Activating Compound | Comment | Organism | Structure |
---|---|---|---|
prolactin | activates Jak2 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant JAK2 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K882E | kinase-inactive JAK2 mutant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + PAK1 | Homo sapiens | Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1 | ADP + phospho-L-tyrosinyl-PAK1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + PAK1 | Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1 | Homo sapiens | ADP + phospho-L-tyrosinyl-PAK1 | - |
? | |
ATP + PAK1 | a serine-threonine kinase, phosphorylation at Y153, Y201, and Y285 activates PAK1, no activation of PAK1 mutants Y153F,Y201F,Y285F, mutational analysis of phosphorylation sites,overview | Homo sapiens | ADP + phospho-L-tyrosinyl-PAK1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JAK2 | - |
Homo sapiens |
JAK2 tyrosine kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |