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Enzyme Nomenclature
Information on EC 2.7.11.22 - cyclin-dependent kinase
for references in articles please use BRENDA:EC2.7.11.22
Word Map on EC 2.7.11.22
- 2.7.11.22
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cyclins
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p27kip1
- carcinoma
- retinoblastoma
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mitosis
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cell-cycle
- breast
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checkpoint
- histone
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p16ink4a
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hyperphosphorylation
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exit
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s-phase
- leukemia
- chromatin
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deregulation
- tumorigenesis
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mitogen-activated
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antiproliferative
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hypophosphorylated
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mapks
- alzheimer
- prostate
- melanoma
- xenopus
- caspase-3
- oocyte
- tumour
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quiescent
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xenograft
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fission
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interphase
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mitogen
- proteasome
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p21waf1
- spindle
- microtubule
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squamous
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cytokinesis
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aurora
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polo-like
- medicine
- centrosome
- analysis
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metaphase
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cdc25c
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p53-independent
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anaphase
- drug development
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prophase
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oncoproteins
- pharmacology
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postmitotic
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cycle-dependent
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
2.7.11.22
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RECOMMENDED NAME
GeneOntology No.
cyclin-dependent kinase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
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-
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ATP + a protein = ADP + a phosphoprotein
activation involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated at a Thr residue, phosphorylation leads to enzyme inhibition
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ATP + a protein = ADP + a phosphoprotein
active site amino acid sequences of PK5 and mrk
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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CAS REGISTRY NUMBER
COMMENTARY
150428-23-2
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
marine unicellular green algae strain isolated from the Thau lagoon, cyclin-dependent kinases CDKB and CDKA, as well as cyclin A and cyclin B are single copy genes, probably two isoforms of CDKA exist
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490800, 660948, 662152, 662855, 663933, 664005, 664030, 664179, 664536, 664689, 664955, 665053, 665497, 665840, 665968, 665977, 665982, 666109, 666184, 666185, 666347, 666467, 666468, 666728, 666744, 666862, 677617, 678181, 678926, 679021, 679024, 679026, 679092, 679842, 679989, 680759, 681676, 681873, 681881, 682579, 682872, 690991, 691272, 691801, 693903, 694510, 707843, 707917, 707985, 707997, 708631, 708648, 708751, 709090, 709585, 721962, 721986, 722123, 722194, 722706, 722744, 722908, 723022, 723073, 723178, 723580, 723656, 723745, 737959, 738159, 738935, 739062
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491508, 491509, 491510, 491511, 491512, 491513, 491514, 491515, 491516, 491517, 491518, 491519, 491520, 665980, 681873, 691272, 691293, 691302, 694491, 695013, 695048
SwissProt
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662124, 662688, 662855, 664179, 664536, 665488, 666467, 666718, 691105, 691430, 693022, 693746, 693747, 693758, 693762, 707637, 708041, 709335, 721962, 723022
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664179, 664536, 665488, 666124, 666401, 666467, 678181, 680759, 681935, 682872, 691554, 691679, 693721, 693746, 693758, 693779, 695204, 708842, 709637, 710113
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
evolution
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cyclin-dependent kinase 5 belongs to a family of proline-directed serine/threonine kinases
evolution
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primate herpesviruses, including the oncogenic Kaposi sarcoma herpesvirus, encode cyclinDhomologues. Viral cyclins have diverged from their cellular progenitor in that they elicit holoenzyme activity independent of activating phosphorylation by the CDK-activating kinase and resistant to inhibition by CDK inhibitors
evolution
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cyclin-dependent kinase 5, Cdk5, is a member of the family of Cdks. Cdks are proline-directed Ser/Thr protein kinases that are activated by binding a regulatory subunit called cyclin, comparison of neuronal and cycling Cdks, overview. Cdk5 may have evolved from cycling Cdks to function in post-mitotic neurons
evolution
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cyclin-dependent kinase 5, Cdk5, is a member of the family of Cdks. Cdks are proline-directed Ser/Thr protein kinases that are activated by binding a regulatory subunit called cyclin, comparison of neuronal and cycling Cdks, overview. Cdk5 may have evolved from cycling Cdks to function in post-mitotic neurons
malfunction
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cdk5 knockdown results in supernumerary spinal and cranial motor neurons. While a dominant negative, kinase-dead cdk5 promotes the generation of supernumerary motor neurons, over-expression of cdk5 suppresses motor neuron development
malfunction
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the inhibition of cdk-5 activity has neuroprotective effect on neurons in Niemann-Pick disease type C mice
malfunction
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inhibition of cyclin-dependent kinases 7 and 9 drives apoptosis to promote resolution of inflammation, CDK and protein synthesis inhibitors induce neutrophil apoptosis, overview. Cdk inhibitor R-roscovitine affects global gene transcription in LPS-stimulated and -unstimulated primary human neutrophils, overview
malfunction
