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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase
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2.7.10.2 non-specific protein-tyrosine kinaseIUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Word Map
- 2.7.10.2
- leukemia
- cytokine
- imatinib
- integrins
-
myelogenous
-
philadelphia
- metastasis
- cytoskeleton
- erk
- mapks
- t-cells
-
cytogenetic
- sh2
-
remiss
-
stats
- autophosphorylation
- hematologic
-
myeloproliferative
- fibronectin
- lymphoblastic
- lymphoma
- paxillin
- phosphatidylinositol
- adhesions
-
signal-regulated
- dasatinib
- 3-kinase
-
angiogenesis
- collagen
-
allogeneic
-
rheumatoid
- mesylate
-
dominant-negative
- phosphotyrosine
-
platelet-derived
- neoplasm
-
relapse
-
tyrosine-phosphorylated
- arthritis
- pkc
- adaptor
- oncoproteins
-
activins
-
integrin-mediated
- cd4
- crisis
-
breakpoints
- factor-beta
- c-kit
- pdgfr
- medicine
- analysis
- synthesis
- pharmacology
- drug development
The enzyme appears in viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, janus kinase 2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A-Raf proto-oncogene serine/threonine-protein kinase
Abelson murine leukemia viral homolog (1) protein
Abl
Abl kinase
Abl protein tyrosine kinase
Abl tyrosine kinase
ABL1
ABL2
ACK1
activin receptor type I
activin receptor type II
activin receptor type IIB
ACTR-IIB
AKT
anti-mullerian hormone type II receptor
B cell progenitor kinase
BCR-ABL tyrosine kinase
BCR/ABL kinase
Blk
BMP type II receptor
Bmx
bone morphogenetic protein receptor type IA
bone morphogenetic protein receptor type IB
Breast tumor kinase
Brk
Bruton tyrosine kinase
Bruton's tyrosine kinase
Brutons tyrosine kinase
Btk
c-ABL
c-Abl tyrosine kinase
C-SRC
C-SRC kinase
c-Src tyrosine kinase
C-terminal Src kinase
C-YES
Csk
ETK
FAK
Fgr
focal adhesion kinase
focal adhesion protein tyrosine
FRK
Fyn
HCK
Hematopoietic consensus tyrosine-lacking kinase
interleukin-1 receptor-associated kinase 1
Itk
JAK
Jak1
JAK2
Jak3
Janus kinase
Janus kinase 1
Janus kinase 2
Lck
Leukocyte janus kinase
LIM domain kinase 2
lymphocyte-specific protein tyrosine kinase
Lyn
Lyn tyrosine kinase
megakaryocyte-associated tyrosine-protein kinase
non-receptor protein tyrosine kinase
non-receptor PTK
non-receptor tyrosine kinase
non-receptor tyrosine-protein kinase TYK2
nonreceptor tyrosine kinase
p40mos
p56lck
PP125FAK
proline-rich tyrosine kinase 2
Protein tyrosine kinase
protein-tyrosine kinase
proto-oncogene serine/threonine-protein kinase mos
proto-oncogene tyrosine-protein kinase ABL1
proto-oncogene tyrosine-protein kinase FES/FPS
proto-oncogene tyrosine-protein kinase FYN
proto-oncogene tyrosine-protein kinase LCK
proto-oncogene tyrosine-protein kinase SRC
proto-oncogene tyrosine-protein kinase YES
PTK
Pyk2
RAF homolog serine/threonine-protein kinase dRAF-1
-
RAF proto-oncogene serine/threonine-protein kinase
receptor interacting protein 3
receptor-interacting serine/threonine protein kinase 2
Resting lymphocyte kinase
serine/threonine-protein kinase receptor R2
serine/threonine-protein kinase receptor R3
serine/threonine-protein kinase transforming protein mos
serine/threonine-protein kinase transforming protein raf
-
SFK
Spleen tyrosine kinase
Src
Src family kinase
Src kinase
Src protein-tyrosine kinase
Src tyrosine kinase
SRC-related intestinal kinase
Syk
Tec
Tec kinase
TESK2
testis-specific protein kinase 1
testis-specific protein kinase 2
TGF-beta receptor type I
TGF-beta receptor type II
Tyk2
tyrosine kinase Abl
tyrosine kinase Fyn
tyrosine kinase Src
tyrosine-protein kinase 6
tyrosine-protein kinase BLK
tyrosine-protein kinase BTK
tyrosine-protein kinase CSK
tyrosine-protein kinase HCK
tyrosine-protein kinase ITK/TSK
tyrosine-protein kinase JAK1
tyrosine-protein kinase JAK2
tyrosine-protein kinase JAK3
tyrosine-protein kinase LYN
tyrosine-protein kinase SYK
tyrosine-protein kinase Tec
tyrosine-protein kinase transforming protein ABL
tyrosine-protein kinase transforming protein FES
tyrosine-protein kinase transforming protein FGR
tyrosine-protein kinase transforming protein fms
tyrosine-protein kinase transforming protein FPS
tyrosine-protein kinase transforming protein ros
tyrosine-protein kinase transforming protein SEA
tyrosine-protein kinase transforming protein SRC
