-dependent kinase
phosphate-sensing CDK
serine/threonine-protein kinase KIN28
-
serine/threonine-protein kinase MAK
serine/threonine-protein kinase PCTAIRE-1
serine/threonine-protein kinase PCTAIRE-2
serine/threonine-protein kinase PCTAIRE-3
UL97 protein
-
has activities similar to cellular cyclin-cyclin-dependent kinase complexes
additional information
CDK
-
-
Cdk1
-
-
CDK2
-
-
CDK4
-
-
Cdk5
-
-
Cdk5
-
-
Cdk5
-
-
CDK9
CDK9 is a cdc2-like Ser/Thr kinase whose complexes with T- and K-type cyclins constitute the basal transcription factor P-TEFb
CDKC2
combines the functions of both CRK7 and CDK9, and can also couple splicing with transcription
cell division control protein 2
-
cell division control protein 2 homolog A
-
cell division protein kinase 2
-
cell division protein kinase 2 homolog
-
cell division protein kinase 7
-
cyclin-dependent kinase 2
-
-
cyclin-dependent kinase 5
-
-
cyclin-dependent kinase 5
-
-
cyclin-dependent kinase 5
-
-
cyclin-dependent kinase 7
as part of the CDK-activating kinase complex, CDK7 is a component of the basal transcription factor TFIIH
cyclin-dependent kinase 7
as part of the CDK-activating kinase complex, CDK7 is a component of the basal transcription factor TFIIH
cyclin-dependent kinase 9
part of the positive transcription elongation factor b
additional information
-
CDK5 is a unique member of the CDK family, see also EC 2.7.11.26; the enzyme belongs to the CDK family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
-
-
-
-
ATP + a protein = ADP + a phosphoprotein
activation involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated at a Thr residue, phosphorylation leads to enzyme inhibition
-
ATP + a protein = ADP + a phosphoprotein
active site amino acid sequences of PK5 and mrk
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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CAS REGISTRY NUMBER
COMMENTARY
150428-23-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acidic alpha-syntrophin protein
ADP + acidic alpha-syntrophin phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + ADAQHATPPKKKRKVEDPKDF
ADP + ADAQHAT(P)PPKKKRKVEDPKDF
-
a histone peptide substrate
-
-
?
ATP + ADP-ribosylation factor GTPase activating protein 3 protein
ADP + ADP-ribosylation factor GTPase activating protein 3 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + AE binding protein 2 protein
ADP + AE binding protein 2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + APEX nuclease protein
ADP + APEX nuclease phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ARAF serine/threonine protein kinase protein
ADP + ARAF serine/threonine protein kinase phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ATRIP protein
ADP + ATRIP phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + B-cell lymphoma protein 2
ADP + phosphorylated B-cell lymphoma protein 2
-
B-cell lymphoma protein 2 is phosphorylated at Ser70, Cdk5-mediated B-cell lymphoma protein 2 phosphorylation is pivotal for the antiapoptotic effect of Bcl-2 and contributes to the maintenance of neuronal survival by Cdk5
-
-
?
ATP + biotin-TVSEESNVLCLSKSPNKHNRLYMKARPFF
ADP + biotin-TVSEESNVLCLSKpSPNKHNRLYMKARPFF
-
-
phosphorylated on Ser595
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
ATP + CAK
ADP + phosphorylated CAK
-
substrate of cyclin-dependent kinase cdk7
-
-
?
ATP + CALD1 protein
ADP + CALD1 phosphoprotein
-
reccombinant human GST-tagged substrate, with CDK6
-
-
?
ATP + cAMP responsive element binding protein 3-like 2 protein
ADP + cAMP responsive element binding protein 3-like 2 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + CCAAT/enhancer binding protein gamma protein
ADP + CCAAT/enhancer binding protein gamma phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
phosphorylation of Thr161
-
-
-
ATP + cdc2 PK
ADP + phosphorylated cdc2 PK
-
substrate of cyclin-dependent kinase activating kinase CAK
-
-
?
ATP + cdc2-like protein
ADP + phosphorylated cdc2-like protein from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
-
-
-
ATP + CDK1
ADP + phosphorylated CDK1
-
CDK7 phosphorylates the activation segment or T-loop of CDK1
-
-
?
ATP + coiled-coil domain protein 52 protein
ADP + coiled-coil domain protein 52 phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + collapsing response mediator protein
ADP + phosphorylated collapsing response mediator protein
-
-
-
-
?
ATP + CPEB-associated factor Maskin protein
ADP + CPEB-associated factor Maskin phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + cyclin dependent kinase 2
ADP + phosphorylated cyclin dependent kinase 2
-
cyclin activating kinase CAK phosphorylates Thr160 of cdk2, a prerequisite for cell cycle control
-
-
?
ATP + cyclin-dependent kinase
ADP + phosphorylated cyclin-dependent kinase
-
-
-
-
?
ATP + diacylglycerol kinase epsilon protein
ADP + diacylglycerol kinase epsilon phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + diphthamide biosynthesis protein 2 isoform a protein
ADP + diphthamide biosynthesis protein 2 isoform a phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + distal-less homeobox 1 isoform 1 protein
ADP + distal-less homeobox 1 isoform 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + dopamine
ADP + phosphorylated dopamine
-
phosphorylation by cdk5
-
-
?
ATP + dopamine and cAMP-regulated phosphoprotein
ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34
-
-
?
ATP + Erp1/emi2 protein
ADP + Erp1/emi2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + establishment of cohesion-1 homologue 2 protein
ADP + establishment of cohesion-1 homologue 2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + estrogen receptor
ADP + phosphorylated estrogen receptor
-
Cdk2 phosphorylation at Ser104 and Ser106
-
-
?
ATP + ETS variant gene-1 protein
ADP + ETS variant gene-1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + ezrin
ADP + phosphorylated ezrin
-
phosphorylation by cdk5 at Thr235 in the NH2-terminal region and consequent dissociation of Rho GDP dissociation inhibitor from an ezrin/Rho-GDI complex
-
-
?
ATP + Fizzy1 protein
ADP + Fizzy1 phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + glucocorticoid receptor
ADP + dephosphorylated glucocorticoid receptor
-
CDK5 phosphorylates glucocorticoid receptor at multiple serines, including Ser203 and Ser211 of its N-terminal domain, and suppresses the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to DNA
-
-
?
