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70 kDa zeta-associated protein
-
-
-
A-Raf proto-oncogene serine/threonine-protein kinase
Abelson murine leukemia viral homolog (1) protein
Abelson tyrosine kinase
-
-
Abl nonreceptor tyrosine kinase
-
-
Abl protein tyrosine kinase
ABL2/ARG tyrosine kinase
-
-
activated Cdc42-associated tyrosine kinase 1
-
activin receptor type IIA
-
activin receptor type IIB
Agammaglobulinaemia tyrosine kinase
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
anti-mullerian hormone type II receptor
B lymphocyte kinase
-
-
-
B-cell/myeloid kinase
-
-
-
B-Raf proto-oncogene serine/threonine-protein kinase
-
BMP-2/BMP-4 receptor
-
-
-
Bone marrow kinase BMX
-
-
-
bone morphogenetic protein receptor type IA
bone morphogenetic protein receptor type IB
bone morphogenetic protein receptor type II
-
Bruton's tyrosine kinase PH domain
-
Bruton’s tyrosine kinase
-
-
c-Fes protein-tyrosine kinase
-
-
c-Fes tyrosine kinase
-
-
c-Src nonreceptor tyrosine kinase
-
-
c-Src protein tyrosine kinase
-
-
Calcium-dependent tyrosine kinase
-
-
-
calcium-dependent tyrosine kinase PYK2
-
-
CARD-containing interleukin-1 beta converting enzyme associated kinase
-
Cell adhesion kinase beta
-
-
-
cell-surface receptor daf-1
-
cell-surface receptor daf-4
-
cellular form of the transforming agent of Rous sarcoma virus
-
-
Csk homologous kinase
-
-
Csk protein-tyrosine kinase
-
-
CSK-homologous kinase
-
-
cytoplasmic protein tyrosine kinase
-
-
cytoplasmic tyrosine-protein kinase BMX
-
Epithelial and endothelial tyrosine kinase
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
Fer protein-tyrosine kinase
-
-
focal adhesion kinase 1
-
-
-
focal adhesion protein tyrosine
Fps/Fes protein-tyrosine kinase
-
-
Fps/Fes tyrosine kinase
-
-
gene lck protein kinase
-
-
-
gene lck tyrosine kinase
-
-
-
hck-tr
truncated form of the src-related tyrosine kinase hck
Hematopoietic consensus tyrosine-lacking kinase
Hemopoietic cell kinase
-
-
-
IL-1R-associated kinase
-
IL-2-inducible T-cell kinase
-
-
-
integrin-linked protein kinase
-
integrin-linked protein kinase 1
-
integrin-linked protein kinase 76
-
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase-81
-
JAK protein tyrosine kinase
-
-
-
JAK2 protein tyrosine kinase
-
Janus family kinase JAK3
-
just another kinase 2
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
Lck Tyrosine kinase
-
-
-
lymphocyte-specific protein tyrosine kinase
Lyn protein tyrosine kinase
-
-
megakaryocyte-associated tyrosine-protein kinase
mullerian inhibiting substance type II receptor
-
neuronal proto-oncogene tyrosine-protein kinase SRC
-
non-receptor membrane-associated PTK
-
-
non-receptor protein tyrosine kinase
non-receptor protein-tyrosine kinase
-
-
non-receptor tyrosine kinase
non-receptor tyrosine kinase brk
-
non-receptor tyrosine-protein kinase TYK2
nonreceptor protein tyrosine kinase
-
-
-
nonreceptor tyrosine kinase
nonreceptor tyrosine kinase Fes
-
nonreceptor tyrosine kinase Src
-
nonreceptor tyrosine kinase Srm
-
Nuclear tyrosine protein kinase RAK
-
-
-
p135tyk2 tyrosine kinase
-
p56lck protein kinase
-
-
-
p56lck protein tyrosine kinase
-
-
-
p56lck tyrosine kinase
-
-
-
phosphotyrosyl-protein kinase
-
-
-
proline-rich tyrosin ekinase 2
-
-
proline-rich tyrosine kinase 2
proline-rich tyrosine kinase-2
-
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
Protein kinase BATK
-
-
-
Protein kinase p56-LCK
-
-
-
Protein kinase p56lck
-
-
-
Protein p56c-lck kinase
-
-
-
Protein p56lck tyrosine kinase
-
-
-
protein tyrosine kinase 2
-
-
protein tyrosine kinase 2beta
-
-
-
protein tyrosine kinase 6
-
protein tyrosine kinase focal adhesion kinase
-
-
Protein tyrosine kinase lck
-
-
-
Protein tyrosine kinase p56lck
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
protein tyrosine kinase PTK70
-
protein-tyrosine kinase Brk
-
Protein-tyrosine kinase C-TKL
-
-
-
Protein-tyrosine kinase CYL
-
-
-
Protein-tyrosine kinase Syk
-
-
proto-oncogene serine/threonine-protein kinase mos
proto-oncogene tyrosine-protein kinase ABL1
proto-oncogene tyrosine-protein kinase FER
-
proto-oncogene tyrosine-protein kinase FES/FPS
proto-oncogene tyrosine-protein kinase FGR
-
proto-oncogene tyrosine-protein kinase FYN
proto-oncogene tyrosine-protein kinase LCK
proto-oncogene tyrosine-protein kinase SRC
proto-oncogene tyrosine-protein kinase YES
proto-oncogene tyrosine-protein kinase YRK
-
RAF homolog serine/threonine-protein kinase dRAF-1
-
RAF proto-oncogene serine/threonine-protein kinase
receptor interacting protein 3
receptor protein kinase CLAVATA1 precursor
-
receptor-associated kinase JAK2
-
receptor-interacting serine/threonine protein kinase 2
receptor-interacting serine/threonine protein kinase 3
-
receptor-like protein kinase 5 precursor
-
Related adhesion focal tyrosine kinase
-
-
-
Resting lymphocyte kinase
S-domain receptor-like protein kinase
-
-
-
serine/threonine kinase receptor
-
serine/threonine protein kinase mos
-
serine/threonine-protein kinase receptor R2
serine/threonine-protein kinase receptor R3
serine/threonine-protein kinase receptor TKV
-
serine/threonine-protein kinase sma-6
-
serine/threonine-protein kinase transforming protein mos
serine/threonine-protein kinase transforming protein raf
-
Src family tyrosine kinase Lyn
-
Src protein tyrosine kinase
-
-
src protein tyrosine kinase p56Lck
-
-
Src protein-tyrosine kinase
Src-family protein kinase
-
Src-family protein tyrosine kinase
-
-
SRC-related intestinal kinase
Syk-related tyrosine kinase
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
T-cell-specific kinase
-
-
-
Tec family tyrosine kinase
-
-
testis-specific protein kinase 1
testis-specific protein kinase 2
TGF-beta receptor type II
TGF-beta type II receptor
-
transforming agent of Fujinami sarcoma virus
-
-
transforming growth factor beta type II receptor
-
transforming growth factor-beta type I receptor 7
-
Tyrosine kinase ARG
-
-
-
tyrosine kinase c-Src
-
-
Tyrosine kinase lck
-
-
-
Tyrosine kinase p56lck
-
-
-
tyrosine kinase p60c-src
-
-
tyrosine kinase sf-Stk
-
-
Tyrosine phosphokinase
-
-
-
Tyrosine protein kinase
-
-
-
Tyrosine protein kinase p56lck
-
-
-
tyrosine-protein kinase 6
tyrosine-protein kinase Abl
-
tyrosine-protein kinase abl-1
-
tyrosine-protein kinase ABL2
-
tyrosine-protein kinase BLK
Tyrosine-protein kinase brk
-
-
-
tyrosine-protein kinase BTK
tyrosine-protein kinase CSK
Tyrosine-protein kinase CTK
-
-
-
tyrosine-protein kinase Fps85D
-
tyrosine-protein kinase FRK
-
tyrosine-protein kinase HCK
tyrosine-protein kinase hopscotch
-
tyrosine-protein kinase HTK16
-
tyrosine-protein kinase ITK/TSK
tyrosine-protein kinase JAK1
tyrosine-protein kinase JAK2
tyrosine-protein kinase JAK3
Tyrosine-protein kinase Lyk
-
-
-
tyrosine-protein kinase LYN
tyrosine-protein kinase PR2
-
tyrosine-protein kinase shark
-
tyrosine-protein kinase SPK-1
-
tyrosine-protein kinase SRC-1
-
tyrosine-protein kinase SRC-2
-
tyrosine-protein kinase Src42A
-
tyrosine-protein kinase Src64B
-
tyrosine-protein kinase SRK1
-
tyrosine-protein kinase SRK4
-
tyrosine-protein kinase SRM
-
tyrosine-protein kinase STK
-
tyrosine-protein kinase SYK
tyrosine-protein kinase Tec
tyrosine-protein kinase transforming protein ABL
tyrosine-protein kinase transforming protein FES
tyrosine-protein kinase transforming protein FGR
tyrosine-protein kinase transforming protein fms
tyrosine-protein kinase transforming protein FPS
tyrosine-protein kinase transforming protein ros
tyrosine-protein kinase transforming protein SEA
tyrosine-protein kinase transforming protein SRC
tyrosine-protein kinase transforming protein YES
tyrosine-protein kinase TXK
Tyrosine-protein kinase TYRO 10
-
-
-
tyrosine-protein kinase ZAP-70
Tyrosine-specific protein kinase
-
-
-
Tyrosylprotein kinase
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
A-Raf proto-oncogene serine/threonine-protein kinase

