Information on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.11.17
-
RECOMMENDED NAME
GeneOntology No.
Ca2+/calmodulin-dependent protein kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
141467-21-2
-
93229-57-3
-
97350-82-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
marine mollusk
-
-
Manually annotated by BRENDA team
isozyme CPK-1
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
a moss
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
cv. Jemalong A17
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
C57/Bl mice
SwissProt
Manually annotated by BRENDA team
CaMK1
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene CpkA; i.e. Phaeosphaeria nodorum or Septoria nodorum, wheat phytopathogenic fungus, three enzyme encoding genes CpkA, CpkB, and CpkC
SwissProt
Manually annotated by BRENDA team
strain Ng-1
SwissProt
Manually annotated by BRENDA team
strain Ng-1
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 40S-ribosomal protein S6
?
show the reaction diagram
-
rat brain
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + actin
ADP + phosphoactin
show the reaction diagram
-
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
show the reaction diagram
ATP + alpha-subunit of the cardiac Na+ channel NaV1.5-GST fusion peptide
ADP + phosphorylated alpha-subunit of the cardiac Na+ channel NaV1.5-GST fusion peptide
show the reaction diagram
-
phosphorylated in vitro by CaMKII predominantly on the I-II linker
-
-
?
ATP + autocamtide-2
ADP + phosphorylated autocamtide-2
show the reaction diagram
ATP + Bcl10
ADP + phosphorylated Bcl10
show the reaction diagram
-
phosphorylation by CaMKII at Ser138, recombinant FLAG-tagged Bcl10 substrate expressed in HEK-293T cells
-
-
?
ATP + beta-Pak-interacting exchange factor
ADP + phosphorylated beta-Pak-interacting exchange factor
show the reaction diagram
-
beta-Pak-interacting exchange factor is phosphorylated at Ser156
-
-
?
ATP + biotinylated Thr-Arg-Ser-Ala-Ile-Arg-Arg-Ala-Ser-Thr-Ile-Glu-Met-Pro-Gln-Gln-Ala-Arg-Gln
ADP + biotinylated Thr-Arg-Ser-Ala-Ile-Arg-Arg-Ala-Ser-phospho-Thr-Ile-Glu-Met-Pro-Gln-Gln-Ala-Arg-Gln
show the reaction diagram
-
biotinylated phospholamban Thr17 peptide substrate
-
-
?
ATP + Blc10
ADP + phosphorylated Blc10
show the reaction diagram
ATP + bovine serum albumin
ADP + phosphorylated bovine serum albumin
show the reaction diagram
-
low activity
-
-
?
ATP + Ca2+/calmodulin-dependent protein kinase I
ADP + phosphorylated Ca2+/calmodulin-dependent protein kinase I
show the reaction diagram
ATP + Ca2+/calmodulin-dependent protein kinase IV
ADP + phosphorylated Ca2+/calmodulin-dependent protein kinase IV
show the reaction diagram
ATP + Cabin1
ADP + phosphorylated Cabin1
show the reaction diagram
ATP + caldesmon
ADP + caldesmon phosphate
show the reaction diagram
ATP + cAMP response element binding protein
ADP + phosphorylated cAMP response element binding protein
show the reaction diagram
-
-
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
show the reaction diagram
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
ATP + cAMP-response element-binding protein
ADP + phosphorylated cAMP-response element-binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation at S133, substrate of CaMKIV and CaMKII
-
-
?
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
show the reaction diagram
ATP + CARMA1
ADP + phosphorylated CARMA1
show the reaction diagram
ATP + casein
?
show the reaction diagram
-
rat brain
-
-
-
ATP + casein
ADP + phosphocasein
show the reaction diagram
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
ATP + cyclic AMP response element binding protein
ADP + phosphorylated cyclic AMP response element binding protein
show the reaction diagram
-
phosphorylated at Ser133
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
show the reaction diagram
ATP + Emi2
ADP + phosphorylated Emi2
show the reaction diagram
-
an APC/C repressor, inactivation
-
-
?
ATP + estrogen-receptor from calf uterus
?
show the reaction diagram
-
-
-
-
-
ATP + eukaryotic translation initiation factor 4B
ADP + phosphorylated eukaryotic translation initiation factor 4B
show the reaction diagram
-
-
-
?