ATP + glycogenin protein
ADP + glycogenin phosphoprotein
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + granulin isoform 1 precursor protein
ADP + granulin isoform 1 precursor phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + heat shock transcription factor 1 protein
ADP + heat shock transcription factor 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Hermes protein
ADP + Hermes phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + high-molecular-weight neurofilament
ADP + phosphorylated high-molecular-weight neurofilament
-
-
-
-
-
ATP + histone deacetylase 6 protein
ADP + histone deacetylase 6 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + histone H1-derived peptide
ADP + histone H1-derived peptide phosphate
-
-
-
-
?
ATP + histone stem-loop binding protein
ADP + histone stem-loop binding phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + human cytomegalovirus tegument protein pp65
ADP + phosphorylated human cytomegalovirus tegument protein pp65
-
-
-
-
?
ATP + Kunitz type serine protease inhibitor 2 protein
ADP + Kunitz type serine protease inhibitor 2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + lamina-associated protein 2-beta isoform protein
ADP + lamina-associated protein 2-beta isoform phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + LOC222229 protein
ADP + LOC222229 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + low density lipoprotein receptor adaptor protein 1 protein
ADP + low density lipoprotein receptor adaptor protein 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + MAP/microtubule affinity regulating kinase 3 protein
ADP + MAP/microtubule affinity regulating kinase 3 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + maternal embryonic leucine zipper kinase protein
ADP + maternal embryonic leucine zipper kinase phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + MGC86234 protein
ADP + MGC86234 phosphoprotein
-
i.e. potassium channel tetramerisation domaincontaining 3, substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + microtubule-associated tau
ADP + phosphorylated microtubule-associated tau
-
-
-
-
-
ATP + mini-chromosomemaintenance protein 2
ADP + phosphorylated mini-chromosomemaintenance protein 2
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 3
ADP + phosphorylated mini-chromosomemaintenance protein 3
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 4
ADP + phosphorylated mini-chromosomemaintenance protein 4
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 5
ADP + phosphorylated mini-chromosomemaintenance protein 5
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 6
ADP + phosphorylated mini-chromosomemaintenance protein 6
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 7
ADP + phosphorylated mini-chromosomemaintenance protein 7
-
-
-
-
?
ATP + minor histocompatibility antigen HA-1 protein
ADP + minor histocompatibility antigen HA-1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + neurofilament heavy chain
ADP + phosphorylated neurofilament heavy chain
-
-
-
-
?
ATP + neuronal cytoskeletal protein NF-H
ADP + phosphorylated neuronal cytoskeletal protein NF-H
-
-
-
-
ATP + neuronal cytoskeletal protein tau
ADP + phosphorylated neuronal cytoskeletal protein tau
-
-
-
-
ATP + neuronal cytoskeletal proteins NF-M
ADP + phosphorylated neuronal cytoskeletal protein NF-M
-
-
-
-
ATP + origin recognition complex 1
ADP + phosphorylated origin recognition complex 1
-
-
-
-
?
ATP + origin recognition complex 2
ADP + phosphorylated origin recognition complex 2
-
-
-
-
?
ATP + origin recognition complex 3
ADP + phosphorylated origin recognition complex 3
-
-
-
-
?
ATP + origin recognition complex 4
ADP + phosphorylated origin recognition complex 4
-
-
-
-
?
ATP + origin recognition complex 5
ADP + phosphorylated origin recognition complex 5
-
-
-
-
?
ATP + origin recognition complex 6
ADP + phosphorylated origin recognition complex 6
-
-
-
-
?
ATP + p35 protein
ADP + p35 phosphoprotein
-
a nuclear transcription factor, Cdk5-p25 phosphorylates p53 on Ser15, Ser33, and Ser44
-
-
?
ATP + palmitoylated membrane protein 1 protein
ADP + palmitoylated membrane protein 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + PASCIN protein
ADP + PASCIN phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Pho81
ADP + phosphorylated Pho81
-
-
phosphorylated Pho81 is an inhibitor for Pho85
-
?
ATP + phosphatidylinositol-4-phosphate 5-kinase type IIba protein
ADP + phosphatidylinositol-4-phosphate 5-kinase type IIba phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + PIF1 protein
ADP + PIF1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + polymerase II C-terminal domain
ADP + phosphorylated polymerase II C-terminal domain
Q140014
-
-
-
?
ATP + POM21 protein
ADP + POM21 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + pre-B-cell leukemia transcription factor 1 protein
ADP + pre-B-cell leukemia transcription factor 1 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin B/CDK1
-
-
?
ATP + pre-synaptic P/Q-type voltage-dependent calcium channel
ADP + phosphorylated pre-synaptic P/Q-type voltage-dependent calcium channel
-
-
-
-
?
ATP + promyelocytic leukemia zinc finger
ADP + phosphorylated promyelocytic leukemia zinc finger
-
can also be phosphorylated by CDK1 albeit in a less efficient fashion than by CDK2
-
-
?
ATP + Rb peptide
ADP + Rb phosphopeptide
-
from retinoblastoma-associated protein
-
-
?
ATP + RNA polymerase 1 protein
ADP + RNA polymerase 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphorylated RNA polymerase II C-terminal domain
ATP + RNA polymerase II C-terminal domain protein
ADP + RNA polymerase II C-terminal domain phosphoprotein
-
-
-
-
?
ATP + RNA polymerase II carboxy-terminal domain
ADP + phosphorylated RNA polymerase II carboxy-terminal domain
-
CDK8
-
-
?
ATP + RNA polymerase II largest subunit
ADP + phosphorylated RNA polymerase II largest subunit
specifically hyperphosphorylates the carboxyl-terminal
-
-
-
ATP + RXL motif-containing peptide
ADP + RXL motif-containing phosphopeptide
-
peptide sequence corresponding to amino acids 866-880 of RNA polymerase II C-terminal domain. Substrate phosphorylation by CDK6 with K-cyclin from Kaposi sarcoma herpesvirus, but addition of this peptide significantly reduces substrate phosphorylation by cyclin E-CDK2 and cyclin D2-CDK6
-
-
?
ATP + SEC14-like 1 isoform a protein
ADP + SEC14-like 1 isoform a phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + semaphorin 6D protein
ADP + semaphorin 6D phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + Sept5 protein
ADP + phosphorylated Sept5 protein
-
Sept5 protein is phosphorylated at Ser17
-
-
?