-
A-Raf proto-oncogene serine/threonine-protein kinase
-
A-Raf proto-oncogene serine/threonine-protein kinase
-
A-Raf proto-oncogene serine/threonine-protein kinase
-
Abelson murine leukemia viral homolog (1) protein

-
-
Abelson murine leukemia viral homolog (1) protein
-
-
Abl

-
-
Abl kinase

-
-
Abl protein tyrosine kinase

-
-
Abl protein tyrosine kinase
-
Abl tyrosine kinase

Abelson leukaemia virus
-
-
Abl tyrosine kinase
-
present in 95% of patients with chronic myelogenous leukemia, CML
ABL1

-
-
ABL2

-
-
ACK1

-
-
activin receptor type I

-
activin receptor type I
-
activin receptor type I
-
activin receptor type II

-
activin receptor type II
-
activin receptor type II
-
activin receptor type II
-
activin receptor type II
-
activin receptor type IIB

-
activin receptor type IIB
-
activin receptor type IIB
-
ACTR-IIB

-
-
-
AKT

-
-
anti-mullerian hormone type II receptor

-
anti-mullerian hormone type II receptor
-
B cell progenitor kinase

-
-
-
B cell progenitor kinase
-
BCR-ABL tyrosine kinase

-
-
-
BCR-ABL tyrosine kinase
-
-
BCR/ABL kinase

-
-
Blk

-
-
BMP type II receptor

-
-
-
Bmx

-
-
bone morphogenetic protein receptor type IA

-
bone morphogenetic protein receptor type IA
-
bone morphogenetic protein receptor type IB

-
bone morphogenetic protein receptor type IB
-
bone morphogenetic protein receptor type IB
-
Breast tumor kinase

-
-
-
Brk

-
-
Bruton tyrosine kinase

-
Bruton's tyrosine kinase

-
-
-
Bruton's tyrosine kinase
-
-
Bruton's tyrosine kinase
-
Bruton's tyrosine kinase
-
-
Bruton's tyrosine kinase
-
Brutons tyrosine kinase

-
-
Brutons tyrosine kinase
-
Brutons tyrosine kinase
-
-
Brutons tyrosine kinase
-
-
Btk

-
-
c-ABL

-
-
-
c-Abl tyrosine kinase

-
-
c-Abl tyrosine kinase
-
isoforms 1a and 1b
C-SRC

-
-
-
C-SRC kinase

-
-
-
c-Src tyrosine kinase

-
-
c-Src tyrosine kinase
-
-
C-terminal Src kinase

-
-
C-terminal Src kinase
-
-
C-YES

-
-
-
Csk

-
-
ETK

-
-
FAK

-
Fgr

-
-
focal adhesion kinase

-
focal adhesion protein tyrosine

-
-
focal adhesion protein tyrosine
-
-
FRK

-
-
Fyn

-
-
HCK

-
-
Hematopoietic consensus tyrosine-lacking kinase

-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
interleukin-1 receptor-associated kinase 1