tyrosine-protein kinase transforming protein YES
tyrosine-protein kinase TXK
tyrosine-protein kinase ZAP-70
v-Src
WEE1hu
Yes
yrk
additional information
Abl tyrosine kinase
-
present in 95% of patients with chronic myelogenous leukemia, CML
JAK2
-
-
Janus kinase
-
-
Protein tyrosine kinase
-
-
proto-oncogene tyrosine-protein kinase ABL1
-
proto-oncogene tyrosine-protein kinase FYN
-
proto-oncogene tyrosine-protein kinase LCK
-
proto-oncogene tyrosine-protein kinase SRC
-
proto-oncogene tyrosine-protein kinase SRC
-
PTK
-
-
serine/threonine-protein kinase transforming protein mos
-
serine/threonine-protein kinase transforming protein mos
-
serine/threonine-protein kinase transforming protein mos
-
serine/threonine-protein kinase transforming protein mos
-
Src
-
-
Syk
-
-
tyrosine-protein kinase HCK
-
tyrosine-protein kinase transforming protein ABL
-
tyrosine-protein kinase transforming protein SRC
-
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
Lck is a member of the Src non-receptor tyrosine kinase family
additional information
-
non-receptor PTKs are grouped into several families and subfamilies
additional information
-
Syk belongs to the Syk family of protein tyrosine kinases, Src and Lyn belong to the Src family of protein tyrosine kinases
additional information
-
Tec, Btk, Itk, and Bmx are members of the Tec tyrosine kinase family
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
the enzyme belongs to the protein tyrosine kinase family
additional information
-
the enzyme belongs to the Src subfamily of the protein tyrosine kinase family
additional information
-
the enzyme belongs to the Tec nonreceptor tyrosine kinase family
additional information
-
the enzyme is a member of the Src family of tyrosine kinases
additional information
-
the Src kinase family consists of protein kinases c-Src, Fyn, Lck, Yes, Lyn, Hck, Fgr, Blk, and Yrk
additional information
-
the Src kinase family contains 11 members, i.e. protein tyrosine kinases Blk, Brk, Fgr, Frk, Fyn, Hck, Lck, Lyn, Src, Srm, and Yes
additional information
-
ZAP-70 belongs to the Syk protein tyrosine kinase family
additional information
the enzyme belongs to the nonreceptor protein-tyrosine kinase, PTK, family
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
the enzyme belongs to the Src subfamily of the protein tyrosine kinase family
additional information
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
the enzyme belongs to the Src tyrosine kinase family
additional information
-
the enzyme belongs to the Src subfamily of the protein tyrosine kinase family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
reaction mechanism
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
catalytic mechanism
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
regulation of enzyme activity involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
structure-function relation ship, active site structure, catalytic mechanism involving the catalytic base Asp386 and enzyme regulation, overview
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
substrate binding site involving residues R279, R281, and R283, more distant residues S280, F382, S273, and D276 are also important for activity
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
residue W1038 is essential for catalytic activity
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
phospho group transfer
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
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CAS REGISTRY NUMBER
COMMENTARY
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + a [homeodomain-interacting protein kinase 2]-L-tyrosine
ADP + a [homeodomain-interacting protein kinase 2]-L-tyrosine phosphate
-
-
-
?
ATP + a [Tyr-2 peptide]-L-tyrosine
ADP + a [Tyr-2 peptide]-L-tyrosine phosphate
-
-
?
ATP + biotin-GGEAIYAAPFKK-amide
ADP + phosphorylated biotin-GGEAIYAAPFKK-amide
-
a peptide with the preferred c-Abl substrate sequence carrying an Nterminal biotin
-
?
ATP + casein
ADP + phosphocasein
serine/threonine kinase activity, and no tyrosine kinase activity
-
?
ATP + Cbp
? + ADP
-
murine Csk binding protein, Cbp, amino acids 74-474, substrate used in kinase activity assay
-
?
ATP + cdc2(6-20) peptide
?
-
i.e. KVEKIGEGTYGVVYK, substrate of Src family kinases
-
?
