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Literature summary for 2.7.11.22 extracted from

  • Larochelle, S.; Merrick, K.A.; Terret, M.E.; Wohlbold, L.; Barboza, N.M.; Zhang, C.; Shokat, K.M.; Jallepalli, P.V.; Fisher, R.P.
    Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells (2007), Mol. Cell, 25, 839-850.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
cyclin A Cdk2/cyclin A complex formation is proportional to total cyclin A levels Homo sapiens

Application

Application Comment Organism
additional information S phase onset coincides with activation of Cdk2, whereas Cdk1 triggers mitosis, Cdk7 is the Cdk1 and 2-activating kinase in vivo Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
Cdk7as expressed in HCT116 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
F91G replacement of wild-type Cdk7 with a version sensitive to bulky ATP analogs in human cancer cells, designated Cdk7as Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-NMPP1 inhibits Cdk7, selective inhibition of Cdk7 in G1 prevents activation but not formation of Cdk2/cyclin complexes and delays S phase. Inhibiting Cdk7 in G2 blocks entry to mitosis and disrupts Cdk1/cyclin B complex assembly Homo sapiens
actinomycin D is less effective than 1-NMPP1 at inhibiting Cdk2 T loop phosphorylation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Cdk1 Homo sapiens Cdk7 ADP + phosphorylated Cdk2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Cdk1 Cdk7 Homo sapiens ADP + phosphorylated Cdk2
-
 ?

Synonyms

Synonyms Comment Organism
Cdk1/Cyclin B
-
 Homo sapiens
CDK2
-
 Homo sapiens
cdk7
-
 Homo sapiens