ATP + similar to bicaudal C homologue 1 protein
ADP + similar to bicaudal C homologue 1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + similar to peroxisomal biogenesis factor 5 protein
ADP + similar to peroxisomal biogenesis factor 5 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Trigger of mitotic entry 1 protein
ADP + similar to Trigger of mitotic entry 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Zinc finger protein 516 protein
ADP + similar to Zinc finger protein 516 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 protein
ADP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + SmcX-Jumonji/ARID domain-containing protein 1C protein
ADP + SmcX-Jumonji/ARID domain-containing protein 1C phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + STAT3 protein
ADP + STAT3 phosphoprotein
-
Cdk5 phosphorylates at Ser727
-
-
?
ATP + steroid receptor coactivator-1
ADP + phosphorylated steroid receptor coactivator-1
-
-
-
-
?
ATP + striatin protein
ADP + striatin phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + T-cell protein tyrosine phosphatase
ADP + phosphorylated T-cell protein tyrosine phosphatase
ATP + TATA box-binding protein-associated factor 2F protein
ADP + TATA box-binding protein-associated factor 2F phosphoprotein
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + telomeric repeat binding factor 2 protein
ADP + telomeric repeat binding factor 2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Tipin protein
ADP + Tipin phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + v-raf murine sarcoma viral oncogene homolog B1 protein
ADP + v-raf murine sarcoma viraloncogene homolog B1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Varicella-Zoster virus IE63 protein
ADP + phosphorylated Varicella-Zoster virus IE63 protein
ATP + Whi5 G1 protein
ADP + phosphorylated Whi5 G1 protein
-
-
-
-
?
ATP + Xenopus laevis protein associated with PRK1 protein
ADP + Xenopus laevis protein associated with PRK1 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + zinc finger protein 46 protein
ADP + zinc finger protein 46 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
N6-PhEt-ATP-gamma-S + 1-deoxy-D-xylulose 5-phosphate reductoisomerase
?
-
gene locus At5g62790
-
-
?
N6-PhEt-ATP-gamma-S + 20S proteasome alpha subunit PAD1
?
-
gene locus At3g51260
-
-
?
N6-PhEt-ATP-gamma-S + 5-methyltetrahydropteroyl-triglutamate-homocysteine methyltransferase
?
-
i.e. EC 2.1.1.14, gene locus At517920
-
-
?
N6-PhEt-ATP-gamma-S + aldehyde dehydrogenase 7B4
?
-
gene locus At1g54100
-
-
?
N6-PhEt-ATP-gamma-S + aquaporin interactor
?
-
gene locus At4g38220
-
-
?
N6-PhEt-ATP-gamma-S + beta glucosidase 18
?
-
gene locus At1g52400
-
-
?
N6-PhEt-ATP-gamma-S + fructose-bisphosphate aldolase 2
?
-
gene locus At4g38970
-
-
?
N6-PhEt-ATP-gamma-S + glyceraldehyde-3-phosphate dehydrogenase C2
?
-
gene locus At1g13440
-
-
?
N6-PhEt-ATP-gamma-S + heat shock protein 70
?
-
gene locus At3g09440
-
-
?
N6-PhEt-ATP-gamma-S + isopropylmalate dehydrogenase 1
?
-
gene locus At5g14200
-
-
?
N6-PhEt-ATP-gamma-S + low expression of osmotically responsive genes 2
?
-
gene locus At2g36530
-
-
?
N6-PhEt-ATP-gamma-S + mitochondrial malate dehydrogenase 1
?
-
gene locus At1g53240
-
-
?
N6-PhEt-ATP-gamma-S + NAD(P)-binding Rossmann-fold superfamily protein
?
-
gene locus At5g19440
-
-
?
N6-PhEt-ATP-gamma-S + proline iminopeptidase
?
-
gene locus At2g14260
-
-
?
N6-PhEt-ATP-gamma-S + thioglucoside glucohydrolase 1
?
-
gene locus At5g26000
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
cdk2-cyclin A phosphorylates e.g. protein substrate p107 and peptide substrate PKTPKKAKKL, requiring a small hydrophobic patch RXL, known as a recruitment peptide
-
-
?
ATP + axonal cytoskeleton protein
ADP + phosphorylated axonal cytoskeleton protein
-
-
-
-
?
ATP + axonal cytoskeleton protein
ADP + phosphorylated axonal cytoskeleton protein
-
regulated by integrin alpha1beta1
-
-
?
ATP + bloom syndrome helicase
ADP + phosphorylated bloom syndrome helicase
-
-
-
-
?
ATP + bloom syndrome helicase
ADP + phosphorylated bloom syndrome helicase
-
phosphorylation at Ser-714 and Thr-766, both the N- and C-terminal domains are phosphorylated by Cdc2
-
-
?
ATP + BRCA2
ADP + phosphorylated BRCA2
-
phosphorylates at Ser3291, phosphorylation reaches maximal levels in G2/M
-
-
?
ATP + BRCA2
ADP + phosphorylated BRCA2
-
phosphorylates at Ser3291, an event that disrupts association with RAD51
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
-
-
-
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
-
Cdk7 phosphorylates Ser-5 in the heptad repeats of the C-terminal domain of RNA polymerase II, Cdk9 phosphorylates Ser-2 in the C-terminal domain of RNA RNA polymerase II
-
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
-
-
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
Cdk phosphorylation affects interaction of Cdc20 with Mad2 and the anaphase-promoting complex-cyclosome in HeLa cells
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
in vitro substrate of Cdk1 and Cdk2
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
substrate of Cdk1, rather than of Cdk2
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
in vitro substrate of Cdk1 and Cdk2
-
-
?
ATP + cdk2
ADP + phosphorylated cdk2
-
CDK7 phosphorylates the activation segment or T-loop of CDK2
-
-
?
ATP + Cln3 protein
ADP + Cln3 phosphoprotein
-
recombinant His-tagged Cln3 protein is phosphorylated by Pho85/Pho80 complexes at S449 and T520. Cdc28 phosphorylates Cln3 to a greater extent than Pho85, probably because it phosphorylates Cln3 at more sites in the PEST region than Pho85
-
-
?
ATP + Cln3 protein
ADP + Cln3 phosphoprotein
-
recombinant His-tagged Cln3 protein is phosphorylated by Pho85/Pho80 complexes at S449 and T520. Cdc28 phosphorylates Cln3 to a greater extent than Pho85, probably because it phosphorylates Cln3 at more sites in the PEST region than Pho85
-
-
?
