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Literature summary for 2.7.11.17 extracted from

  • Schuh, K.; Uldrijan, S.; Gambaryan, S.; Roethlein, N.; Neyses, L.
    Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK (2003), J. Biol. Chem., 278, 9778-9783.
    View publication on PubMed
Search for more literature for 2.7.11.17

Inhibitors

Inhibitors Comment Organism Structure
PMCA4b wild-type PMCA4b inhibits CASK activity, while PMCA4b mutant D672E, containing a point mutation in the ATP binding site, shows only 10% of the wild-type inhibitory potency Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CASK in inhibited by the plasma membrane Ca2+ pump 4b/CI, PMCA4b, via direct interaction with the C-terminus of the Ca2+ transporter ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver high activity Rattus norvegicus
-
lung low activity Rattus norvegicus
-
spleen very low activity Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CASK in inhibited by the plasma membrane Ca2+ pump 4b/CI, PMCA4b, via direct interaction with the C-terminus of the Ca2+ transporter Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent membrane-associated kinase
-
 Rattus norvegicus
CASK
-
 Rattus norvegicus
More the enzyme is a member of the MAGUK family Rattus norvegicus