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differentiated SHSY5Y cells and human neurons show increased cell death from DNA damage induced by camptothecin treatment when Cdk5 is knocked down with siRNA. Increased sensitivity against UV-irradiation is also observed in neurons and other terminally differentiated cells such as podocytes when the expression of Cdk5 and its activators p35 or cyclin I are reduced with siRNA. Knockout of Cdk5 or p35 results in inverted layers of neurons in the cerebral cortex. Longterm inactivation of Cdk5 triggers cell death as well as hyperactivation of Cdk5 by p25. Pro-death activity is suppressed by membrane association of Cdk5 via myristoylation of p35
malfunction
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Cdk5 null mice exhibit perinatal lethality with abnormal positioning of neurons in the brain. Ballooned perikarya of large neurons in the brainstem and cytoplasmic vacuoles in brain nuclei are described for Cdk5 null mice. Similar phenotypes were also observed in the p35-/- p39-/- double null mutant
malfunction
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treatment of leaf cells with a CDK inhibitor or induction of dominant-negative CDKA1 protein inhibits not only cell cycle progression but also tip growth and protonemal gene expression
malfunction
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inhibition of CDK activity at the shoot apex results in premature differentiation of shoot apical meristem cells. Cell-cycle inhibition in the STM domain affects cell division in the meristem and the developing organs
malfunction
Q140014
isoform CDK12 depletion leads to a loss of expression of RNA processing factors and to defects in RNA processing; isoform CDK13 depletion leads to a loss of expression of RNA processing factors and to defects in RNA processing
malfunction
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enzyme depletion results in enlargement of the flagellar pocket and defects in endocytosis
malfunction
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inhibition of CDK activity at the shoot apex results in premature differentiation of shoot apical meristem cells. Cell-cycle inhibition in the STM domain affects cell division in the meristem and the developing organs
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malfunction
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treatment of leaf cells with a CDK inhibitor or induction of dominant-negative CDKA1 protein inhibits not only cell cycle progression but also tip growth and protonemal gene expression
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malfunction
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enzyme depletion results in enlargement of the flagellar pocket and defects in endocytosis
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metabolism
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the primary cellular mechanism that restricts cyclin D1/CDK4 activity is cytoplasmic, ubiquitin-mediated degradation of cyclin D1 during S-phase. Mutations that disrupt this event, via within the cyclin D1 degron or inactivating the cyclin D1 E3 ligase, Fbx4, directly contribute to neoplastic growth
metabolism
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the primary cellular mechanism that restricts cyclin D1/CDK4 activity is cytoplasmic, ubiquitin-mediated degradation of cyclin D1 during S-phase. Mutations that disrupt this event, via within the cyclin D1 degron or inactivating the cyclin D1 E3 ligase, Fbx4, directly contribute to neoplastic growth
metabolism
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cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription
metabolism
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cell cycle regulation is characterized by alternating activities of cyclin-dependent kinases and of the ubiquitin ligase anaphase promoting complex/cyclosome, overview. The latter is inhibited during S-phase by early mitotic inhibitor 1, which is negatively regulated by phosphorylation through CDKs, allowing the accumulation of cyclins A and B and to prevent re-replication, overview
metabolism
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cycling Cdks and neuronal Cdk5 are inversely expressed during neuronal differentiation. Upon neuronal differentiation, cycling Cdks, which are active in proliferating neuronal precursor cells, are down-regulated and Cdk5-p35 is upregulated
metabolism
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cycling Cdks and neuronal Cdk5 are inversely expressed during neuronal differentiation. Upon neuronal differentiation, cycling Cdks, which are active in proliferating neuronal precursor cells, are down-regulated and Cdk5-p35 is upregulated
metabolism
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S595 phosphorylation may globally couple the cell cycle machinery to regulatory pathways that impact eEF2K activity, eEF2 S595 phosphorylation is increased in mitosis. Cyclin A-CDK2 shuttles from the cytoplasm to the nucleus and could phosphorylate eEF2 in interphase cells
metabolism
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activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Cell cycle progression is not required for acquisition of protonema cell-type characteristics
metabolism
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cyclin-dependent kinase subunit 1 and 2 natural overexpression in human mammary epithelial and breast cancer-derived cells, as well as in other cell types, leads to override of the intra-S-phase checkpoint that blocks DNA replication in response to replication stress. Specifically, binding of Cks1 or Cks2 to cyclin-dependent kinase 2 confers partial resistance to the effects of inhibitory tyrosine phosphorylation mediated by the intra-S-phase checkpoint, allowing cells to continue replicating DNA even under conditions of replicative stress, a mechanism contributing to tumor development. Cks protein overexpression does not affect checkpoint signaling through modulation of Cdk2 inhibitory phosphorylation
metabolism
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activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Cell cycle progression is not required for acquisition of protonema cell-type characteristics
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physiological function
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cdk5 plays a critical role in spinal and cranial motor neuron development
physiological function
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CDK1 and CDK2 have integral roles in the cell cycle, putative roles in transcriptional regulation and a controversial role in apoptosis. CDK5 is involved in apoptosis, transcription, differentiation, and endocytosis. CDK7 is a CDK-activating kinase responsible for enhancing the kinase activity of CDK1 and 2. CDK7 associated with cyclin H and MAT1 is responsible for initiation of transcription by the holoenzyme RNA Pol II. Regulation of transcription of Mcl-1 and involvement in pivotal inflammatory signalling via NF-kappaB are functions of CDK7 and CDK9. CDK4 and CDK6 are required for progression through G1 phase. CDK3 is implicated in G0 exit and G1/S phase transition in the cell cycle, CDK10 has a role in transition from G2 to M phase. CDK11 has potentially dual roles in transcription that do not involve direct phosphorylation of RNA polymerase II C-terminal domain.