ATP + dephosphin
ADP + phosphorylated dephosphin
-
Cdk5 regulates endocytosis involving dephosphin activity, overview
-
-
?
ATP + early mitotic inhibitor 1 protein
ADP + early mitotic inhibitor 1 phosphoprotein
-
-
-
-
?
ATP + early mitotic inhibitor 1 protein
ADP + early mitotic inhibitor 1 phosphoprotein
-
i.e. Emi1, is phosphorylated by CDKs in mitotic but not S-phase cell extracts
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB3
ADP + phosphorylated ErbB3
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB3
ADP + phosphorylated ErbB3
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + eukaryotic elongation factor 2
ADP + phosphorylated eukaryotic elongation factor 2
-
phosphorylation on Ser595 by Cdk2
-
-
?
ATP + eukaryotic elongation factor 2
ADP + phosphorylated eukaryotic elongation factor 2
-
phosphorylation on Ser595 by Cdk2. Substrate mutant S595A is poorly phosphorylated by cyclin A-CDK2
-
-
?
ATP + Fkh2p
ADP + phosphorylated Fkh2p
-
phosphorylation of forkhead transcription factor Fkh2p is part of regulation of cell cycle-specific gene expression, e.g. of the CLB2 cluster, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation, overview
-
-
?
ATP + Fkh2p
ADP + phosphorylated Fkh2p
-
forkhead transcription factor Fkh2p, C-terminally phosphorylation of Fkh2p promotes interaction with the activator Ndd1p, which becomes also phosphorylated, activity with Fkh2p mutants, overview
-
-
?
ATP + glucocorticoid receptor
ADP + phosphorylated glucocorticoid receptor
-
-
-
-
?
ATP + glucocorticoid receptor
ADP + phosphorylated glucocorticoid receptor
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
commercial substrate
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
substrate of CDK11p110
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of e.g. of cheimeric K-cyclin/cdk6 and K-cyclin-cyclin D2
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
preferred substrate of cdk5 associated with p35
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
commercial substrate, Cdk5
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of CDKB
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of Cdk-A/cyclin D2
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of Cdk-A/cyclin D2 and of proliferating cell nuclear antigen/cyclin D2
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
-
huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
-
huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201
-
-
?
ATP + MAP1B
ADP + phosphorylated MAP1B
-
reaction in growth cones is important for stability of microtubules
-
-
?
ATP + MAP1B
ADP + phosphorylated MAP1B
-
type 1 phosphorylation in the mab1E11 recognition site
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor
-
-
?
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor, purified recombinant PRMT5/MEP50 produced in Sf9 cells or HeLa cells, phosphorylation of Thr5 and perhaps Ser264 by CDK4
-
-
?
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor
-
-
?
ATP + Munc-18
ADP + phosphorylated Munc-18
-
involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
-
phosphorylation at Ser1176 by Cdk5
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
-
phosphorylation at Ser1176 in the sequence RPKTLSPGKN by Cdk5
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 in the consensus sequence RSRSPR by Cdk5, Cdk5 associates with Erb3 in vivo
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 in the sequence AKTPIKWAL and Ser1120 in the consensus sequence RSRSPR by Cdk5, weak phosphorylation of Ser1204 in the proline-rich sequence RRGSPPRPPR
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 by Cdk5
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H peptide
ADP + phosphorylated NF-H peptide
-
i.e. RREAKSPAKAKSPAKE
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NR1 receptor
ADP + phosphorylated NR1 receptor
-
involved in synaptic transmission, overview
-
-
?
ATP + NR2 receptor
ADP + phosphorylated NR2 receptor
-
involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview
-
-
?
ATP + NR2 receptor
ADP + phosphorylated NR2 receptor
-
with phosphorylation sites on both, A and B subunits, e.g. Ser1232 on the A subunit
-
-
?
ATP + parkin
ADP + phosphorylated parkin
-
Ser-131 located at the linker region of parkin is the major Cdk5 phosphorylation site, phosphorylation by Cdk5 decreases the auto-ubiquitylation of parkin, parkin S131A mutant has 40% lower phosphorylation levels in vivo than wild-type parkin
-
-
?
ATP + parkin
ADP + phosphorylated parkin
-
Ser-131 located at the linker region of parkin is the major Cdk5 phosphorylation site, phosphorylation by Cdk5 decreases the auto-ubiquitylation of parkin
-
-
?
ATP + parkin
ADP + phosphorylated parkin
-
parkin has four putative Cdk5 phosphorylation sites according to the motif (S/T)PX(K/R)
-
-
?
ATP + PKTPKKAKKL
ADP + PKpTPKKAKKL
-
GST-tagged recombinant peptide substrate
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
cyclin-dependent kinase activity is required for progesterone receptor PR function, the phosphorylation of the receptor protein has little effect, but cyclin A/Cdk2 acts as a progesterone receptor coactivator via stimulation of PR transcription, Cdk2-cyclin A is PR-dependently recruited to the PR promoter binding to cyclin A, mechanism involving SCR-1 and regulation, overview
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
Cdk2-cyclin A
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
cyclin A2/Cdk2 phosphorylates progesterone receptor in vitro at Ser25, Ser162, Ser190, Ser213, Ser400, Thr 430, Ser554 and Ser676
-
-
?
ATP + protein
ADP + phosphoprotein
-
NIMA is a cell cycle regulated protein kinase required, in addition to p34cdc2/cyclin B, for initiation of mitosis. NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis. NIMA degradation during mitosis is required for correct mitotic progression in Aspergillus nidulans
-
-
?
ATP + protein
ADP + phosphoprotein
the enzyme is likely to be involved in regulating the cell cycle and therefore may have a role in oncogenesis
-
-
-
ATP + protein
ADP + phosphoprotein
serine/threonine-specific protein kinase
-
-
-
ATP + protein
ADP + phosphoprotein
receptor protein tyrosine kinase
-
-
-
ATP + Rad9 protein
ADP + Rad9 phosphoprotein
-
a DNA damage response mediator
-
-
?
ATP + Rad9 protein
ADP + Rad9 phosphoprotein
-
a DNA damage response mediator, phosphorylaation at Thr125 and Thr143
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
-
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites in the cell cycle G1 phase
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, phosphorylation by CDK4/cyclin D
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, recombinant GST-tagged substrate, substrate of e.g. of chimeric K-cyclin/cdk6 and K-cyclin-cyclin D2
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
-
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
the phosphorylation site is at Ser795
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + retinoblastoma phosphoprotein
-
a tumor suppressor protein
-
-
?