ATP + cyclin-associated cyclin-dependent kinase
ADP + phosphorylated cyclin-associated cyclin-dependent kinase
ATP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G
ADP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G phosphate
-
Y7 Sox-based substrate, kinetic assay
-
?
ATP + enolase
ADP + ?
serine/threonine kinase activity, and no tyrosine kinase activity
-
?
ATP + epidermal growth factor receptor
ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
ATP + F peptide
ADP + phospho-L-tyrosinyl-F peptide
-
i.e. biotin-Aca-AAAEEIFGEI-NH2
-
?
ATP + GAPEVIYATPGAKKK
ADP + GAPEVI-phosphotyrosinyl-ATPGAKKK
-
consensus substrate
-
?
ATP + GGEAIYAAPFKK
ADP + GGEAIYAAPFKK phosphate
-
kinase assay using biotinylated model substrate peptide
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
ATP + histone
ADP + phosphorylated histone
serine/threonine-specific kinase activity
-
?
ATP + KVEKIGEGTYGVVYK
? + ADP
substrate peptide used in kinase activity assay, derived from p34cdc2
-
?
ATP + lysozyme-L-tyrosine
ADP + lysozyme-L-tyrosine phosphate
-
substrate of Src, low activity with Csk or Chk
-
?
ATP + myosin light chain
ADP + ?
serine/threonine kinase activity, and no tyrosine kinase activity
-
?
ATP + NaV1.2 channel
ADP + phospho-L-tyrosinyl-NaV1.2 channel
-
Y66 and Y1893, which are in consensus sequences appropriate for binding to the Fyn SH2 domain after phosphorylation, are both required for optimal binding and regulation by Fyn. Y730, which is located near the SH3-binding motif in LI-II, and Y1497 and Y1498 in the inactivation gate in LIII-IV, are also required for optimal regulation, but phosphorylation of these sites likely promotes fast inactivation
-
?
ATP + P1 peptide
ADP + phospho-L-tyrosinyl-P1 peptide
-
i.e. biotin-Aca-AAAEEIpYGEI-NH2
-
?
ATP + peptide
ADP + phospho-L-tyrosinyl-peptide
-
PTKs phosphorylate substrates in a sequence-specific manner, relatively short peptide sequences determine selectivity, substrate specificity analysis using 144 different peptides, overview
-
?
ATP + poly(Glu,Tyr)
? + ADP
substrate used in the tyrosine kinase asssay
-
?
ATP + poly-(Tyr-Glu)
ADP + phospho-poly-(Tyr-Glu)
-
tyrosine kinase substrate, phosphoryated by Swe1p, Mps1p, Ime2p, and Hrr25p, but not by Ste7p, Rad53p, or Mck1p
-
?
ATP + protein
?
CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus. By regulating the activity of these kinases, CSK may play an important role in cell growth and development
-
?
ATP + protein tyrosine kinase Yes
ADP + phospho-L-tyrosinyl Yes
-
Csk inactivates the enzyme substrate
-
?
ATP + recombinant GST/beta3 integrin cytoplasmic tail peptide
ADP + ?
-
-
?
ATP + S1 peptide
ADP + phospho-L-tyrosinyl-S1 peptide
-
i.e. biotin-Aca-AAAEEIYGEI-NH2
-
?
ATP + signal transducer and activator of transcription
ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
ATP + Src
ADP + phospho-L-tyrosinyl Src family kinase
-
wild-type Src and catalytically inactive mutant Src K295M, terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site, Glu510 of Src interacts with Arg283 of Csk in Csk-Src recognition, activity with Src fragments, overview
-
?
ATP + Src family kinase
?
-
substrate of the protein kinases CSK and CHK, which specifically phosphorylate a tyrosine residue at the C-terminus forming intramolecular bonds to the SH2 domain and inhibiting the Src family kinase, overview
-
?
ATP + Src family kinase
ADP + phospho-L-tyrosinyl Src family kinase
-
terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site
-
?
ATP + Src protein
ADP + Src protein phosphate
MATK can phosphorylate the carboxyl-terminal conserved tyrosine of the Src protein
-
?
ATP + Tc10/Cdc42 GTPase-activating protein
ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
ATP + Tyr267 of Vav1
ADP + phosphorylated Tyr267 of Vav1
-
-
isoform c-Abl kinase probably regulates the activity of Rho guanine exchange factor Vav1 by direct phosphorylation at Tyr267 in the Dbl homology domain. The C-terminal SH3-SH2-SH3 domain and proline-rich region of Vav1 are required for its interaction with c-Abl kinase
?
ATP + [Abi1]-L-tyrosine
ADP + [Abi1]-L-tyrosine phosphate
-
c-Abl phosphorylates Y213 of Abi1
-
?