-
interleukin-1 receptor-associated kinase 1
-
Itk

-
-
-
JAK

-
-
Jak1

-
-
JAK2

-
-
JAK2
-
-
661392, 672954, 674865, 702439, 703984, 703985, 704787, 705448, 705664, 705895, 705943, 705953, 706405, 706765, 706766, 723583, 738741
Jak3

-
-
Janus kinase

-
-
Janus kinase
-
-
662571, 701645, 703984, 703985, 704787, 705664, 705895, 705953, 706405, 706765, 706766
Janus kinase 1

-
-
Janus kinase 2

-
-
Lck

-
-
Leukocyte janus kinase

-
-
-
LIM domain kinase 2

-
lymphocyte-specific protein tyrosine kinase

-
-
lymphocyte-specific protein tyrosine kinase
-
-
Lyn

-
-
Lyn tyrosine kinase

-
megakaryocyte-associated tyrosine-protein kinase

-
megakaryocyte-associated tyrosine-protein kinase
-
non-receptor protein tyrosine kinase

-
-
non-receptor protein tyrosine kinase
-
-
non-receptor PTK

-
-
non-receptor tyrosine kinase

-
-
non-receptor tyrosine kinase
-
-
non-receptor tyrosine kinase
-
-
non-receptor tyrosine-protein kinase TYK2

-
non-receptor tyrosine-protein kinase TYK2
-
nonreceptor tyrosine kinase

-
-
nonreceptor tyrosine kinase
-
-
nonreceptor tyrosine kinase
-
-
p40mos

-
p56lck

-
-
PP125FAK

-
-
-
proline-rich tyrosine kinase 2

-
-
proline-rich tyrosine kinase 2
-
Protein tyrosine kinase

-
-
-
Protein tyrosine kinase
-
-
Protein tyrosine kinase
-
Protein tyrosine kinase
-
-
660970, 661180, 661392, 661396, 661457, 661461, 661487, 661540, 661548, 661749, 662556, 662838, 662858, 663021, 663196, 663291, 674767, 690302
Protein tyrosine kinase
-
Protein tyrosine kinase
-
-
Protein tyrosine kinase
-
-
Protein tyrosine kinase
-
-
Protein tyrosine kinase
-
-
Protein tyrosine kinase
-
-
protein-tyrosine kinase

-
-
protein-tyrosine kinase
-
-
protein-tyrosine kinase
-
-
proto-oncogene serine/threonine-protein kinase mos

-
proto-oncogene serine/threonine-protein kinase mos
-
proto-oncogene serine/threonine-protein kinase mos
-
proto-oncogene serine/threonine-protein kinase mos
-
proto-oncogene tyrosine-protein kinase ABL1

-
490048, 490049, 490050, 490051, 490052, 490053, 490054, 490055, 490056, 490057, 490058, 490059
proto-oncogene tyrosine-protein kinase ABL1
-
proto-oncogene tyrosine-protein kinase FES/FPS

-
proto-oncogene tyrosine-protein kinase FES/FPS
-
proto-oncogene tyrosine-protein kinase FYN

-
proto-oncogene tyrosine-protein kinase FYN
-
proto-oncogene tyrosine-protein kinase FYN
-
proto-oncogene tyrosine-protein kinase FYN
-
proto-oncogene tyrosine-protein kinase LCK

-
proto-oncogene tyrosine-protein kinase LCK
-
proto-oncogene tyrosine-protein kinase LCK
-
490114, 490115, 490116, 490117, 490118, 490119, 490120, 490121, 490122, 490123, 490124
proto-oncogene tyrosine-protein kinase SRC

-
proto-oncogene tyrosine-protein kinase SRC
-
proto-oncogene tyrosine-protein kinase SRC
-
proto-oncogene tyrosine-protein kinase YES

-
proto-oncogene tyrosine-protein kinase YES
-
proto-oncogene tyrosine-protein kinase YES
-
proto-oncogene tyrosine-protein kinase YES
-
proto-oncogene tyrosine-protein kinase YES
-
proto-oncogene tyrosine-protein kinase YES
-
PTK

-
-
-
PTK
-
-
660885, 660970, 661180, 661392, 661396, 661457, 661461, 661487, 661540, 661548, 661749, 662556, 662838, 662858, 663021, 663291, 673223, 673959, 690302, 706765, 706766
Pyk2

-
-
RAF proto-oncogene serine/threonine-protein kinase

-
RAF proto-oncogene serine/threonine-protein kinase
-
RAF proto-oncogene serine/threonine-protein kinase
-
receptor interacting protein 3

-
receptor interacting protein 3
-
receptor-interacting serine/threonine protein kinase 2

-
receptor-interacting serine/threonine protein kinase 2
-
receptor-interacting serine/threonine protein kinase 2
-
Resting lymphocyte kinase

-
-
-
Resting lymphocyte kinase
-
serine/threonine-protein kinase receptor R2

-
serine/threonine-protein kinase receptor R2
-
serine/threonine-protein kinase receptor R3

-
serine/threonine-protein kinase receptor R3
-
serine/threonine-protein kinase receptor R3
-
serine/threonine-protein kinase transforming protein mos

-
serine/threonine-protein kinase transforming protein mos
-
serine/threonine-protein kinase transforming protein mos
-
serine/threonine-protein kinase transforming protein mos
-
serine/threonine-protein kinase transforming protein mos
-
serine/threonine-protein kinase transforming protein mos
-
SFK

-
-
Spleen tyrosine kinase

-
-
-
Spleen tyrosine kinase
-
-
Spleen tyrosine kinase
-
-
Src

-
-
Src
-
-
660885, 660970, 661540, 662556, 663021, 663291, 671253, 672104, 676266, 703579, 737321, 738408, 738876
Src family kinase

-
-
Src kinase

-
-
Src protein-tyrosine kinase

-
-
Src protein-tyrosine kinase
-
-
Src protein-tyrosine kinase
-
-
Src tyrosine kinase

-
-
SRC-related intestinal kinase

-
-
-
SRC-related intestinal kinase
-
Syk

-
-
661457, 661749, 662174, 662858, 663021, 672781, 675097, 675205, 690415, 691312, 693315
Tec