ATP + retinoblastoma protein
ADP + retinoblastoma phosphoprotein
-
a tumor suppressor protein, phosphorylated by Cdk5-p25
-
-
?
ATP + retinoblastoma-related protein
ADP + phosphorylated retinoblastoma-related protein
-
i.e. RBR, substrate of Cdk-A/cyclin D2
-
-
?
ATP + retinoblastoma-related protein
ADP + phosphorylated retinoblastoma-related protein
-
i.e. RBR, substrate of Cdk-A/cyclin D2 and of proliferating cell nuclear antigen/cyclin D2
-
-
?
ATP + RhoGEF Tus1p
ADP + phosphorylated RhoGEF Tus1p
-
-
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
phosphorylate the C-terminal domain of RNA polymerase II
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
-
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
CDK9 phosphorylates the carboxy-terminal domain of the largest subunit (RPB1) of RNA polymerase II
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
CDK7 and CDK8 phosphorylate the C-terminal domain of RNA Pol II
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphorylated RNA polymerase II C-terminal domain
-
phosphorylation by Cdk7 and Cdk9, phosphorylation at serine residues 2 and 5
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphorylated RNA polymerase II C-terminal domain
-
reccombinant GST-tagged substrate
-
-
?
ATP + SCR-1
ADP + phosphorylated SCR-1
-
Cdk2-cyclin A, phosphorylation at Lys5 regulates SCR-1 interaction with the progesterone receptor
-
-
?
ATP + SCR-1
ADP + phosphorylated SCR-1
-
Cdk2-cyclin A, phosphorylation at Lys5
-
-
?
ATP + septine 5
ADP + phosphorylated septine 5
-
Ser327 is the major phosphorylation site for Cdk5 in presence of activator p35
-
-
?
ATP + septine 5
ADP + phosphorylated septine 5
-
Ser327 is the major phosphorylation site for Cdk5 in presence of activator p35
-
-
?
ATP + Sic1
ADP + phosphorylated Sic1
-
Glc8 function is dependent on phosphorylation at Thr-118, which is phosphorylated by Pho85 in conjunction with cyclins Pcl6 and Pcl7, and possibly Pcl8 and Pcl10
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3
-
specific phosphorylation at Ser727 by CDK5-p35, CDK5 is involved in regulation of the signal transducer and transcription activator STAT3 in brain and muscle
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3
-
specific phosphorylation at Ser727 by CDK5-p35
-
-
?
ATP + steroidogenic factor 1
ADP + phosphorylated steroidogenic factor 1
-
also known as Ad4BP, systematic name NR5A1, the phosphorylation site is at Ser203
-
-
?
ATP + steroidogenic factor 1
ADP + phosphorylated steroidogenic factor 1
-
also known as Ad4BP, systematic name NR5A1, the phosphorylation site is at Ser203
-
-
?
ATP + T-cell protein tyrosine phosphatase
ADP + phosphorylated T-cell protein tyrosine phosphatase
-
phosphorylation of the two splicing varaints TC45 and TC48 at Ser304 in a cell cycle-dependent manner, optimally in mitosis, overview
-
-
?
ATP + T-cell protein tyrosine phosphatase
ADP + phosphorylated T-cell protein tyrosine phosphatase
-
phosphorylation of the two splicing varaints TC45 and TC48 at Ser304 in the sequence AFDHS(P), no activity with substrate mutant S304A
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
hyperactivated Cdk5-p25
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
Cdk5 phosphorylates at S202, S235, and S404, phosphorylation at S235 primes it for phosphorylation of T231 by GSK3beta, phosphorylating tau protein at S404 primes tau protein for a sequential phosphorylation of S400 and S396 by GSK3beta
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
phosphorylation at Ser235 by cdk5 primes phosphorylation at Thr231 by GSK-3alpha/beta. Tau protein isoforms with the two N-terminal inserts s4L and s3L are more favorable substrates than tau protein isoforms without the inserts. Thr231 is phosphorylated ca. 50% more in free tau protein than in microtubule-bound one
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
hyperactivated Cdk5-p25
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
-
-
?
ATP + Tau protein
ADP + Tau phosphoprotein
-
Cdk5-p25 has a stronger Tau-phosphorylating activity than Cdk5-p35 in neurons
-
-
?
ATP + Tau protein
ADP + Tau phosphoprotein
-
Cdk5-p25 or Cdk5-p35 or Cdk5-p39
-
-
?
ATP + Varicella-Zoster virus IE63 protein
ADP + phosphorylated Varicella-Zoster virus IE63 protein
-
phosphorylation at Ser224 by CDK1 in vivo is required for correct localization of the virus protein, e.g. in the host cytoplasm during latency, S224A mutation leads to inhibition of phosphorylation and exclusive localization of IE63 protein in the nucleus
-
-
?
ATP + Varicella-Zoster virus IE63 protein
ADP + phosphorylated Varicella-Zoster virus IE63 protein
-
recombinant wild-type and mutant IE63 proteins expressed in Vero cells, phosphorylation at Ser224 of wild-type and mutants T222E and T222A by CDK1 and CDK5, but not by CDK2, CDK7, and CDK9 in vitro, mutant S224A is no substrate
-
-
?
ATP + VGCC
ADP + phosphorylated NR1 receptor
-
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel inhibiting interaction with SNARE proteins, SNAP-25, and synaptotagmin I required for neurotransmitter release, overview
-
-
?
ATP + VGCC
ADP + phosphorylated NR1 receptor
-
a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel
-
-
?
ATP + Wee1A
ADP + phosphorylated Wee1A
-
phosphorylation at S123, S53, and S121 promotes binding of Wee1A by beta-TrCP, the beta-transducin repeat-containing protein, which is the substrate recognition component of the ubiquitin ligase, leading to proteasomal degradation of Wee1A, overview
-
-
?
ATP + Wee1A
ADP + phosphorylated Wee1A
-
phosphorylation at S123, S53, and S121
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
the enzyme phosphorylates Ser595. Ser595 phosphorylation varies during the cell cycle and is required for efficient Thr56 phosphorylation (by elongation factor 2 kinase) in vivo
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
the enzyme phosphorylates Ser595
-
-
?
ATP + [tau protein]
ADP + O-phospho-[tau-protein]
-
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26
-
-
?
ATP + [tau protein]
ADP + O-phospho-[tau-protein]
-
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26, phosphorylation at Ser202 and Thr205
-
-
?
ATP + [tau protein]
ADP + [O-phospho-tau protein]
-
substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, tau hyperphosphorylation is involved in neurodegeneration and Alzheimer's disease, tau protein phosphorylation by CDK5 is involved in apoptosis in cortical cells
-
-
?
ATP + [tau protein]
ADP + [O-phospho-tau protein]
-
substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, phosphorylation at the PHF-1 epitope, not the Tau-1 epitope, of tau protein by CDK5-p25
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
cdk5 substrate in brain, cdk5 associated with p39, tau is a microtubule-associated and developmentally regulated protein involved in axonal development in neurons, tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules, reaction of EC 2.7.11.26
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
preferred substrate of cdk5 associated with p39, recombinant bacterially expressed human tau protein as substrate, phosphorylation at Ser202 and Thr205, reaction of EC 2.7.11.26
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
cdk5 associated with p25, cdk5 substrate in brain
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
cdk5 associated with p25, recombinant bacterially expressed human tau protein as substrate, phosphorylation of the AT8 and AT180 epitopes, and at T231 of the Alzheimer's mitotic epitope TG-3
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
activity in organisms with mutated APP and tau, not in wild-type, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
phosphorylation of the PHF-1 epitope at Ser396 and Ser404 by CDK5
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
tau is microtubule-associated, phopshorylation at T231 by CDK5 causes its release into the cytoplasm
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
phosphorylation at T231, no activity with tau mutant T231A
-
-
?
N6-PhEt-ATP-gamma-S + pfkB-like carbohydrate kinase family protein
?
-
gene locus At2g31390
-
-
?
N6-PhEt-ATP-gamma-S + pfkB-like carbohydrate kinase family protein
?
-
gene locus At5g51830
-
-
?
additional information
?
-
-
enzyme may play a role in the regulation of plant growth and development
-
-
-
additional information
?
-
-
enzyme plays a central role in control of the mitotic cell cycle
-
-
-
additional information
?
-
-
key component of the eukaryotic cell cycle, which is required for G1 to S-phase transition and for entry into mitosis
-
-
-
additional information
?
-
-
plant-specific cyclin-dependent kinase CDKB1,1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis thaliana, CDKB1,1 is required to inhibit the endocycle and promote the ectopic cell divisions triggered by E2Fa-DPa, regulation model
-
-
-
additional information
?
-
-
the enzyme interacts with kinesin-like proteins KCA1 and KCA2 and is required for their activity and protein folding, and is influenced by the phosphorylation status of KCA1 and KCA2, the interaction plays a role in the cell cycle and cell division, overview
-
-
-
additional information
?
-
-
the plant-specific kinase CDKF,1 is involved in activating phosphorylation of CDK-activating kinases in Arabidopsis
-
-
-
additional information
?
-
-
the enzyme interacts with kinesin-like proteins KCA1 and KCA2, which possess N-terminal ATP and microtubule binding sites, as well as potential C-terminal CDK phosphorylation sites at positions 698, 849, and 853 in KCA1, and at positions 827 and 831 in KCA2, overview
-
-
-
additional information
?
-
-
the CDKs PHOA is involved in modulation of differentiation in response to environmental conditions, including limited phosphorous, but does not play an essential role in regulation of phosphorous aquisition
-
-
-
additional information
?
-
-
enzyme is required for M phase in meiotic and mitotic cell divisions, but not for S phase
-
-
-
additional information
?
-
-
can properly regulate the cell cycle
-
-
-
additional information
?
-
-
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
-
-
-
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
-
-
-
additional information
?
-
-
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
-
-
-
additional information
?
-
enzyme is involved in Dictyostelium differentiation rather than growth
-
-
-
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
-
-
-
additional information
?
-
-
Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins
-
-
-
additional information
?
-
-
poor activity on free amino acids, consensus sequence of cdk2 is S/TP-XR/K
-
-
-
additional information
?
-
-
multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle, determination of the importance of phosphorylations of regulatory proteins in the cell cycle and biological network, CDK regulation involving positive feedback by Cdc25, Wee1, and CAK, mathematical modeling, overview
-
-
-
additional information
?
-
-
Cdk5 is crucial for stability of axons and growth cones in retina, overview
-
-
-
additional information
?
-
-
CDKA1 is involved in cell cycle regulation and dormancy
-
-
-
additional information
?
-
CDKA1 is involved in cell cycle regulation and dormancy
-
-
-
additional information
?
-
Q8GVD8
CDKA1 is involved in cell cycle regulation and dormancy
-
-
-
additional information
?
-
-
CDKB1 is involved in cell cycle regulation and dormancy
-
-
-
additional information
?
-
CDKB1 is involved in cell cycle regulation and dormancy
-
-
-
additional information
?
-
Q8GVD8
CDKB1 is involved in cell cycle regulation and dormancy
-
-
-
additional information
?
-
the gene coding for the enzyme is a candidate for the following disorders: Nance-Horan syndrome, oral-facial-digital syndrome type 1, and nonsyndromic sensorineural deafness
-
-
-
additional information
?
-
-
CDK4 amplification might contribute to oncogenesis
-
-
-
additional information
?
-
-
mutation of CDK4 can create a tumor-specific antigen and can disrupt the cell-cycle regulation exerted by the tumor suppressor p16INK4a
-
-
-
additional information
?
-
CDK9 is the catalytic subunit of a general RNA polymerase II elongation factor termed p-TEFb which is targeted by the human immunodeficiency virus Tat protein to activate elongation of the integrated proviral genome
-
-
-
additional information
?
-
-
CDK9 is the catalytic subunit of a general RNA polymerase II elongation factor termed p-TEFb which is targeted by the human immunodeficiency virus Tat protein to activate elongation of the integrated proviral genome
-
-
-
additional information
?
-
-
proper regulation of p58 protein kinase is essential for normal cell cycle progression in these cells
-
-
-
additional information
?
-
-
PISSLRE could be involved in processes distinct from cell proliferation
-
-
-
additional information
?
-
human K35-cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth-regulatory signals
-
-
-
additional information
?
-
enzyme plays an important role in spermatogenesis
-
-
-
additional information
?
-
-
TFIIH is a multisubunit complex, containing ATPase, helicases, and kinase subunit of TFIIH. In mitosis the CDK7 subunit of TFIIH and the largest subunit of RNAPII become hyperphosphorylated. MPF-induced phosphorylation of CDK7 results in inhibition of the TFIIH-associated kinase and transcription activities
-
-
-
additional information
?