physiological function
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nuclear cyclin D1/CDK4-dependent repression of CUL4A and CUL4B, encoding scaffolding proteins for the E3 ligase that directs CDT1 degradation during S-phase, the repression requires S-phase accumulation of catalytically active cyclin D1/CDK4, molecular mechanism, overview. Cyclin D1/CDK4 can increase histone methyltransferase activity of PRMT5/MEP50, a PRMT5 co-regulatory factor, through phosphorylation of Thr5 and perhaps through Ser264, and increased PRMT5 activity mediates key events associated with cyclin D1-dependent neoplastic growth including CUL4 repression, CDT1 overexpression, and DNA re-replication. Cyclin D1T286A/CDK4 regulates PRMT5 methyltransferase activity via MEP50 phosphorylation, overview
physiological function
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nuclear cyclin D1/CDK4-dependent repression of CUL4A and CUL4B, encoding scaffolding proteins for the E3 ligase that directs CDT1 degradation during S-phase, the repression requires S-phase accumulation of catalytically active cyclin D1/CDK4, molecular mechanism, overview. Phosphorylation of MEP50, a PRMT5 co-regulatory factor, by CDK4 increases PRMT5/MEP50 activity, and increased PRMT5 activity mediates key events associated with cyclin D1-dependent neoplastic growth including CUL4 repression, CDT1 overexpression, and DNA re-replication
physiological function
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cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription, overview
physiological function
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role of CDK2 cytoplasmic relocalization in the antiproliferative effects of 1,25-dihydroxyvitamin D3. Central roles for CDK2 nuclear-cytoplasmic trafficking and cyclin E in the mechanism of 1,25-dihydroxyvitamin D3-mediated growth inhibition in prostate cancer cells
physiological function
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CDK-mediated phosphorylation of early mitotic inhibitor 1 prevents its binding to ubiquitin ligase anaphase promoting complex/cyclosome
physiological function
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cyclin/cyclin-dependent kinase (CDK) complexes are critical regulators of cellular proliferation. A complex network of regulatory mechanisms has evolved to control their activity, including activating and inactivating phosphorylation of the catalytic CDK subunit and inhibition through specific regulatory proteins, molecular mechanism, overview
physiological function
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primate herpesviruses, including the oncogenic Kaposi sarcoma herpesvirus, encode cyclinDhomologues. Viral cyclins have diverged from their cellular progenitor in that they elicit holoenzyme activity independent of activating phosphorylation by the CDK-activating kinase and resistant to inhibition by CDK inhibitors, molecular mechanism, overview
physiological function
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Cdk5 regulates multiple neuronal activities neuronal migration, neurite extension, and synapse formation during brain development, as well as in synaptic activities in mature neurons and neuronal cell death in neurodegenerative diseases, and it controls life and death of the neuronal cells, pro-death activities of Cdk5-p25, overview. Knockdown of Cdk5 by siRNA reduces the number of Rohon-Beard spinal sensory neurons and increases the number of apoptotic neurons in the brain. When global ischemia is induced by occlusion, Cdk5 death activity occurs in the cytoplasm but not in the nucleus, thus the pro-death activity of Cdk5 depends on the cellular localization of the active Cdk5 complex and death signaling. Cdk5 is required for phosphorylation of signal transduction and activation of transcription 3, STAT3, also related to the pathogenesis of Alzheimer's disease, Cdk5-p35 activity functions as a survival factor in a cell-death model of neurodegenerative disorders. Up-regulated Cdk5 induces phosphorylation of STAT3 at Ser727 to bind the BACE1 promoter, which enhances BACE1 transcription and leads to an increase in protein and activity of BACE1, ultimately resulting in amyloid beta production. Cdk5-p25 phosphorylates p53 on Ser15, Ser33, and Ser44, and phosphorylated p53 is prevented from Hdm-2-mediated ubiquitination and proteasomal degradation in SH-SY5Y cells
physiological function
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Cdk5 appears to be involved in the regulation of neuronal survival both during neuronal development and under stress conditions
physiological function
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PP2A enhancement of CDK8 is independent of RV-cyclin expression and likely plays a role in the normal regulation of CDK8
physiological function
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the phosphate-activated cyclin-dependent kinase Pho85 stabilizes G1 cyclin to trigger cell cycle entry, Pho85 does not control Cln3 stability through regulation of autophagy. The activity of Pho85 is essential for accumulating Cln3 and for reentering the cell cycle after phosphate refeeding. Cln3 is a molecular target of the Pho85 kinase that is required to modulate cell cycle entry in response to environmental changes in nutrient availability
physiological function
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Ser595 phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase through T56 phosphorylation. S595 phosphorylation varies during the cell cycle and is required for efficient T56 phosphorylation in vivo, T56 phosphorylation inactivates eEF2 and is the only known normal eEF2 functional modification. S595 phosphorylation facilitates T56 phosphorylation by recruiting eEF2K to eEF2.
physiological function
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the activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Leaf cells facing the cut undergo CDK activation along with induction of a D-type cyclin, tip growth, and transcriptional activation of protonema-specific genes, CDKA regulates protonema-specific genes and tip growth, as well as cell cycle progression and other cellular changes in parallel. But iozymes CDKA;1 and CDKA;2 are expressed before cutting and activated afterwards
physiological function
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a specific G2/M form of Cdc28 can phosphorylate in vitro the N-terminal region of Rad9 on nine consensus CDK phosphorylation sites, N-terminal CDK consensus sites are phosphorylated by Cdc28/Clb2 and are required for activation of Chk1. The integrity of CDK consensus sites and the activity of Cdc28 are required for both the activation of the Chk1 checkpoint kinase and its interaction with Rad9. Phosphorylation of T143 is the most important feature promoting Rad9/Chk1 interaction, while the much more abundant phosphorylation of the neighbouring T125 residue impedes the Rad9/Chk1 interaction. CDK-dependent activation of Chk1 controls Rad9/Chk1 interaction
physiological function
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CDK9 is a component of the P-TEFb complex involved in transcriptional regulation. CDK9 activity is a key regulator of neutrophil lifespan, preventing apoptosis by maintaining levels of short lived anti-apoptotic proteins such as Mcl-1. Upon association with its activating partner cyclin T1, CDK9 forms P-TEFb, a general transcription factor responsible for phosphorylating the C-terminal domain of RNA polymerase II
physiological function
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the enzyme plays a role during cell division in diatoms. Enzyme overexpression reduces the cell growth rate by interfering with G2/M phase progression
physiological function
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enzyme Cdk3 is essential for the initiation of meiosis in Tetrahymena thermophile
physiological function
Q140014