ATP + GABA A receptor
ADP + phosphorylated GABA A receptor
show the reaction diagram
-
-
-
-
?
ATP + GABA-modulin
?
show the reaction diagram
-
-
-
-
-
ATP + glutamate receptor subunit GluR1
ADP + phosphorylated glutamate receptor subunit GluR1
show the reaction diagram
ATP + glutamate receptor subunit NR2B
ADP + phosphorylated glutamate receptor subunit NR2B
show the reaction diagram
ATP + glycogen synthase
?
show the reaction diagram
-
rat brain
-
-
-
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
-
-
-
-
?
ATP + glycosylated phosducin-like protein
ADP + glycosylated phosducin-like phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + group I metabotropic glutamate receptor
ADP + phosphorylated group I metabotropic glutamate receptor
show the reaction diagram
-
CaMKIV contributes to the upregulation of fragile X mental retardation protein induced by stimulating group I metabotropic glutamate receptors
-
-
?
ATP + histone
?
show the reaction diagram
ATP + histone
ADP + phosphohistone
show the reaction diagram
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
show the reaction diagram
ATP + histone deacetylase 5
ADP + phosphorylated histone deacetylase 5
show the reaction diagram
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
rat CaMKIV prefers histone H1 over myelin basic protein, while Danio rerio CaMKIV does not
-
-
?
ATP + histone IIA
ADP + phosphorylated histone IIA
show the reaction diagram
-
-
-
-
?
ATP + histone IIIS
ADP + phosphorylated histone IIIS
show the reaction diagram
ATP + histone IIS
ADP + phosphorylated histone IIS
show the reaction diagram
-
-
-
-
?
ATP + histone VI
ADP + phosphorylated histone VI
show the reaction diagram
-
-
-
-
?
ATP + histone VIIS
ADP + phosphorylated histone VIIS
show the reaction diagram
-
-
-
-
?
ATP + histone VIS
ADP + phosphorylated histone VIS
show the reaction diagram
-
-
-
-
?
ATP + histone VS
ADP + phosphorylated histone VS
show the reaction diagram
-
-
-
-
?
ATP + Homer3 protein
ADP + Homer3 phosphoprotein
show the reaction diagram
-
Homer3 protein is phosphorylated at Ser120, Ser159, and Ser176 by CaMKII
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosporylated human cardiac sodium channel NaV1.5
show the reaction diagram
ATP + I-kappaB
ADP + phosphorylated I-kappaB
show the reaction diagram
ATP + Kemptide
ADP + LRRAS(P)LG
show the reaction diagram
-
i.e. LRRASLG, low activity
-
-
?
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
show the reaction diagram
ATP + KKALRRQETVDAL
ADP + KKALRRQET(P)VDAL
show the reaction diagram
-
i.e. autocamtide-2
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
show the reaction diagram
ATP + MAP2
ADP + phosphorylated MAP2
show the reaction diagram
-
-
-
-
?
ATP + MEF-2A
ADP + phosphorylated MEF-2A
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2C
ADP + phosphorylated MEF-2C
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2D
ADP + phosphorylated MEF-2D
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
show the reaction diagram
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
show the reaction diagram
ATP + microtubule-associated protein tau
?
show the reaction diagram
ATP + myelin basic protein
?
show the reaction diagram
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
rat CaMKIV prefers histone H1 over myelin basic protein, while Danio rerio CaMKIV does not
-
-
?
ATP + myosin
ADP + phosphomyosin
show the reaction diagram
ATP + myosin II light chain
ADP + phosphorylated myosin II light chain
show the reaction diagram
ATP + myosin light chain
?
show the reaction diagram
ATP + Na+-channel
ADP + phosphorylated Na+-channel
show the reaction diagram
ATP + NADPH oxidase 5
ADP + phosphoraletd NADPH oxidase 5
show the reaction diagram
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
show the reaction diagram
ATP + NFkappaB
ADP + phosphorylated NFkappaB
show the reaction diagram
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
ATP + NHE-1
ADP + phosphorylated NHE-1
show the reaction diagram
ATP + NMDA receptor
ADP + phosphorylated NMDA receptor
show the reaction diagram
-
-
-
-
?