-
cdk7 is a subunit of the transcription/DNA repair factor TFIIH, cdk7 may phosphorylate the carboxy-terminal domain of RNA pol II in the absence of promoter opening
-
-
-
additional information
?
-
-
abnormal phosphorylation of tau in dividing cells leads to its accumulation in the cytosol as microtubule-free form, Cdk5 is involved in neurodegenerative mechanisms
-
-
-
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering from Alzheimer's disease leads to age-dependent memory deficits
-
-
-
additional information
?
-
-
cdk5 catalyzes tau phosphorylation in brain, but cyclin-dependent phosphorylation of other proteins, EC 2.7.11.22, in different tissues
-
-
-
additional information
?
-
-
CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview
-
-
-
additional information
?
-
-
Cdk1/cyclin B is induced in cells with dysregulated cell cycle, e.g. after infection with the human cytomegalovirus, regulation mechanisms, overview
-
-
-
additional information
?
-
CDK11p110 is involved in transcription and RNA processing
-
-
-
additional information
?
-
-
CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo, CDK11p58 acts as a regulator of HBO1 activity in eukaryotic transcription
-
-
-
additional information
?
-
-
CDK4 governs cell cycle progression through the G1 phase, CDK2 is involved in all cell cycle phases, overview
-
-
-
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 regulates endocytosis through association with amphiphysin and dynamin, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
-
-
-
additional information
?
-
-
CDK6/cyclin D1 enhances the transition of cells through the G1 phase of the cell cycle, CDK6 without bound cyclin D1 associates with the androgen receptor AR and enhances, independently of its kinase activity, its transcriptional activity in presence of dihydrotestosterone in prostate cancer cells, this stimulation is highly exaggerated with AR mutant T877A found in prostate cancer, thus CDK6 is probably important for prostate cancer development, CDK6 is no essential for stimulation of AR, overview
-
-
-
additional information
?
-
-
Cdks are cell cycle regulating enzymes, the spindle checkpoint requires cyclin-dependent kinase activity, regulation overview
-
-
-
additional information
?
-
-
CDKs are cell cycle-related enzymes, CDK5 activity increases 1.6fold within 5 weeks during neuronal cell differentiation induced by retinoic acid, while the activity of CDK1 and CDK2 decreases by 14.4fold, overview
-
-
-
additional information
?
-
-
constitutitve activation of CDK2-cyclin E leads to G1/S deregulation and tumor progression
-
-
-
additional information
?
-
-
herpes simplex virus type 1 ICP0 directs the degradation of cellular proteins associated with nuclear structures called ND10 by transactivation of promoters and gene expression involving cdks, overview, virus replication, of HSV-1, HSV-2, HMCV, and varicella-zoster virus, is inhibited by inhibition of cdks by inhibiting specific steps or activities of viral regulatory proteins, thus cdks have broad and pleiotropic effects on virus replication, overview
-
-
-
additional information
?
-
-
p34SEI-1 is involved in regulation of CDK4-cyclin D2 activity
-
-
-
additional information
?
-
-
the CDKs are involved in regulation of cell cycle and neuronal differentiation
-
-
-
additional information
?
-
-
the CDKs play a central role in cell cycle control, apoptosis, transcription, and neuronal functions
-
-
-
additional information
?
-
-
the polo-kinase 1, EC 2.7.11.21, also phosphorylates Wee1A at S53 and S123, casein kinase II, EC 2.7.11.1, also phosphorylates Wee1A at S121
-
-
-
additional information
?
-
-
there is cross-talk between the NF-kappaB/IkappaBalpha pathway and the p16/CDK4/Rb pathway in cells with IkappaBalpha being capable to substitute for the inhibitory function of p16 on CDK4, regulation
-
-
-
additional information
?
-
-
viral infection causes dysregulation of multiple human host cell cycle-regulatory proteins, cdks are involved in viral replication, overview, cdk is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production
-
-
-
additional information
?
-
-
viral K-cyclin has a much longer half-life compared to cellular cyclins because it lacks the PEST degradation sequence, the viral K-cyclin can substitute the cellular cyclins in binding to the cellular CDKs, which is important for the virus development, chimeric K-cyclin-cdks are also translocated to the nucleus, chimeric K-cyclin/cdk6 kinase is constitutively active in BC cells, chimeric K-cyclin-cyclin D2 can act as a CDK
-
-
-
additional information
?
-
CDK11p110 interacts with Hsp90, and the serine/threonine kinase CK2, the C-terminal domain of the largest subunit of RNA polymerase II is no substrate of CDK11p110, but of CK2
-
-
-
additional information
?
-
-
CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo
-
-
-
additional information
?
-
-
determination and analysis of CDK2 consensus sequence X-S/T(P)-P-X-K/R, modeling of substrate binding, structure analysis
-
-
-
additional information
?
-
-
enzyme cdk2, cdk4, and especially cdk6 interact with the KSHV viral K-cyclin, a homologue of cellular cyclin D, in BC3 cells, K-cyclin also interacts with p21Cip1 and p27Kip1 in the cells, chimeric K-cyclin/cdk6 kinase is constitutively active, chimeric K-cyclin-cyclin D2 can act as a CDK
-
-
-
additional information
?
-
-
kinase properties of Cdk5 are similar to those of Cdk1-cyclin B. Tau and Dab1 are phosphorylated by Cdk5-p39 and Cdk5-p35 at the same sites
-
-
-
additional information
?
-
-
the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview
-
-
-
additional information
?
-
-
the cdc2 protein kinase plays a role in transcriptional regulation
-
-
-
additional information
?
-
enzyme may have a critical function during normal embryonic development and continues to be expressed in differentiated adult tissues
-
-
-
additional information
?
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
-
additional information
?
-
enzyme is involved in signal transduction process of pattern formation in the hindbrain
-
-
-
additional information
?
-
-
naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of mutants leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of mutants leads to age-dependent memory deficits
-
-
-
additional information
?
-
-
cdk5 catalyzes tau phosphorylation in brain, but cyclin-dependent phosphorylation of other proteins, EC 2.7.11.22, in different tissues
-
-
-
additional information
?
-
-
CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview
-
-
-
additional information
?
-
-
Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection
-
-
-
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration
-
-
-
additional information
?
-
-
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
-
-
-
additional information
?
-
no detectable kinase activity towards CDKs, the Pol II carboxyl-terminal domain (CTD), histone H1 or myelin basic protein
-
-
-
additional information
?