isoform CDK12 affects RNA processing through direct physical interactions with RNA processing factors and by regulating their expression; isoform CDK13 affect RNA processing through direct physical interactions with RNA processing factors and by regulating their expression
physiological function
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cdc2-related kinase 12 is an essential protein in bloodstream stage Trypanosoma brucei
physiological function
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the activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Leaf cells facing the cut undergo CDK activation along with induction of a D-type cyclin, tip growth, and transcriptional activation of protonema-specific genes, CDKA regulates protonema-specific genes and tip growth, as well as cell cycle progression and other cellular changes in parallel. But iozymes CDKA;1 and CDKA;2 are expressed before cutting and activated afterwards
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physiological function
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the phosphate-activated cyclin-dependent kinase Pho85 stabilizes G1 cyclin to trigger cell cycle entry, Pho85 does not control Cln3 stability through regulation of autophagy. The activity of Pho85 is essential for accumulating Cln3 and for reentering the cell cycle after phosphate refeeding. Cln3 is a molecular target of the Pho85 kinase that is required to modulate cell cycle entry in response to environmental changes in nutrient availability
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physiological function
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enzyme Cdk3 is essential for the initiation of meiosis in Tetrahymena thermophile
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physiological function
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cdc2-related kinase 12 is an essential protein in bloodstream stage Trypanosoma brucei
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additional information
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amino acids in cluster A and B modulate substrate recognition and specificity. Substrate phosphorylation by CDK6 with K-cyclin from Kaposi sarcoma herpesvirus, K-cyclin expression in U2OS cells leads to fragmentation of actin stress fibers
additional information
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Cdk5 is a proline-directed Ser/Thr protein kinase that is activated by binding to a regulatory subunit p35 or p39, activation mechanism of Cdk5, overview
additional information
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inhibition of CDK9 with flavopiridol does not result in loss of Bcl2A
additional information
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Cks1 subunit is involved in SCF-dependent degradation of Cdk inhibitors, while Cks2 subunit is not. Cks1 deficiency is protective against tumor development in genetically engineered mouse models of lymphoma and mammary tumorigenesis
additional information
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effect of ginsenosides on Alzheimer's disease may be involved with the regulation of activities of cdk5/p25. Enzyme activity measurement by mass spectrometry, UPLC/TQMS method development, usage with liquid chromatographic separation of product, overview
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acidic alpha-syntrophin protein
ADP + acidic alpha-syntrophin phosphoprotein
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substrate of cyclinA/CDK2, not of cyclin E/CDK2
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-
?
ATP + ADAQHATPPKKKRKVEDPKDF
ADP + ADAQHAT(P)PPKKKRKVEDPKDF
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a histone peptide substrate
-
-
?
ATP + ADP-ribosylation factor GTPase activating protein 3 protein
ADP + ADP-ribosylation factor GTPase activating protein 3 phosphoprotein
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substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + AE binding protein 2 protein
ADP + AE binding protein 2 phosphoprotein
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substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + APEX nuclease protein
ADP + APEX nuclease phosphoprotein
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substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ARAF serine/threonine protein kinase protein
ADP + ARAF serine/threonine protein kinase phosphoprotein
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substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ATRIP protein
ADP + ATRIP phosphoprotein
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substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + B-cell lymphoma protein 2
ADP + phosphorylated B-cell lymphoma protein 2
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B-cell lymphoma protein 2 is phosphorylated at Ser70, Cdk5-mediated B-cell lymphoma protein 2 phosphorylation is pivotal for the antiapoptotic effect of Bcl-2 and contributes to the maintenance of neuronal survival by Cdk5
-
-
?
ATP + biotin-TVSEESNVLCLSKSPNKHNRLYMKARPFF
ADP + biotin-TVSEESNVLCLSKpSPNKHNRLYMKARPFF
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-
phosphorylated on Ser595
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
ATP + CAK
ADP + phosphorylated CAK
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substrate of cyclin-dependent kinase cdk7
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-
?
ATP + CALD1 protein
ADP + CALD1 phosphoprotein
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reccombinant human GST-tagged substrate, with CDK6
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-
?
ATP + cAMP responsive element binding protein 3-like 2 protein
ADP + cAMP responsive element binding protein 3-like 2 phosphoprotein
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substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + CCAAT/enhancer binding protein gamma protein
ADP + CCAAT/enhancer binding protein gamma phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
phosphorylation of Thr161
-
-
-
ATP + cdc2 PK
ADP + phosphorylated cdc2 PK
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substrate of cyclin-dependent kinase activating kinase CAK
-
-
?
ATP + cdc2-like protein
ADP + phosphorylated cdc2-like protein from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
-
-
-
ATP + CDK1
ADP + phosphorylated CDK1
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CDK7 phosphorylates the activation segment or T-loop of CDK1
-
-
?
ATP + coiled-coil domain protein 52 protein
ADP + coiled-coil domain protein 52 phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + collapsing response mediator protein
ADP + phosphorylated collapsing response mediator protein
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-
-
-
?
ATP + CPEB-associated factor Maskin protein
ADP + CPEB-associated factor Maskin phosphoprotein
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substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + cyclin dependent kinase 2
ADP + phosphorylated cyclin dependent kinase 2
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cyclin activating kinase CAK phosphorylates Thr160 of cdk2, a prerequisite for cell cycle control
-
-
?
ATP + cyclin-dependent kinase
ADP + phosphorylated cyclin-dependent kinase
-
-
-
-
?
ATP + diacylglycerol kinase epsilon protein
ADP + diacylglycerol kinase epsilon phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + diphthamide biosynthesis protein 2 isoform a protein
ADP + diphthamide biosynthesis protein 2 isoform a phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + distal-less homeobox 1 isoform 1 protein
ADP + distal-less homeobox 1 isoform 1 phosphoprotein
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substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + dopamine
ADP + phosphorylated dopamine
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phosphorylation by cdk5
-
-
?