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
show the reaction diagram
ATP + PC12 pheochromacytoma cell line protein substrate pp250
?
show the reaction diagram
-
-
-
-
-
ATP + peptide AC2
ADP + phosphorylated peptides AC2
show the reaction diagram
-
Ca2+-independent autonomous activity after Thr286 autophosphorylation is65% of maximal stimulated activity
-
-
?
ATP + phosphatidylinositol 3-kinase
ADP + phosphorylated phosphatidylinositol 3-kinase
show the reaction diagram
-
-
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
show the reaction diagram
ATP + phosvitin
ADP + phosphorylated phosvitin
show the reaction diagram
-
-
-
-
?
ATP + PLB
ADP + phosphorylated PLB
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + PLN
ADP + phosphorylated PLN
show the reaction diagram
ATP + PLRRTLSVAA
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + PLRRTLSVAA-amide
ADP + phosphorylated PLRRTLSVAA-amide
show the reaction diagram
-
glycogen synthase-derived peptide GSP
-
-
?
ATP + protamin
ADP + phosphorylated protamin
show the reaction diagram
-
low activity
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein CREB
ADP + phosphorylated protein CREB
show the reaction diagram
ATP + protein ERK
ADP + phosphorylated protein ERK
show the reaction diagram
activation by phosphorylation
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
show the reaction diagram
ATP + protein kinase B
ADP + phosphorylated protein kinase B
show the reaction diagram
-
-
-
-
?
ATP + protein kinase G
ADP + phosphorylated protein kinase G
show the reaction diagram
-
-
-
?
ATP + protein PLB
ADP + phosphorylated protein PLB
show the reaction diagram
ATP + protein PLN
ADP + phosphorylated Pprotein LN
show the reaction diagram
-
PLN regulation through phosphorylation by CaMKII at Thr17
-
-
?
ATP + protein PLN
ADP + phosphorylated protein PLN
show the reaction diagram
-
a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17
-
-
?
ATP + protein RyR
ADP + phosphorylated protein RyR
show the reaction diagram
ATP + PSD-95
ADP + phosphorylated PSD-95
show the reaction diagram
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
show the reaction diagram
ATP + ryanodine receptor type 2
ADP + phosphorylated ryanodine receptor type 2
show the reaction diagram
ATP + RyR
ADP + phosphorylated RyR
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + S6-kinase
?
show the reaction diagram
-
step of a protein kinase cascade initiated by insulin in a yet unidentified manner
-
-
-
ATP + S6-kinase II
?
show the reaction diagram
ATP + Stargazin
ADP + phosphorylated Stargazin
show the reaction diagram
ATP + STAT3
ADP + phosphorylated STAT3
show the reaction diagram
-
-
-
?
ATP + stress-induced phosphoprotein 1
ADP + phosphorylated stress-induced phosphoprotein 1
show the reaction diagram
phosphorylated on Ser198
-
-
?
ATP + synapsin
?
show the reaction diagram
-
rat brain
-
-
-
ATP + synapsin
ADP + phosphorylated synapsin
show the reaction diagram
-
-
-
-
?
ATP + synapsin
ADP + phosphosynapsin
show the reaction diagram
ATP + synapsin I
ADP + phosphorylated synapsin I
show the reaction diagram
ATP + synapsin I
ADP + phosphosynapsin I
show the reaction diagram
-
-
-
-
?
ATP + synapsin II
ADP + phosphorylated synapsin II
show the reaction diagram
ATP + synapsin-1
ADP + phopshorylated synapsin-1
show the reaction diagram
-
-
-
-
?
ATP + synGAP
ADP + phosphorylated synGAP
show the reaction diagram
ATP + synthide-2
ADP + phorphorylated synthide-2
show the reaction diagram
-
-
-
?
ATP + syntide-2
ADP + phosphorylated syntide-2
show the reaction diagram
ATP + syntide2
ADP + phosphorylated syntide2
show the reaction diagram
-
Ca2+-independent autonomous activity after Thr286 autophosphorylation is25% of maximal stimulated activity
-
-
?
ATP + tau peptide 408-420
ADP + phosphorylated tau peptide 408-420
show the reaction diagram
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
ATP + tropomyosin
ADP + phosphotropomyosin
show the reaction diagram
-
-
-
-
?