-
-
the CDK2-cyclin E complex is a inducer of S-phase entry and key factor for the initiation of centrosome duplication, that CDK4/6-cyclin D are the proteins that compensates for the loss of CDK2 in the initiation of centrosome duplication
-
-
-
additional information
?
-
-
phosphorylation of T161 in plant CDKA is required for activation of its associated kinase
-
-
-
additional information
?
-
-
CDK is involved in control of cell differentiation and organogenesis
-
-
-
additional information
?
-
-
CDKB and CDKA are regulated through phosphorylation and cyclins A and B during the cll cycle, regulation overview
-
-
-
additional information
?
-
-
CDKB ia a B1-type CDK with A-type features
-
-
-
additional information
?
-
-
the enzyme interacts specifically with Cdc kinase subunit 1
-
-
-
additional information
?
-
-
autophosphorylation of Pfmrk, can not phosphorylate PfPK5
-
-
-
additional information
?
-
the enzyme is a component of maturation-promoting factor
-
-
-
additional information
?
-
-
the enzyme is a component of maturation-promoting factor
-
-
-
additional information
?
-
enzyme plays an important role in spermatogenesis
-
-
-
additional information
?
-
Cdk2 protein might be required for entry into the S phase of the cell cycle in FRTL-Tc cells
-
-
-
additional information
?
-
-
CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria during ceramide-mediated neuronal death: neurotoxic calcium transfer from ER to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau, inhibition of the process leads to cell death
-
-
-
additional information
?
-
-
CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview
-
-
-
additional information
?
-
-
Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection
-
-
-
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
-
-
-
additional information
?
-
-
Cdk5-p35 is negatively regulated by interaction with membranes in brain and liver, mechanism
-
-
-
additional information
?
-
-
cyclin-dependent kinase activity is required for apoptotic death involving the retinoblastoma protein but not inclusion formation in cortical neurons after proteasomal inhibition, Cdk2, Cdk4, and Cdk6 promote the apoptosis induced by lactacystin and other proteasome inhibitors, expression of a defective retinoblastoma protein is neuroprotective
-
-
-
additional information
?
-
-
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
-
-
-
additional information
?
-
-
the phosphatidylinositol-linked dopamine receptor is involved in regulation of cdk5 enzyme activity in the brain
-
-
-
additional information
?
-
-
CDK5 induces caspase-independent mitochondrial fission
-
-
-
additional information
?
-
-
enzyme is required for initiation of meiosis and sporulation
-
-
-
additional information
?
-
-
negative regulatory factors of the PHO system
-
-
-
additional information
?
-
-
Kin28 may be a cyclin dependent kinase which is required for cell proliferation
-
-
-
additional information
?
-
enzyme is required for induction of meiosis
-
-
-
additional information
?
-
-
determination of cyclin specificity of Cdk1 during cell cycle using mutant Cdk1-as1 with an enlarged ATP binding site, overview
-
-
-
additional information
?
-
-
determination of cyclin specificity of Cdk1 with different enzyme substrates using mutant Cdk1-as1 with an enlarged ATP binding site, overview
-
-
-
additional information
?
-
-
Cdk activity is required to fire origins of DNA replication and to prevent 'licensing' (establishing the competence) of additional origins after replication initiation
-
-
-
additional information
?
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once-per-cell-cycle replication is enforced by cyclin-Cdk-dependent phosphorylation of the prereplicative complex components Mcm2-7, Cdc6, and Orc1-6
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Cdk1 controls timing of vacuole movement and regulates vacuole inheritance
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Pho85 is a proline-directed kinase that preferentially phosphorylates the consensus sequence S/T-P-X-I/L. Cln3 contains two of these sites (Ser449 and Thr520) located precisely at the ends of the PEST region. Cln3 is an in vitro substrate of Pho85, and both proteins interact in vivo, Cln3 is a molecular target of the Pho85 kinase
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the enzyme requires no phosphorylation for kinase activity
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Pho85 is a proline-directed kinase that preferentially phosphorylates the consensus sequence S/T-P-X-I/L. Cln3 contains two of these sites (Ser449 and Thr520) located precisely at the ends of the PEST region. Cln3 is an in vitro substrate of Pho85, and both proteins interact in vivo, Cln3 is a molecular target of the Pho85 kinase
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enzyme is required for both the G1-S and G2-M transitions during mitotic growth, and also for the second meiotic nuclear division
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the enzyme is required during both G1 and G2 phases of the cell division cycle
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csk1 may encode a protein kinase physically associated with mcs2 or alternatively may function as an upstream activator of the mcs2-associated kinase
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Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
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cdc2-related kinase 12 autophosphorylates in vivo
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enzyme may be involved in controlling aspects of the cell cycle which are linked to the differentiation of the parasite during its complex life cycle
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enzyme may be involved in controlling aspects of the cell cycle which are linked to the differentiation of the parasite during its complex life cycle
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additional information
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enzyme may be involved in controlling aspects of the cell cycle which are linked to the differentiation of the parasite during its complex life cycle
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additional information
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enzyme is involved in controlling aspects of the cell cycle which are linked to the differentiation of the parasite during its complex life cycle
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additional information
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enzyme is involved in controlling aspects of the cell cycle which are linked to the differentiation of the parasite during its complex life cycle
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additional information
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enzyme is involved in controlling aspects of the cell cycle which are linked to the differentiation of the parasite during its complex life cycle
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additional information
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cdc2-related kinase 12 autophosphorylates in vivo
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enzyme is required both for entry into S phase and mitosis
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enzyme is involved in negative regulation of meiotic maturation of Xenopus oocytes
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Cdks are cell cycle regulating enzymes, Cdk1 phosphorylates the anaphase-promoting complex-cyclosome during mitosis, which is a prerequisite for its activity but reduces the anaphase-promoting complex-cyclosome interaction with Cdc20 involving Mad2, the spindle checkpoint requires cyclin-dependent kinase activity, inhibition of Cdk overrides checkpoint-dependent arrest in eggs increasing the interaction of the anaphase-promoting complex-cyclosome with Cdc20, regulation overview
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identification 35 substrates from screening for cyclin B/CDK1, and investigation of the differential specificity of cyclin B/CDK1 versus cyclin A/CDK1 and cyclin A/CDK2. About half the substrates are equally well phosphorylated regardless of the cyclin or the CDK, computational analysis, overview
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Cdk-A/cyclin D2 is involved in DNA replication progress and cell proliferation