ATP + dopamine and cAMP-regulated phosphoprotein
ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34
-
-
?
ATP + Erp1/emi2 protein
ADP + Erp1/emi2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + establishment of cohesion-1 homologue 2 protein
ADP + establishment of cohesion-1 homologue 2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + estrogen receptor
ADP + phosphorylated estrogen receptor
-
Cdk2 phosphorylation at Ser104 and Ser106
-
-
?
ATP + ETS variant gene-1 protein
ADP + ETS variant gene-1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + ezrin
ADP + phosphorylated ezrin
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phosphorylation by cdk5 at Thr235 in the NH2-terminal region and consequent dissociation of Rho GDP dissociation inhibitor from an ezrin/Rho-GDI complex
-
-
?
ATP + Fizzy1 protein
ADP + Fizzy1 phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + glucocorticoid receptor
ADP + dephosphorylated glucocorticoid receptor
-
CDK5 phosphorylates glucocorticoid receptor at multiple serines, including Ser203 and Ser211 of its N-terminal domain, and suppresses the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to DNA
-
-
?
ATP + glycogenin protein
ADP + glycogenin phosphoprotein
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + granulin isoform 1 precursor protein
ADP + granulin isoform 1 precursor phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + heat shock transcription factor 1 protein
ADP + heat shock transcription factor 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Hermes protein
ADP + Hermes phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + high-molecular-weight neurofilament
ADP + phosphorylated high-molecular-weight neurofilament
-
-
-
-
-
ATP + histone deacetylase 6 protein
ADP + histone deacetylase 6 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + histone H1-derived peptide
ADP + histone H1-derived peptide phosphate
-
-
-
-
?
ATP + histone stem-loop binding protein
ADP + histone stem-loop binding phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + human cytomegalovirus tegument protein pp65
ADP + phosphorylated human cytomegalovirus tegument protein pp65
-
-
-
-
?
ATP + Kunitz type serine protease inhibitor 2 protein
ADP + Kunitz type serine protease inhibitor 2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + lamina-associated protein 2-beta isoform protein
ADP + lamina-associated protein 2-beta isoform phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + LOC222229 protein
ADP + LOC222229 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + low density lipoprotein receptor adaptor protein 1 protein
ADP + low density lipoprotein receptor adaptor protein 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + MAP/microtubule affinity regulating kinase 3 protein
ADP + MAP/microtubule affinity regulating kinase 3 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + maternal embryonic leucine zipper kinase protein
ADP + maternal embryonic leucine zipper kinase phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + MGC86234 protein
ADP + MGC86234 phosphoprotein
-
i.e. potassium channel tetramerisation domaincontaining 3, substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + microtubule-associated tau
ADP + phosphorylated microtubule-associated tau
-
-
-
-
-
ATP + mini-chromosomemaintenance protein 2
ADP + phosphorylated mini-chromosomemaintenance protein 2
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 3
ADP + phosphorylated mini-chromosomemaintenance protein 3
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 4
ADP + phosphorylated mini-chromosomemaintenance protein 4
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 5
ADP + phosphorylated mini-chromosomemaintenance protein 5
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 6
ADP + phosphorylated mini-chromosomemaintenance protein 6
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 7
ADP + phosphorylated mini-chromosomemaintenance protein 7
-
-
-
-
?
ATP + minor histocompatibility antigen HA-1 protein
ADP + minor histocompatibility antigen HA-1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + neurofilament heavy chain
ADP + phosphorylated neurofilament heavy chain
-
-
-
-
?
ATP + neuronal cytoskeletal protein NF-H
ADP + phosphorylated neuronal cytoskeletal protein NF-H
-
-
-
-
ATP + neuronal cytoskeletal protein tau
ADP + phosphorylated neuronal cytoskeletal protein tau
-
-
-
-
ATP + neuronal cytoskeletal proteins NF-M
ADP + phosphorylated neuronal cytoskeletal protein NF-M
-
-
-
-
ATP + origin recognition complex 1
ADP + phosphorylated origin recognition complex 1
-
-
-
-
?
ATP + origin recognition complex 2
ADP + phosphorylated origin recognition complex 2
-
-
-
-
?
ATP + origin recognition complex 3
ADP + phosphorylated origin recognition complex 3
-
-
-
-
?
ATP + origin recognition complex 4
ADP + phosphorylated origin recognition complex 4
-
-
-
-
?
ATP + origin recognition complex 5
ADP + phosphorylated origin recognition complex 5
-
-
-
-
?
ATP + origin recognition complex 6
ADP + phosphorylated origin recognition complex 6
-
-
-
-
?
ATP + p35 protein
ADP + p35 phosphoprotein
-
a nuclear transcription factor, Cdk5-p25 phosphorylates p53 on Ser15, Ser33, and Ser44
-
-
?
ATP + palmitoylated membrane protein 1 protein
ADP + palmitoylated membrane protein 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + PASCIN protein
ADP + PASCIN phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Pho81
ADP + phosphorylated Pho81
-
-
phosphorylated Pho81 is an inhibitor for Pho85
-
?
ATP + phosphatidylinositol-4-phosphate 5-kinase type IIba protein
ADP + phosphatidylinositol-4-phosphate 5-kinase type IIba phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + PIF1 protein
ADP + PIF1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + polymerase II C-terminal domain
ADP + phosphorylated polymerase II C-terminal domain
Q140014
-
-
-
?
ATP + POM21 protein
ADP + POM21 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + pre-B-cell leukemia transcription factor 1 protein
ADP + pre-B-cell leukemia transcription factor 1 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin B/CDK1
-
-
?