ATP + tubulin
?
show the reaction diagram
ATP + type alpha cytosolic phospholipase A2
ADP + phosphorylated type alpha cytosolic phospholipase A2
show the reaction diagram
-
CaMK regulates the type alpha cytosolic phospholipase A2 via phosphorylation at Ser515
-
-
?
ATP + vimentin
?
show the reaction diagram
-
rat brain
-
-
-
ATP + vimentin
ADP + phosphorylated vimentin
show the reaction diagram
ATP + voltage-gated calcium channel beta1b subunit
ADP + phosphorylated voltage-gated calcium channel beta1b subunit
show the reaction diagram
-
-
-
-
?
ATP + voltage-gated calcium channel beta2a subunit
ADP + phosphorylated voltage-gated calcium channel beta2a subunit
show the reaction diagram
-
CaMKII phosphorylates at Thr498
-
-
?
ATP + voltage-gated calcium channel beta3 subunit
ADP + phosphorylated voltage-gated calcium channel beta3 subunit
show the reaction diagram
-
-
-
-
?
ATP + voltage-gated calcium channel beta4 subunit
ADP + phosphorylated voltage-gated calcium channel beta4 subunit
show the reaction diagram
-
-
-
-
?
ATP + YLRRRLSDSNF
ADP + ?
show the reaction diagram
synapsin site I-derived peptide substrate
-
-
?
additional information
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + Blc10
ADP + phosphorylated Blc10
show the reaction diagram
-
Bcl10 is essential for antigen receptor-induced NF-kappaB activation, interleukin-2 production, and T-cell proliferation but is not required for TCR-induced tyrosine phosphorylation, calcium flux, or extracellular signal-regulated kinase activation
-
-
?
ATP + Ca2+/calmodulin-dependent protein kinase I
ADP + phosphorylated Ca2+/calmodulin-dependent protein kinase I
show the reaction diagram
Q96RR4
the enzyme is a member of the CaMK cascade that mediates the response to intracellular Ca2+ elevation. Ca2+/calmodulin-dependent protein kinase kinase phosphorylates and activates Ca2+/calmodulin-dependent protein kinase I and Ca2+/calmodulin-dependent protein kinase IV, which directly activate transcription factors
-
-
?
ATP + Ca2+/calmodulin-dependent protein kinase IV
ADP + phosphorylated Ca2+/calmodulin-dependent protein kinase IV
show the reaction diagram
Q96RR4
the enzyme is a member of the CaMK cascade that mediates the response to intracellular Ca2+ elevation. Ca2+/calmodulin-dependent protein kinase kinase phosphorylates and activates Ca2+/calmodulin-dependent protein kinase I and Ca2+/calmodulin-dependent protein kinase IV, which directly activate transcription factors
-
-
?
ATP + Cabin1
ADP + phosphorylated Cabin1
show the reaction diagram
-
a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, CaMKIV regulates nuclear export of Cabin1 during Ca2+-dependent T-cell activation, regulation overview
-
-
?
ATP + caldesmon
ADP + caldesmon phosphate
show the reaction diagram
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
show the reaction diagram
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
show the reaction diagram
-
i.e. CREB, CaM kinase II, as part of the Ca2+ and CaMK signaling cascade, regulates the phosphorylation of CREB of spinal cord in rats following noxious stimulation, e.g. by capsaicin injection
-
-
?
ATP + CARMA1
ADP + phosphorylated CARMA1
show the reaction diagram
-
CaMKII is a modulator of CARMA1-mediated NF-kappaB activation, overview
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
show the reaction diagram
-
the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization
-
-
?
ATP + Emi2
ADP + phosphorylated Emi2
show the reaction diagram
-
an APC/C repressor, inactivation
-
-
?
ATP + glutamate receptor subunit GluR1
ADP + phosphorylated glutamate receptor subunit GluR1
show the reaction diagram
-
low activity, CaMKII, membrane localization of GluR1 restricts its phosphorylation
-
-
?
ATP + glutamate receptor subunit NR2B
ADP + phosphorylated glutamate receptor subunit NR2B
show the reaction diagram
-
low activity, CaMKII
-
-
?
