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Literature summary for 2.7.11.17 extracted from
- Basic calcium phosphate crystals induce osteoarthritis-associated changes in phenotype markers in primary human chondrocytes by a calcium/calmodulin kinase 2-dependent mechanism (2019), Calcif. Tissue Int., 104, 331-343 .
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| chondrocyte | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calcium/calmodulin-dependent protein kinase 2 | - |
Homo sapiens |
| CaMK2 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | intracellular levels of phosphorylated and total calcium/calmodulin kinase 2 are elevated following basic calcium phosphate treatment | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | calcium/calmodulin-dependent protein kinase 2 inhibition or knockdown ameliorates the basic calcium phosphate-induced changes in sry-box 9, indian hedgehog, type X collagen, interleukin-6 and matrix metalloproteinase 13 expression | Homo sapiens |
| physiological function | enzyme activity contributes to basic calcium phosphate crystal-induced changes in chondrocyte phenotypic marker expression | Homo sapiens |
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Release 2023.1 (January 2023)
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