ATP + pre-synaptic P/Q-type voltage-dependent calcium channel
ADP + phosphorylated pre-synaptic P/Q-type voltage-dependent calcium channel
-
-
-
-
?
ATP + promyelocytic leukemia zinc finger
ADP + phosphorylated promyelocytic leukemia zinc finger
-
can also be phosphorylated by CDK1 albeit in a less efficient fashion than by CDK2
-
-
?
ATP + Rb peptide
ADP + Rb phosphopeptide
-
from retinoblastoma-associated protein
-
-
?
ATP + RNA polymerase 1 protein
ADP + RNA polymerase 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphorylated RNA polymerase II C-terminal domain
ATP + RNA polymerase II C-terminal domain protein
ADP + RNA polymerase II C-terminal domain phosphoprotein
-
-
-
-
?
ATP + RNA polymerase II carboxy-terminal domain
ADP + phosphorylated RNA polymerase II carboxy-terminal domain
-
CDK8
-
-
?
ATP + RNA polymerase II largest subunit
ADP + phosphorylated RNA polymerase II largest subunit
specifically hyperphosphorylates the carboxyl-terminal
-
-
-
ATP + RXL motif-containing peptide
ADP + RXL motif-containing phosphopeptide
-
peptide sequence corresponding to amino acids 866-880 of RNA polymerase II C-terminal domain. Substrate phosphorylation by CDK6 with K-cyclin from Kaposi sarcoma herpesvirus, but addition of this peptide significantly reduces substrate phosphorylation by cyclin E-CDK2 and cyclin D2-CDK6
-
-
?
ATP + SEC14-like 1 isoform a protein
ADP + SEC14-like 1 isoform a phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + semaphorin 6D protein
ADP + semaphorin 6D phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + Sept5 protein
ADP + phosphorylated Sept5 protein
-
Sept5 protein is phosphorylated at Ser17
-
-
?
ATP + similar to bicaudal C homologue 1 protein
ADP + similar to bicaudal C homologue 1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + similar to peroxisomal biogenesis factor 5 protein
ADP + similar to peroxisomal biogenesis factor 5 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Trigger of mitotic entry 1 protein
ADP + similar to Trigger of mitotic entry 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Zinc finger protein 516 protein
ADP + similar to Zinc finger protein 516 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 protein
ADP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + SmcX-Jumonji/ARID domain-containing protein 1C protein
ADP + SmcX-Jumonji/ARID domain-containing protein 1C phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + STAT3 protein
ADP + STAT3 phosphoprotein
-
Cdk5 phosphorylates at Ser727
-
-
?
ATP + steroid receptor coactivator-1
ADP + phosphorylated steroid receptor coactivator-1
-
-
-
-
?
ATP + striatin protein
ADP + striatin phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + T-cell protein tyrosine phosphatase
ADP + phosphorylated T-cell protein tyrosine phosphatase
ATP + TATA box-binding protein-associated factor 2F protein
ADP + TATA box-binding protein-associated factor 2F phosphoprotein
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + telomeric repeat binding factor 2 protein
ADP + telomeric repeat binding factor 2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Tipin protein
ADP + Tipin phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + v-raf murine sarcoma viral oncogene homolog B1 protein
ADP + v-raf murine sarcoma viraloncogene homolog B1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Varicella-Zoster virus IE63 protein
ADP + phosphorylated Varicella-Zoster virus IE63 protein
ATP + Whi5 G1 protein
ADP + phosphorylated Whi5 G1 protein
-
-
-
-
?
ATP + Xenopus laevis protein associated with PRK1 protein
ADP + Xenopus laevis protein associated with PRK1 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + zinc finger protein 46 protein
ADP + zinc finger protein 46 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
N6-PhEt-ATP-gamma-S + 1-deoxy-D-xylulose 5-phosphate reductoisomerase
?
-
gene locus At5g62790
-
-
?
N6-PhEt-ATP-gamma-S + 20S proteasome alpha subunit PAD1
?
-
gene locus At3g51260
-
-
?
N6-PhEt-ATP-gamma-S + 5-methyltetrahydropteroyl-triglutamate-homocysteine methyltransferase
?
-
i.e. EC 2.1.1.14, gene locus At517920
-
-
?
N6-PhEt-ATP-gamma-S + aldehyde dehydrogenase 7B4
?
-
gene locus At1g54100
-
-
?
N6-PhEt-ATP-gamma-S + aquaporin interactor
?
-
gene locus At4g38220
-
-
?
N6-PhEt-ATP-gamma-S + beta glucosidase 18
?
-
gene locus At1g52400
-
-
?
N6-PhEt-ATP-gamma-S + fructose-bisphosphate aldolase 2
?
-
gene locus At4g38970
-
-
?
N6-PhEt-ATP-gamma-S + glyceraldehyde-3-phosphate dehydrogenase C2
?
-
gene locus At1g13440
-
-
?
N6-PhEt-ATP-gamma-S + heat shock protein 70
?
-
gene locus At3g09440
-
-
?
N6-PhEt-ATP-gamma-S + isopropylmalate dehydrogenase 1
?
-
gene locus At5g14200
-
-
?
N6-PhEt-ATP-gamma-S + low expression of osmotically responsive genes 2
?
-
gene locus At2g36530
-
-
?
N6-PhEt-ATP-gamma-S + mitochondrial malate dehydrogenase 1
?
-
gene locus At1g53240
-
-
?
N6-PhEt-ATP-gamma-S + NAD(P)-binding Rossmann-fold superfamily protein
?
-
gene locus At5g19440
-
-
?
N6-PhEt-ATP-gamma-S + proline iminopeptidase
?
-
gene locus At2g14260
-
-
?
N6-PhEt-ATP-gamma-S + thioglucoside glucohydrolase 1
?
-
gene locus At5g26000
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
cdk2-cyclin A phosphorylates e.g. protein substrate p107 and peptide substrate PKTPKKAKKL, requiring a small hydrophobic patch RXL, known as a recruitment peptide
-
-
?
ATP + axonal cytoskeleton protein
ADP + phosphorylated axonal cytoskeleton protein
-
-
-
-
?
ATP + axonal cytoskeleton protein
ADP + phosphorylated axonal cytoskeleton protein
-
regulated by integrin alpha1beta1
-
-
?
ATP + bloom syndrome helicase
ADP + phosphorylated bloom syndrome helicase
-
-
-
-
?
ATP + bloom syndrome helicase
ADP + phosphorylated bloom syndrome helicase
-
phosphorylation at Ser-714 and Thr-766, both the N- and C-terminal domains are phosphorylated by Cdc2
-
-
?
ATP + BRCA2
ADP + phosphorylated BRCA2
-
phosphorylates at Ser3291, phosphorylation reaches maximal levels in G2/M
-
-
?
ATP + BRCA2
ADP + phosphorylated BRCA2
-
phosphorylates at Ser3291, an event that disrupts association with RAD51
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
-
-
-
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
-
Cdk7 phosphorylates Ser-5 in the heptad repeats of the C-terminal domain of RNA polymerase II, Cdk9 phosphorylates Ser-2 in the C-terminal domain of RNA RNA polymerase II
-
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
-
-
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
Cdk phosphorylation affects interaction of Cdc20 with Mad2 and the anaphase-promoting complex-cyclosome in HeLa cells
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
in vitro substrate of Cdk1 and Cdk2
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
substrate of Cdk1, rather than of Cdk2
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
in vitro substrate of Cdk1 and Cdk2
-
-
?
ATP + cdk2
ADP + phosphorylated cdk2
-
CDK7 phosphorylates the activation segment or T-loop of CDK2
-
-
?
ATP + Cln3 protein
ADP + Cln3 phosphoprotein
-
recombinant His-tagged Cln3 protein is phosphorylated by Pho85/Pho80 complexes at S449 and T520. Cdc28 phosphorylates Cln3 to a greater extent than Pho85, probably because it phosphorylates Cln3 at more sites in the PEST region than Pho85
-
-
?
ATP + Cln3 protein
ADP + Cln3 phosphoprotein
-
recombinant His-tagged Cln3 protein is phosphorylated by Pho85/Pho80 complexes at S449 and T520. Cdc28 phosphorylates Cln3 to a greater extent than Pho85, probably because it phosphorylates Cln3 at more sites in the PEST region than Pho85
-
-
?
ATP + dephosphin
ADP + phosphorylated dephosphin
-
Cdk5 regulates endocytosis involving dephosphin activity, overview
-
-
?
ATP + early mitotic inhibitor 1 protein
ADP + early mitotic inhibitor 1 phosphoprotein
-
-
-
-
?
ATP + early mitotic inhibitor 1 protein
ADP + early mitotic inhibitor 1 phosphoprotein
-
i.e. Emi1, is phosphorylated by CDKs in mitotic but not S-phase cell extracts
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB3
ADP + phosphorylated ErbB3
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + ErbB3
ADP + phosphorylated ErbB3
-
phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin
-
-
?
ATP + eukaryotic elongation factor 2
ADP + phosphorylated eukaryotic elongation factor 2
-
phosphorylation on Ser595 by Cdk2
-
-
?
ATP + eukaryotic elongation factor 2
ADP + phosphorylated eukaryotic elongation factor 2
-
phosphorylation on Ser595 by Cdk2. Substrate mutant S595A is poorly phosphorylated by cyclin A-CDK2
-
-
?
ATP + Fkh2p
ADP + phosphorylated Fkh2p
-
phosphorylation of forkhead transcription factor Fkh2p is part of regulation of cell cycle-specific gene expression, e.g. of the CLB2 cluster, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation, overview
-
-
?
ATP + Fkh2p
ADP + phosphorylated Fkh2p
-
forkhead transcription factor Fkh2p, C-terminally phosphorylation of Fkh2p promotes interaction with the activator Ndd1p, which becomes also phosphorylated, activity with Fkh2p mutants, overview
-
-
?
ATP + glucocorticoid receptor
ADP + phosphorylated glucocorticoid receptor
-
-
-
-
?
ATP + glucocorticoid receptor
ADP + phosphorylated glucocorticoid receptor
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
commercial substrate
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
substrate of CDK11p110
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of e.g. of cheimeric K-cyclin/cdk6 and K-cyclin-cyclin D2
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
preferred substrate of cdk5 associated with p35
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
commercial substrate, Cdk5
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of CDKB
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of Cdk-A/cyclin D2
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
substrate of Cdk-A/cyclin D2 and of proliferating cell nuclear antigen/cyclin D2
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
-
huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
-
huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201
-
-
?
ATP + MAP1B
ADP + phosphorylated MAP1B
-
reaction in growth cones is important for stability of microtubules
-
-
?
ATP + MAP1B
ADP + phosphorylated MAP1B
-
type 1 phosphorylation in the mab1E11 recognition site
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor
-
-
?
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor, purified recombinant PRMT5/MEP50 produced in Sf9 cells or HeLa cells, phosphorylation of Thr5 and perhaps Ser264 by CDK4
-
-
?
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
-
a PRMT5 co-regulatory factor
-
-
?
ATP + Munc-18
ADP + phosphorylated Munc-18
-
involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
-
phosphorylation at Ser1176 by Cdk5
-
-
?