-
-
Tec kinase

-
-
TESK2

-
testis-specific protein kinase 1

-
testis-specific protein kinase 1
-
testis-specific protein kinase 2

-
testis-specific protein kinase 2
-
TGF-beta receptor type I

-
TGF-beta receptor type I
-
TGF-beta receptor type I
-
TGF-beta receptor type II

-
TGF-beta receptor type II
-
TGF-beta receptor type II
-
Tyk2

-
-
tyrosine kinase Abl

-
-
tyrosine kinase Fyn

-
-
tyrosine kinase Src

-
-
tyrosine-protein kinase 6

-
tyrosine-protein kinase 6
-
tyrosine-protein kinase BLK

-
tyrosine-protein kinase BLK
-
tyrosine-protein kinase BTK

-
tyrosine-protein kinase BTK
-
tyrosine-protein kinase CSK

-
tyrosine-protein kinase CSK
-
tyrosine-protein kinase CSK
-
tyrosine-protein kinase CSK
-
tyrosine-protein kinase HCK

-
tyrosine-protein kinase HCK
-
tyrosine-protein kinase HCK
-
tyrosine-protein kinase HCK
-
tyrosine-protein kinase ITK/TSK

-
tyrosine-protein kinase ITK/TSK
-
tyrosine-protein kinase JAK1

-
tyrosine-protein kinase JAK1
-
tyrosine-protein kinase JAK1
-
tyrosine-protein kinase JAK1
-
tyrosine-protein kinase JAK2

-
tyrosine-protein kinase JAK2
-
tyrosine-protein kinase JAK2
-
tyrosine-protein kinase JAK3

-
tyrosine-protein kinase JAK3
-
tyrosine-protein kinase JAK3
-
tyrosine-protein kinase LYN

-
tyrosine-protein kinase LYN
-
tyrosine-protein kinase LYN
-
tyrosine-protein kinase SYK

-
tyrosine-protein kinase SYK
-
tyrosine-protein kinase SYK
-
tyrosine-protein kinase SYK
-
tyrosine-protein kinase Tec

-
tyrosine-protein kinase Tec
-
tyrosine-protein kinase transforming protein ABL

-
tyrosine-protein kinase transforming protein ABL
-
tyrosine-protein kinase transforming protein ABL
-
tyrosine-protein kinase transforming protein FES

-
tyrosine-protein kinase transforming protein FES
-
tyrosine-protein kinase transforming protein FES
-
tyrosine-protein kinase transforming protein FGR

-
tyrosine-protein kinase transforming protein FGR
-
tyrosine-protein kinase transforming protein fms

-
tyrosine-protein kinase transforming protein fms
-
tyrosine-protein kinase transforming protein FPS

-
tyrosine-protein kinase transforming protein FPS
-
tyrosine-protein kinase transforming protein FPS
-
tyrosine-protein kinase transforming protein ros

-
tyrosine-protein kinase transforming protein ros
-
tyrosine-protein kinase transforming protein SEA

-
tyrosine-protein kinase transforming protein SEA
-
tyrosine-protein kinase transforming protein SRC

-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein SRC
-
tyrosine-protein kinase transforming protein YES

