Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.17 extracted from

  • Gocher, A.; Azabdaftari, G.; Euscher, L.; Dai, S.; Karacosta, L.; Franke, T.; Edelman, A.
    Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells (2017), J. Biol. Chem., 292, 14188-14204 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calcium/calmodulin-dependent enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Akt Homo sapiens the enzyme (CaMKK2) directly phosphorylates Akt at Thr308 ADP + phosphorylated Akt
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96RR4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAOV-3 cell
-
 Homo sapiens
-
OVCAR-3 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt
-
 Homo sapiens ADP + phosphorylated Akt
-
 ?
ATP + Akt the enzyme (CaMKK2) directly phosphorylates Akt at Thr308 Homo sapiens ADP + phosphorylated Akt
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase kinase 2
-
 Homo sapiens
CaMKK2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens highly expressed in high-grade serous ovarian cancer up

General Information

General Information Comment Organism
malfunction knockdown or pharmacological inhibition of CaMKK2 produces phenotypes expected of Akt inhibition, including reductions in cell growth and cell viability and in the regulation of Akt downstream targets involved in G1/S transition and apoptosis. CaMKK2 knockdown or inhibition decreases Akt phosphorylation at Thr308 and Ser473 Homo sapiens
physiological function the enzyme (CaMKK2) regulates the growth and viability of OVCa cells Homo sapiens