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Literature summary for 2.7.11.22 extracted from
- Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model? (2003), Biochemistry, 42, 601-607.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | phosphorylation regulates the enzyme activity, cyclin activating kinase CAK phosphorylates Thr160 of cdk2 leading to activation of cdk2 | eukaryota |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
eukaryota |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| eukaryota | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation regulates the enzyme activity, cyclin activating kinase CAK phosphorylates Thr160 of cdk2 leading to activation of cdk2, phosphorylation increases substrate binding of cdk2 by 2fold | eukaryota |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | activation involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated at a Thr residue, phosphorylation leads to enzyme inhibition | eukaryota |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
| ATP + cyclin dependent kinase 2 | cyclin activating kinase CAK phosphorylates Thr160 of cdk2, a prerequisite for cell cycle control | eukaryota | ADP + phosphorylated cyclin dependent kinase 2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CAK | - |
eukaryota |
| CDK2 | - |
eukaryota |
| cyclin activating kinase | - |
eukaryota |
| cyclin dependent kinase 2 | - |
eukaryota |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | the binding site is a deep pocket lined by hydrophobic residues, enzyme affinity of cdk2 for ATP is not influenced by phosphorylation of the activation loop | eukaryota | |
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