-
tyrosine-protein kinase transforming protein YES
-
tyrosine-protein kinase TXK

-
tyrosine-protein kinase TXK
-
tyrosine-protein kinase ZAP-70

-
tyrosine-protein kinase ZAP-70
-
v-Src

-
-
WEE1hu

-
-
-
Yes

-
-
yrk

-
additional information

-
the enzymes belong to the Src family of kinases
additional information
Yes kinase is a Src-family tyrosine kinase
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
Btk is a member of the Tec family of protein kinases
additional information
-
Chk belongs to the Src family of PTKs
additional information
-
Csk belongs to the Src kinase family
additional information
-
Fyn is a tyrosine protein kinase of the Src family
additional information
-
JAK2 is a member of the Janus kinase family of PTKs
additional information
-
Lck is a member of the Src non-receptor tyrosine kinase family
additional information
-
Lyn, Hck, and Pyk-2 belong to the Src family of PTKs
additional information
-
member of the Src kinase family
additional information
-
non-receptor PTKs are grouped into several families and subfamilies
additional information
-
Syk belongs to the Syk family of protein tyrosine kinases, Src and Lyn belong to the Src family of protein tyrosine kinases
additional information
-
Syk is a member of the tyrosine kinase family
additional information
-
Syk, Fyn, and Abl belong to the Src family of PTKs
additional information
-
Tec, Btk, Itk, and Bmx are members of the Tec tyrosine kinase family
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
the enzyme belongs to the protein tyrosine kinase family
additional information
-
the enzyme belongs to the Src subfamily of the protein tyrosine kinase family
additional information
-
the enzyme belongs to the Src tyrosine kinase family
additional information
-
the enzyme belongs to the Tec nonreceptor tyrosine kinase family
additional information
-
the enzyme is a member of the Src family of tyrosine kinases
additional information
-
the Src kinase family consists of protein kinases c-Src, Fyn, Lck, Yes, Lyn, Hck, Fgr, Blk, and Yrk
additional information
-
the Src kinase family contains 11 members, i.e. protein tyrosine kinases Blk, Brk, Fgr, Frk, Fyn, Hck, Lck, Lyn, Src, Srm, and Yes
additional information
-
ZAP-70 belongs to the Syk protein tyrosine kinase family
additional information
the enzyme belongs to the nonreceptor protein-tyrosine kinase, PTK, family
additional information
-
enzymes belonging to the Src kinase family
additional information
-
PTKs of the Src kinase family
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
the enzyme belongs to the Src subfamily of the protein tyrosine kinase family
additional information
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
PTKs of the Src kinase family
additional information
-
the enzyme belongs to the Src tyrosine kinase family
additional information
-
member of the Src kinase family
additional information
-
the enzyme belongs to the Src subfamily of the protein tyrosine kinase family
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AEEEIYGEFEAKKKK + ATP
? + ADP
-
-
?
ATP + a protein
ADP + a phosphoprotein
ATP + a [homeodomain-interacting protein kinase 2]-L-tyrosine
ADP + a [homeodomain-interacting protein kinase 2]-L-tyrosine phosphate
-
-
-
?
ATP + a [peptide]-L-tyrosine
ADP + a [peptide]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
ATP + a [Tyr-2 peptide]-L-tyrosine
ADP + a [Tyr-2 peptide]-L-tyrosine phosphate
-
-
?
ATP + A-kinase anchor protein 8
?
-
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
ATP + arsenate resistance protein ARS2
?
-
-
-
?
ATP + ataxin 2 related protein
?
-
-
-
?
ATP + Bad protein
ADP + phosphotyrosinyl Bad protein
ATP + Bcl-2-associated transcription factor 1
?
-
-
-
?
ATP + beta 1-integrin cytoplasmic domain peptide
ADP + ?
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
ATP + biotin-GGEAIYAAPFKK-amide
ADP + phosphorylated biotin-GGEAIYAAPFKK-amide
-
a peptide with the preferred c-Abl substrate sequence carrying an Nterminal biotin
-
?
ATP + calponin 3
?
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
ATP + casein
ADP + phosphocasein
serine/threonine kinase activity, and no tyrosine kinase activity
-
?
ATP + Cbp
? + ADP
-
murine Csk binding protein, Cbp, amino acids 74-474, substrate used in kinase activity assay
-
?
ATP + cdc2
ADP + phosphorylated cdc2
ATP + cdc2(6-20) peptide
?
-
i.e. KVEKIGEGTYGVVYK, substrate of Src family kinases
-
?
ATP + chromosome 20 open reading frame 77
?
-
-
-
?
ATP + cleavage and polyadenylation specific factor 5
?
-
-
-
?
ATP + cofilin
ADP + phosphorylated cofilin
ATP + cortactin
?
-
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
ATP + cyclin-associated cyclin-dependent kinase
ADP + phosphorylated cyclin-associated cyclin-dependent kinase
ATP + EAIYAAPFAKKKG
ADP + EAI-pY-AAPFAKKKG
-
-
-
?
ATP + EEEEY
ADP + EEEE(phospho)Y
-
-
-
?
ATP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G
ADP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G phosphate
-
Y7 Sox-based substrate, kinetic assay
-
?
ATP + EEEPQYEEIPI +
ADP + EEEPQpYEEIPI
-
-
-
?
ATP + enolase
ADP + ?
serine/threonine kinase activity, and no tyrosine kinase activity
-
?
ATP + epidermal growth factor receptor
ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
ATP + EQEDEPEGDYFEWLE
ADP + EQEDEPEGDpYFEWLE
-
-
-
?
ATP + eukaryotic translation initiation factor 3, subunit 4
?
-
-
-
?
ATP + ewing sarcoma breakpoint region 1
?
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
ATP + F peptide
ADP + phospho-L-tyrosinyl-F peptide
-
i.e. biotin-Aca-AAAEEIFGEI-NH2
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
ATP + FUS interacting protein (serine/arginine rich) 1
?
-
-
-
?
ATP + FUS/TLS oncogene
?
-
-
-
?
ATP + FUSE binding protein
?
-
-
-
?
ATP + FUSE binding protein 2
?
-
-
-
?
ATP + GAPEVIYATPGAKKK
ADP + GAPEVI-phosphotyrosinyl-ATPGAKKK
-
consensus substrate
-
?
ATP + GGEAIYAAPFKK
ADP + GGEAIYAAPFKK phosphate
-
kinase assay using biotinylated model substrate peptide
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
ATP + heterogeneous nuclear ribonucleoprotein A3
?
-
-
-
?
ATP + heterogeneous nuclear ribonucleoprotein AB
?
-
-
-
?
ATP + heterogeneous nuclear ribonucleoprotein D-like
?
-
-
-
?
ATP + heterogeneous nuclear ribonucleoprotein K
?
-
-
-
?
ATP + histone
ADP + phosphorylated histone
serine/threonine-specific kinase activity
-
?
ATP + homeobox prox 1
?
-
-
-
?
ATP + IkappaBalpha-L-tyrosine
ADP + IkappaBalpha-L-tyrosine phosphate
ATP + KVEKIGEGTYGVVYK
? + ADP
substrate peptide used in kinase activity assay, derived from p34cdc2
-
?
ATP + KVEKIGEGTYGVVYK
ADP + ?
-
synthetic peptide substrate
-
?
ATP + lysozyme-L-tyrosine
ADP + lysozyme-L-tyrosine phosphate
-
substrate of Src, low activity with Csk or Chk
-
?
ATP + myelin basic protein
ADP + ?
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
ATP + myosin light chain
ADP + ?
serine/threonine kinase activity, and no tyrosine kinase activity
-
?
ATP + NaV1.2 channel
ADP + phospho-L-tyrosinyl-NaV1.2 channel
-
Y66 and Y1893, which are in consensus sequences appropriate for binding to the Fyn SH2 domain after phosphorylation, are both required for optimal binding and regulation by Fyn. Y730, which is located near the SH3-binding motif in LI-II, and Y1497 and Y1498 in the inactivation gate in LIII-IV, are also required for optimal regulation, but phosphorylation of these sites likely promotes fast inactivation
-
?
ATP + NEFA-interacting nuclear protein
?
-
-
-
?
ATP + P1 peptide
ADP + phospho-L-tyrosinyl-P1 peptide
-
i.e. biotin-Aca-AAAEEIpYGEI-NH2
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
ATP + p34cdc2
ADP + phosphorylated p34cdc2
ATP + PAK1
ADP + phospho-L-tyrosinyl-PAK1
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
ATP + peptide
ADP + phospho-L-tyrosinyl-peptide
-
PTKs phosphorylate substrates in a sequence-specific manner, relatively short peptide sequences determine selectivity, substrate specificity analysis using 144 different peptides, overview
-
?
ATP + PIKE-A
ADP + phosphotyrosinyl-PIKE-A
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
ATP + poly(Glu,Tyr)
? + ADP
substrate used in the tyrosine kinase asssay
-
?
ATP + poly(Glu-Tyr)
? + ADP
-
substrate used in the activity assay
-
?
ATP + poly(Glu4-Tyr)
ADP + poly(Glu-Tyr)-L-tyrosine phosphate
-
-
-
?
ATP + poly(Glu4-Tyr)
ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
ATP + poly-(Tyr-Glu)
ADP + phospho-poly-(Tyr-Glu)
-
tyrosine kinase substrate, phosphoryated by Swe1p, Mps1p, Ime2p, and Hrr25p, but not by Ste7p, Rad53p, or Mck1p
-
?
ATP + proteasome activator subunit 3
?
-
-
-
?
ATP + protein
?
CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus. By regulating the activity of these kinases, CSK may play an important role in cell growth and development
-
?
ATP + protein
ADP + protein tyrosine phosphate
ATP + protein tyrosine
ADP + protein tyrosine phosphate
ATP + protein tyrosine kinase Yes
ADP + phospho-L-tyrosinyl Yes
-
Csk inactivates the enzyme substrate
-
?
ATP + RasGAP SH3-domain binding protein
?
-
-
-
?
ATP + recombinant GST/beta3 integrin cytoplasmic tail peptide
ADP + ?
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
ATP + RNA binding motif protein 10
?
-
-
-
?
ATP + RNA binding motif protein 4B
?
-
-
-
?
ATP + S1 peptide
ADP + phospho-L-tyrosinyl-S1 peptide
-
i.e. biotin-Aca-AAAEEIYGEI-NH2
-
?
ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
ATP + signal transducer and activator of transcription
ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
ATP + similar to zinc finger CCCH-type domain-containing protein 6
?
-
-
-
?
ATP + splicing factor proline/glutamine-rich
?
-
-
-
?
ATP + splicing factor, arginine/serine-rich9
?
-
-
-
?
ATP + Src
ADP + phospho-L-tyrosinyl Src family kinase
-
wild-type Src and catalytically inactive mutant Src K295M, terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site, Glu510 of Src interacts with Arg283 of Csk in Csk-Src recognition, activity with Src fragments, overview
-
?
ATP + Src family kinase
?
-
substrate of the protein kinases CSK and CHK, which specifically phosphorylate a tyrosine residue at the C-terminus forming intramolecular bonds to the SH2 domain and inhibiting the Src family kinase, overview
-
?
ATP + Src family kinase
ADP + phospho-L-tyrosinyl Src family kinase
-
terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site
-
?
ATP + Src protein
ADP + Src protein phosphate
MATK can phosphorylate the carboxyl-terminal conserved tyrosine of the Src protein
-
?
ATP + STAT3
ADP + phospho-L-tyrosinyl-STAT3
-
-
-
?
ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
ATP + Tc10/Cdc42 GTPase-activating protein
ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
ATP + thyroid hormone receptor associated protein 3
?
-
-
-
?
ATP + TRK-fused gene
?
-
-
-
?
ATP + Tyr267 of Vav1
ADP + phosphorylated Tyr267 of Vav1
-
-
isoform c-Abl kinase probably regulates the activity of Rho guanine exchange factor Vav1 by direct phosphorylation at Tyr267 in the Dbl homology domain. The C-terminal SH3-SH2-SH3 domain and proline-rich region of Vav1 are required for its interaction with c-Abl kinase
?
ATP + zinc finger, CCHC domain containing protein 8
?
-
-
-
?
ATP + [Abi1]-L-tyrosine
ADP + [Abi1]-L-tyrosine phosphate
-
c-Abl phosphorylates Y213 of Abi1
-
?
ATP + [actin-stabilizing adapter protein HS1]-L-tyrosine
ADP + [actin-stabilizing adapter protein HS1]-L-tyrosine phosphate
-
c-Abl binds to phospho-HS1 via its SH2 domains and is required for full tyrosine phosphorylation of HS1 during T-cell activation
-
?
ATP + [androgen receptor]-L-tyrosine
ADP + [androgen receptor]-L-tyrosine phosphate
-
-
-
?
ATP + [aryl hydrocarbon receptor]-L-tyrosine
ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
ATP + [c-Cbl]-L-tyrosine
ADP + [c-Cbl]-L-tyrosine phosphate
ATP + [carrier protein-intein-CAEEEIYGEFEA]-L-tyrosine
ADP + [carrier protein-intein-CAEEEIYGEFEA]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CAEEEIYGEFEA derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGKYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGKYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGKYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTFGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTFGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTFGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTpYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTpYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTpYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYFVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYFVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYFVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYGVEYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYGVEYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVEYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYGVVFK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYGVVFK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVVFK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGKGTYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGKGTYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGKGTYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
ATP + [estrogen receptor alpha]-L-tyrosine
ADP + [estrogen receptor alpha]-L-tyrosine phosphate
-
estrogen receptor alpha associates with c-Abl nonreceptor tyrosine kinase. The direct interaction is mediated by two PXXP motifs of estrogen receptor alpha and the c-Abl SH3 domain. Estrogen receptor alpha can be phosphorylated on residues Y52 and Y219. Phosphorylation by c-Abl stabilizes estrogen recptor alpha, resulting in enhanced estrogen receptor alpha transcriptional activity and increased expression of endogenous target genes. Phosphorylation at the Y219 site affects DNA binding and dimerization by estrogen receptor alpha. c-Abl kinase activity is required for regulation of the estrogen receptor alpha function, and a Y52F/Y219F mutant estrogen receptor leads to reduced breast cancer cell growth and invasion, estrogen receptor alpha associates with c-Abl nonreceptor tyrosine kinase. The direct interaction is mediated by two PXXP motifs of estrogen receptor alpha and the c-Abl SH3 domain. Estrogen receptor alpha can be phosphorylated on residues Y52 and Y219. Phosphorylation by c-Abl stabilizes estrogen receptor alpha, resulting in enhanced estrogen receptor alpha transcriptional activity and increased expression of endogenous target genes. Phosphorylation at the Y219 site affects DNA binding and dimerization by estrogen receptor alpha
?
ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate
ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
ATP + [kdSrc kinase]-L-tyrosine
ADP + [kdSrc kinase]-L-tyrosine phosphate
ATP + [kinase Btk29]-L-tyrosine
ADP + [kinase Btk29]-L-tyrosine phosphate
-
-
-
?
ATP + [P-110]-L-tyrosine
ADP + [P-110]-L-tyrosine phosphate
-
-
-
?
ATP + [p110 catalytic subunit of PI 3-kinase]-L-tyrosine
ADP + [p110 catalytic subunit of PI 3-kinase]-L-tyrosine phosphate
-
-
-
?
ATP + [p21Cip1]-L-tyrosine
ADP + [p21Cip1]-L-tyrosine phosphate
-
-
-
?
ATP + [p27Kip1]-L-tyrosine
ADP + [p27Kip1]-L-tyrosine phosphate
-
-
-
?
ATP + [p57Kip2]-L-tyrosine
ADP + [p57Kip2]-L-tyrosine phosphate
-
-
-
?
ATP + [parkin]-Tyr143
ADP + [parkin]-phospho-Tyr143
-
-
nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, which encodes a ubiquitin E3 ligase, related to autosomal recessive Parkinson disease. Phosphorylation inhibits parkin's ubiquitin E3 ligase activity and protective function
?
ATP + [protein kinase C zeta]-L-tyrosine
ADP + [protein kinase C zeta]-L-tyrosine phosphate
-
Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
ATP + [ring canal protein]-L-tyrosine
ADP + [ring canal protein]-L-tyrosine phosphate
-
-
-
?
ATP + [Sam68]-L-tyrosine
ADP + [Sam68]-L-tyrosine phosphate
-
-
?
ATP + [Src-family protein tyrosine kinase]-L-tyrosine
ADP + [Src-family protein tyrosine kinase]-L-tyrosine phosphate
-
i.e. SFK, substrate of protein tyrosine kinases Csk and Chk, phosphorylation at the regulatory tyrosine leading to inhibition of the SFK
-
?
ATP + [Stat5B]-L-tyrosine
ADP + [Stat5B]-L-tyrosine phosphate
-
activation by non-receptor tyrosine kinase Pyk2
-
?
ATP + [transmembrane adaptor protein LAT]-L-tyrosine
ADP + [transmembrane adaptor protein LAT]-L-tyrosine phosphate
-
substrate of ZAP-70
-
?
ATP + [tubulin]-L-tyrosine
ADP + [tubulin]-L-tyrosine phosphate
-
highly active with c-Fes, which also catalyzes tubulin polymerization in vitro
-
?
ATP + [ZAP-70]-L-tyrosine
ADP + [ZAP-70]-L-tyrosine phosphate
ATP + [[Lys19]Cdc2-(6-20) peptide]-L-tyrosine
?
-
i.e. KVEKIGEGTYGVVKK
-
?
denatured enolase + ATP
phosphorylated denatured enolase + ADP
-
-
?
gelsolin + ATP
phospho-tyrosinyl gelsolin + ADP
p130Cas + ATP
phospho-tyrosinyl p130Cas + ADP
-
phosphorylation of the Crk and Nck adaptor protein by Fak
-
?
paxillin + ATP
phospho-tyrosinyl paxillin + ADP
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
Wiskott-Aldrich syndrome protein + ATP
phospho-tyrosinyl Wiskott-Aldrich syndrome protein + ADP
-
i.e. WASP, phosphorylation by Fak
-
?
additional information
?
-
ATP + a protein