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
show the reaction diagram
-
the enzyme may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosporylated human cardiac sodium channel NaV1.5
show the reaction diagram
-
the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites. The phosphorylation status of Ser516 and Thr594 on cardiac sodium channel NaV1.5, is an important mediator of the enzyme-dependent negative shift in cardiac sodium channel NaV1.5
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
show the reaction diagram
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
show the reaction diagram
-
phosphorylation of Kir6.2 subunit of cardiac ATP-sensitive potassium channel promotes endocytosis of cardiac ATP-sensitive potassium channels
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
show the reaction diagram
ATP + MAP2
ADP + phosphorylated MAP2
show the reaction diagram
-
-
-
-
?
ATP + MEF-2A
ADP + phosphorylated MEF-2A
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2C
ADP + phosphorylated MEF-2C
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2D
ADP + phosphorylated MEF-2D
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
show the reaction diagram
-
CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension
-
-
?
ATP + Na+-channel
ADP + phosphorylated Na+-channel
show the reaction diagram
-
isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview
-
-
?
ATP + NADPH oxidase 5
ADP + phosphoraletd NADPH oxidase 5
show the reaction diagram
-
the enzyme mediates the phosphorylation and activation of NADPH oxidase 5. The ability of Ca2+/calmodulin-dependent protein kinase to regulate NADPH oxidase 5 activity may be significant in the regulation of production of reactive oxygen species that occurs downstream of calcium-mobilizing agonists such as angiotensin II. Of these phosphorylation sites, mutation of only Ser475 to alanine prevents Ca2+/calmodulin-dependent protein kinase-induced increases in activity of NADPH oxidase 5
-
-
?
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
show the reaction diagram
-
phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV
-
-
?
ATP + NFkappaB
ADP + phosphorylated NFkappaB
show the reaction diagram
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
ATP + NHE-1
ADP + phosphorylated NHE-1
show the reaction diagram
-
phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger
-
-
?
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
show the reaction diagram
-
phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
show the reaction diagram
ATP + PLB
ADP + phosphorylated PLB
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + PLN
ADP + phosphorylated PLN
show the reaction diagram
-
phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
show the reaction diagram
ATP + protein ERK
ADP + phosphorylated protein ERK
show the reaction diagram
Q923T9
activation by phosphorylation
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
show the reaction diagram
-
phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm
-
-
?
ATP + protein PLB
ADP + phosphorylated protein PLB
show the reaction diagram
ATP + protein PLN
ADP + phosphorylated Pprotein LN
show the reaction diagram
-
PLN regulation through phosphorylation by CaMKII at Thr17
-
-
?
ATP + protein RyR
ADP + phosphorylated protein RyR
show the reaction diagram
ATP + PSD-95
ADP + phosphorylated PSD-95
show the reaction diagram
-
high activity, CaMKII, smaller synapses show greater variability in PSD-95 phosphorylation
-
-
?
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
show the reaction diagram
-
the enzyme phosphorylates Raf-1 at Ser338 and mediates Ras-stimulated Raf-1 activation
-
-
?
ATP + ryanodine receptor type 2
ADP + phosphorylated ryanodine receptor type 2
show the reaction diagram
-
i.e. RyR2
-
-
?
ATP + RyR
ADP + phosphorylated RyR
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + S6-kinase
?
show the reaction diagram
-
step of a protein kinase cascade initiated by insulin in a yet unidentified manner
-
-
-
ATP + Stargazin
ADP + phosphorylated Stargazin
show the reaction diagram
-
high activity, CaMKII, phosphatases limit phosphorylation of stargazin
-
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?
ATP + synapsin
ADP + phosphorylated synapsin
show the reaction diagram
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?
ATP + synapsin-1
ADP + phopshorylated synapsin-1
show the reaction diagram
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?
ATP + synGAP
ADP + phosphorylated synGAP
show the reaction diagram
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regulation and activation of the neuron-specific Ras GTPase-activating protein, synGAP, by phosphorylation through CaMKII in the postsynaptic density fraction of the forebrain, synGAP is part of the signaling complex attached to the cytoplasmic tail of the N-methyl-D-aspartate-type glutamate receptor, overview
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ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
ATP + vimentin
ADP + phosphorylated vimentin
show the reaction diagram
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specific phosphorylation by CaMKII at Ser82
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additional information
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