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
-
phosphorylation at Ser1176 in the sequence RPKTLSPGKN by Cdk5
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 in the consensus sequence RSRSPR by Cdk5, Cdk5 associates with Erb3 in vivo
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 in the sequence AKTPIKWAL and Ser1120 in the consensus sequence RSRSPR by Cdk5, weak phosphorylation of Ser1204 in the proline-rich sequence RRGSPPRPPR
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 by Cdk5
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H peptide
ADP + phosphorylated NF-H peptide
-
i.e. RREAKSPAKAKSPAKE
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NR1 receptor
ADP + phosphorylated NR1 receptor
-
involved in synaptic transmission, overview
-
-
?
ATP + NR2 receptor
ADP + phosphorylated NR2 receptor
-
involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview
-
-
?
ATP + NR2 receptor
ADP + phosphorylated NR2 receptor
-
with phosphorylation sites on both, A and B subunits, e.g. Ser1232 on the A subunit
-
-
?
ATP + parkin
ADP + phosphorylated parkin
-
Ser-131 located at the linker region of parkin is the major Cdk5 phosphorylation site, phosphorylation by Cdk5 decreases the auto-ubiquitylation of parkin, parkin S131A mutant has 40% lower phosphorylation levels in vivo than wild-type parkin
-
-
?
ATP + parkin
ADP + phosphorylated parkin
-
Ser-131 located at the linker region of parkin is the major Cdk5 phosphorylation site, phosphorylation by Cdk5 decreases the auto-ubiquitylation of parkin
-
-
?
ATP + parkin
ADP + phosphorylated parkin
-
parkin has four putative Cdk5 phosphorylation sites according to the motif (S/T)PX(K/R)
-
-
?
ATP + PKTPKKAKKL
ADP + PKpTPKKAKKL
-
GST-tagged recombinant peptide substrate
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
cyclin-dependent kinase activity is required for progesterone receptor PR function, the phosphorylation of the receptor protein has little effect, but cyclin A/Cdk2 acts as a progesterone receptor coactivator via stimulation of PR transcription, Cdk2-cyclin A is PR-dependently recruited to the PR promoter binding to cyclin A, mechanism involving SCR-1 and regulation, overview
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
Cdk2-cyclin A
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
-
cyclin A2/Cdk2 phosphorylates progesterone receptor in vitro at Ser25, Ser162, Ser190, Ser213, Ser400, Thr 430, Ser554 and Ser676
-
-
?
ATP + protein
ADP + phosphoprotein
-
NIMA is a cell cycle regulated protein kinase required, in addition to p34cdc2/cyclin B, for initiation of mitosis. NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis. NIMA degradation during mitosis is required for correct mitotic progression in Aspergillus nidulans
-
-
?
ATP + protein
ADP + phosphoprotein
the enzyme is likely to be involved in regulating the cell cycle and therefore may have a role in oncogenesis
-
-
-
ATP + protein
ADP + phosphoprotein
serine/threonine-specific protein kinase
-
-
-
ATP + protein
ADP + phosphoprotein
receptor protein tyrosine kinase
-
-
-
ATP + Rad9 protein
ADP + Rad9 phosphoprotein
-
a DNA damage response mediator
-
-
?
ATP + Rad9 protein
ADP + Rad9 phosphoprotein
-
a DNA damage response mediator, phosphorylaation at Thr125 and Thr143
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
-
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites in the cell cycle G1 phase
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, phosphorylation by CDK4/cyclin D
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, recombinant GST-tagged substrate, substrate of e.g. of chimeric K-cyclin/cdk6 and K-cyclin-cyclin D2
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
-
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
the phosphorylation site is at Ser795
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + retinoblastoma phosphoprotein
-
a tumor suppressor protein
-
-
?
ATP + retinoblastoma protein
ADP + retinoblastoma phosphoprotein
-
a tumor suppressor protein, phosphorylated by Cdk5-p25
-
-
?
ATP + retinoblastoma-related protein
ADP + phosphorylated retinoblastoma-related protein
-
i.e. RBR, substrate of Cdk-A/cyclin D2
-
-
?
ATP + retinoblastoma-related protein
ADP + phosphorylated retinoblastoma-related protein
-
i.e. RBR, substrate of Cdk-A/cyclin D2 and of proliferating cell nuclear antigen/cyclin D2
-
-
?
ATP + RhoGEF Tus1p
ADP + phosphorylated RhoGEF Tus1p
-
-
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
phosphorylate the C-terminal domain of RNA polymerase II
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
-
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
CDK9 phosphorylates the carboxy-terminal domain of the largest subunit (RPB1) of RNA polymerase II
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
-
CDK7 and CDK8 phosphorylate the C-terminal domain of RNA Pol II
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphorylated RNA polymerase II C-terminal domain
-
phosphorylation by Cdk7 and Cdk9, phosphorylation at serine residues 2 and 5
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphorylated RNA polymerase II C-terminal domain
-
reccombinant GST-tagged substrate
-
-
?
ATP + SCR-1
ADP + phosphorylated SCR-1
-
Cdk2-cyclin A, phosphorylation at Lys5 regulates SCR-1 interaction with the progesterone receptor
-
-
?
ATP + SCR-1
ADP + phosphorylated SCR-1
-
Cdk2-cyclin A, phosphorylation at Lys5
-
-
?
ATP + septine 5
ADP + phosphorylated septine 5
-
Ser327 is the major phosphorylation site for Cdk5 in presence of activator p35
-
-
?
ATP + septine 5
ADP + phosphorylated septine 5
-
Ser327 is the major phosphorylation site for Cdk5 in presence of activator p35
-
-
?
ATP + Sic1
ADP + phosphorylated Sic1
-
Glc8 function is dependent on phosphorylation at Thr-118, which is phosphorylated by Pho85 in conjunction with cyclins Pcl6 and Pcl7, and possibly Pcl8 and Pcl10
-
-
?
ATP + STAT3
ADP + phosphorylated STAT3