ADP + a phosphoprotein
autophosphorylation
-
?
ATP + a protein
ADP + a phosphoprotein
autophosphorylation
-
?
ATP + a protein
ADP + a phosphoprotein
phosphorylates tyrosine, serine and threonine
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme controls shoot and floral meristem size
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme contributes to signal transduction
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme is required in early larval development
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
PhK phosphorylates e.g. the protein substrate GPb, v-Fps phosphorylates e.g. the peptide substrate EAEIYEAEI, Csk phosphorylates e.g. the substrate poly-Glu4-Tyr
-
?
ATP + a protein
ADP + a phosphoprotein
it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins
-
?
ATP + a protein
ADP + a phosphoprotein
autophosphorylation
-
?
ATP + a protein
ADP + a phosphoprotein
autophosphorylation
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme plays an important role in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation
-
?
ATP + a protein
ADP + a phosphoprotein
ILK is involved in agonist stimulated, Pi(3)K-dependent, PKB/AKT activation. ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3
-
?
ATP + a protein
ADP + a phosphoprotein
TESK1 has a specific function in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme induces formation of actin stress fibers and focal adhesions
-
?
ATP + a protein
ADP + a phosphoprotein
proximal mediators of IL-1 signaling
-
?
ATP + a protein
ADP + a phosphoprotein
apoptosis-inducing kinase
-
?
ATP + a protein
ADP + a phosphoprotein
NF-kappaB-activating and cell death-inducing kinase
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme functions as an intermediary in TNFalpha-induced apoptosis
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme plays a critical role in cell growth and development
-
?
ATP + a protein
ADP + a phosphoprotein
serine-threonine kinase
-
?
ATP + a protein
ADP + a phosphoprotein
role for this kinase in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
TESK1 has a specific function in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme induces formation of actin stress fibers and focal adhesions
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a [protein]-L-tyrosine

ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
660885, 661230, 661273, 661396, 661540, 663021, 702439, 703984, 703985, 704787, 705448, 705953, 706405, 706765, 706766, 737321, 737757, 738741, 739714 -
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
enzymes of the Tec tyrosine kinase family phosphorylate themselves or other family members
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
substrate docking-site and binding structure of Src involving R279, R281, and R283
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + Abl

ADP + phospho-L-tyrosinyl-Abl
-
Abl is an important substrate for Src signalling in normal cells
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is a substrate of Src
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is a substrate of Src, phosphorylation on Tyr245 and Tyr412
-
?
ATP + Akt tyrosine kinase

ADP + phosphotyrosinyl-Akt
-
-
-
?
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
-
tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview
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ATP + Bad protein

ADP + phosphotyrosinyl Bad protein
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substrate of Akt
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ATP + Bad protein
ADP + phosphotyrosinyl Bad protein
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substrate of Akt
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ATP + beta-catenin

ADP + phospho-tyrosinyl-beta-catenin
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ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
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ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
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ATP + Cas protein

ADP + phospho-tyrosinyl-Cas protein
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ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
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ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
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ATP + cdc2

ADP + phosphorylated cdc2
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ATP + cdc2
ADP + phosphorylated cdc2
the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis
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ATP + cdc2
ADP + phosphorylated cdc2
phosphorylated exclusively on Y15
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ATP + cofilin

ADP + phosphorylated cofilin
phosphorylation specifically at Ser-3
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ATP + cofilin
ADP + phosphorylated cofilin
phosphorylation specifically at Ser-3
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ATP + cortactin

ADP + phospho-tyrosinyl-cortactin
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ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
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ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
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ATP + cyclin-associated cyclin-dependent kinase