ATP + [actin-stabilizing adapter protein HS1]-L-tyrosine
ADP + [actin-stabilizing adapter protein HS1]-L-tyrosine phosphate
-
c-Abl binds to phospho-HS1 via its SH2 domains and is required for full tyrosine phosphorylation of HS1 during T-cell activation
-
?
ATP + [androgen receptor]-L-tyrosine
ADP + [androgen receptor]-L-tyrosine phosphate
-
-
-
?
ATP + [aryl hydrocarbon receptor]-L-tyrosine
ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
ATP + [carrier protein-intein-CAEEEIYGEFEA]-L-tyrosine
ADP + [carrier protein-intein-CAEEEIYGEFEA]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CAEEEIYGEFEA derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGKYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGKYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGKYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTFGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTFGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTFGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTpYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTpYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTpYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYFVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYFVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYFVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYGVEYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYGVEYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVEYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYGVVFK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYGVVFK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVVFK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGEGTYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGEGTYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [carrier protein-intein-CIGKGTYGVVYK]-L-tyrosine
ADP + [carrier protein-intein-CIGKGTYGVVYK]-L-tyrosine phosphate
-
substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGKGTYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
ATP + [estrogen receptor alpha]-L-tyrosine
ADP + [estrogen receptor alpha]-L-tyrosine phosphate
-
estrogen receptor alpha associates with c-Abl nonreceptor tyrosine kinase. The direct interaction is mediated by two PXXP motifs of estrogen receptor alpha and the c-Abl SH3 domain. Estrogen receptor alpha can be phosphorylated on residues Y52 and Y219. Phosphorylation by c-Abl stabilizes estrogen recptor alpha, resulting in enhanced estrogen receptor alpha transcriptional activity and increased expression of endogenous target genes. Phosphorylation at the Y219 site affects DNA binding and dimerization by estrogen receptor alpha. c-Abl kinase activity is required for regulation of the estrogen receptor alpha function, and a Y52F/Y219F mutant estrogen receptor leads to reduced breast cancer cell growth and invasion, estrogen receptor alpha associates with c-Abl nonreceptor tyrosine kinase. The direct interaction is mediated by two PXXP motifs of estrogen receptor alpha and the c-Abl SH3 domain. Estrogen receptor alpha can be phosphorylated on residues Y52 and Y219. Phosphorylation by c-Abl stabilizes estrogen receptor alpha, resulting in enhanced estrogen receptor alpha transcriptional activity and increased expression of endogenous target genes. Phosphorylation at the Y219 site affects DNA binding and dimerization by estrogen receptor alpha
?
ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate
ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
ATP + [kinase Btk29]-L-tyrosine
ADP + [kinase Btk29]-L-tyrosine phosphate
-
-
-
?
ATP + [p110 catalytic subunit of PI 3-kinase]-L-tyrosine
ADP + [p110 catalytic subunit of PI 3-kinase]-L-tyrosine phosphate
-
-
-
?
ATP + [parkin]-Tyr143
ADP + [parkin]-phospho-Tyr143
-
-
nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, which encodes a ubiquitin E3 ligase, related to autosomal recessive Parkinson disease. Phosphorylation inhibits parkin's ubiquitin E3 ligase activity and protective function
?
ATP + [protein kinase C zeta]-L-tyrosine
ADP + [protein kinase C zeta]-L-tyrosine phosphate
-
Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation
?
ATP + [ring canal protein]-L-tyrosine
ADP + [ring canal protein]-L-tyrosine phosphate
-
-
-
?
ATP + [Src-family protein tyrosine kinase]-L-tyrosine
ADP + [Src-family protein tyrosine kinase]-L-tyrosine phosphate
-
i.e. SFK, substrate of protein tyrosine kinases Csk and Chk, phosphorylation at the regulatory tyrosine leading to inhibition of the SFK
-
?
ATP + [Stat5B]-L-tyrosine
ADP + [Stat5B]-L-tyrosine phosphate
-
activation by non-receptor tyrosine kinase Pyk2
-
?
ATP + [transmembrane adaptor protein LAT]-L-tyrosine
ADP + [transmembrane adaptor protein LAT]-L-tyrosine phosphate
-
substrate of ZAP-70
-
?
ATP + [tubulin]-L-tyrosine
ADP + [tubulin]-L-tyrosine phosphate
-
highly active with c-Fes, which also catalyzes tubulin polymerization in vitro
-
?
p130Cas + ATP
phospho-tyrosinyl p130Cas + ADP
-
phosphorylation of the Crk and Nck adaptor protein by Fak
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
Wiskott-Aldrich syndrome protein + ATP
phospho-tyrosinyl Wiskott-Aldrich syndrome protein + ADP
-
i.e. WASP, phosphorylation by Fak
-
?