ADP + phosphorylated cyclin-associated cyclin-dependent kinase
phosphorylated on Y15
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ATP + cyclin-associated cyclin-dependent kinase
ADP + phosphorylated cyclin-associated cyclin-dependent kinase
Wee1 negatively regulates cyclin-dependent kinases by phosphorylation on Y15
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ATP + epidermal growth factor receptor

ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
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the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability
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ATP + epidermal growth factor receptor
ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
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activated Abl phosphorylates the EGFR primarily on Tyr1173, no activity with the Tyr1173 mutant substrate
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ATP + ezrin

ADP + phospho-tyrosinyl-ezrin
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ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
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ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
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ATP + FAK

ADP + phospho-tyrosinyl-FAK
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ATP + FAK
ADP + phospho-tyrosinyl-FAK
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ATP + FAK
ADP + phospho-tyrosinyl-FAK
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ATP + glycogen synthase kinase 3beta

ADP + phosphotyrosinyl glycogen synthase kinase 3beta
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substrate of Akt
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ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
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substrate of Akt
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ATP + IkappaBalpha-L-tyrosine

ADP + IkappaBalpha-L-tyrosine phosphate
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p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation, molecular mechanism, physiological role
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ATP + IkappaBalpha-L-tyrosine
ADP + IkappaBalpha-L-tyrosine phosphate
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Lck interacts via its SH2 domain with tyrosine-phosphorylated IkappaBalpha
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ATP + myelin basic protein

ADP + phosphorylated myelin basic protein
serine/threonine kinase activity
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ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
serine/threonine-specific kinase activity
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ATP + p120 protein

ADP + phospho-tyrosinyl-p120 protein
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ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
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ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
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ATP + p190 GTPase

ADP + phospho-tyrosinyl-p190 GTPase
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ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
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ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
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ATP + p32-L-tyrosine

ADP + p32-L-tyrosine phosphate
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ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
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p32 is a sperm protein
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ATP + p34cdc2

ADP + phosphorylated p34cdc2
phosphorylated exclusively on Y15
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ATP + p34cdc2
ADP + phosphorylated p34cdc2
Wee1 kinase inhibits mitosis by directly phosphorylating p34cdc2 on Y15
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ATP + PAK1

ADP + phospho-L-tyrosinyl-PAK1
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Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1
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ATP + PAK1
ADP + phospho-L-tyrosinyl-PAK1
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a serine-threonine kinase, phosphorylation at Y153, Y201, and Y285 activates PAK1, no activation of PAK1 mutants Y153F,Y201F,Y285F, mutational analysis of phosphorylation sites,overview
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ATP + paxillin

ADP + phospho-tyrosinyl-Shc paxillin
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ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
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ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
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ATP + PIKE-A

ADP + phosphotyrosinyl-PIKE-A
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i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview
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ATP + PIKE-A
ADP + phosphotyrosinyl-PIKE-A
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i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation at Y682 and Y774 by fyn, the kinase domain of activated fyn binds to the ArfGAP domain of PIKE-A, reduced activity with Y682F and with Y774F mutant PIKE-A, no activity with Y682F/Y774F mutant PIKE-A
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ATP + plakoglobin

ADP + phospho-tyrosinyl-plakoglobin
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ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
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ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
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ATP + poly(Glu4-Tyr)

ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
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ATP + poly(Glu4-Tyr)
ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
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ATP + poly(Glu4-Tyr)
ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
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artificial substrate
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ATP + protein

ADP + protein tyrosine phosphate
phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family
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ATP + protein
ADP + protein tyrosine phosphate
CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus
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ATP + protein tyrosine

ADP + protein tyrosine phosphate
protein kinase activity with specificity for tyrosine residues
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ATP + protein tyrosine
ADP + protein tyrosine phosphate
p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R
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ATP + protein tyrosine
ADP + protein tyrosine phosphate
specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain, specifically phosphorylates a negative regulatory site of p60c-src
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ATP + Rho protein

ADP + phospho-tyrosinyl-Rho protein
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ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
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ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
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ATP + Shc protein

ADP + phospho-tyrosinyl-Shc protein
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ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
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ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
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ATP + signal transducer and activator of transcription

ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
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ATP + signal transducer and activator of transcription
ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
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ATP + STAT3

ADP + phospho-tyrosinyl-STAT3
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ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
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ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
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ATP + Tc10/Cdc42 GTPase-activating protein

ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
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physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth
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ATP + Tc10/Cdc42 GTPase-activating protein
ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
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physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, phosphorylation mainly at Tyr406, no activity with TCGAP Y406F mutant, recombinant substrate from mouse and human, overview
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ATP + [aryl hydrocarbon receptor]-L-tyrosine

ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
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Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316
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ATP + [aryl hydrocarbon receptor]-L-tyrosine
ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
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in vivo assay utilizing Hep-G2 cells or H4IIE cells expressing AhR and Src kinase
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ATP + [c-Cbl]-L-tyrosine

ADP + [c-Cbl]-L-tyrosine phosphate
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proto-oncogenic PTK protein substrate
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ATP + [c-Cbl]-L-tyrosine
ADP + [c-Cbl]-L-tyrosine phosphate
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activity and phosphorylation patterns of Syk, Fyn, and Abl with recombinant wild-type and mutant Y700F, Y731F, and Y774F c-Cbl proteins, phosphorylation site preferences are determined by interaction of the enzymes' SH2 domain with the substrate via p85, a phosphatidylinositol 3-kinase, overview
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ATP + [disabled-1 adaptor protein]-L-tyrosine

ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
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ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
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activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
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ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
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ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
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activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
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ATP + [FAK]-L-tyrosine

ADP + [FAK]-L-tyrosine phosphate
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ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
activation of FAK during epiboly and gastrulation by dynamic phosphorylation at Tyr861
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ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine

ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2
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ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain
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ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine

ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2
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ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain
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ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine

ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
substrate HCN4, tyrosine 531 is phosphorylated
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ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
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substrate HCN4, tyrosine 531 is phosphorylated
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ATP + [kdSrc kinase]-L-tyrosine

ADP + [kdSrc kinase]-L-tyrosine phosphate
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i.e. kinase-defective chicken Src mutant K295M
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ATP + [kdSrc kinase]-L-tyrosine
ADP + [kdSrc kinase]-L-tyrosine phosphate