ATP + a protein
ADP + a phosphoprotein
autophosphorylation
-
?
ATP + a protein
ADP + a phosphoprotein
phosphorylates tyrosine, serine and threonine
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme controls shoot and floral meristem size
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme contributes to signal transduction
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme is required in early larval development
-
?
ATP + a protein
ADP + a phosphoprotein
-
PhK phosphorylates e.g. the protein substrate GPb, v-Fps phosphorylates e.g. the peptide substrate EAEIYEAEI, Csk phosphorylates e.g. the substrate poly-Glu4-Tyr
-
?
ATP + a protein
ADP + a phosphoprotein
it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme plays an important role in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation
-
?
ATP + a protein
ADP + a phosphoprotein
ILK is involved in agonist stimulated, Pi(3)K-dependent, PKB/AKT activation. ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3
-
?
ATP + a protein
ADP + a phosphoprotein
TESK1 has a specific function in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme induces formation of actin stress fibers and focal adhesions
-
?
ATP + a protein
ADP + a phosphoprotein
proximal mediators of IL-1 signaling
-
?
ATP + a protein
ADP + a phosphoprotein
NF-kappaB-activating and cell death-inducing kinase
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme functions as an intermediary in TNFalpha-induced apoptosis
-
?
ATP + a protein
ADP + a phosphoprotein
enzyme plays a critical role in cell growth and development
-
?
ATP + a protein
ADP + a phosphoprotein
role for this kinase in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
TESK1 has a specific function in spermatogenesis
-
?
ATP + a protein
ADP + a phosphoprotein
the enzyme induces formation of actin stress fibers and focal adhesions
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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660885, 661230, 661273, 661396, 661540, 663021, 702439, 703984, 703985, 704787, 705448, 705953, 706405, 706765, 706766, 737321, 737757, 738741, 739714
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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enzymes of the Tec tyrosine kinase family phosphorylate themselves or other family members
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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substrate docking-site and binding structure of Src involving R279, R281, and R283
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
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ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
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Abl is an important substrate for Src signalling in normal cells
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ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
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Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview
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ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
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Abl is a substrate of Src, phosphorylation on Tyr245 and Tyr412
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ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
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tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview
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ATP + cdc2
ADP + phosphorylated cdc2
the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis
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ATP + cdc2
ADP + phosphorylated cdc2
phosphorylated exclusively on Y15
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ATP + cofilin
ADP + phosphorylated cofilin
phosphorylation specifically at Ser-3
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ATP + cofilin
ADP + phosphorylated cofilin
phosphorylation specifically at Ser-3
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ATP + cyclin-associated cyclin-dependent kinase
ADP + phosphorylated cyclin-associated cyclin-dependent kinase
phosphorylated on Y15
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ATP + cyclin-associated cyclin-dependent kinase
ADP + phosphorylated cyclin-associated cyclin-dependent kinase
Wee1 negatively regulates cyclin-dependent kinases by phosphorylation on Y15
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ATP + epidermal growth factor receptor
ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
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the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability
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ATP + epidermal growth factor receptor
ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
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activated Abl phosphorylates the EGFR primarily on Tyr1173, no activity with the Tyr1173 mutant substrate
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ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
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substrate of Akt
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ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
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substrate of Akt
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ATP + IkappaBalpha-L-tyrosine
ADP + IkappaBalpha-L-tyrosine phosphate
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p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation, molecular mechanism, physiological role
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ATP + IkappaBalpha-L-tyrosine
ADP + IkappaBalpha-L-tyrosine phosphate
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Lck interacts via its SH2 domain with tyrosine-phosphorylated IkappaBalpha
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ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
serine/threonine kinase activity
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ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
serine/threonine-specific kinase activity
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ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
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p32 is a sperm protein
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ATP + p34cdc2
ADP + phosphorylated p34cdc2
phosphorylated exclusively on Y15
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ATP + p34cdc2
ADP + phosphorylated p34cdc2
Wee1 kinase inhibits mitosis by directly phosphorylating p34cdc2 on Y15
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ATP + PAK1
ADP + phospho-L-tyrosinyl-PAK1
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Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1
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ATP + PAK1
ADP + phospho-L-tyrosinyl-PAK1
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a serine-threonine kinase, phosphorylation at Y153, Y201, and Y285 activates PAK1, no activation of PAK1 mutants Y153F,Y201F,Y285F, mutational analysis of phosphorylation sites,overview
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ATP + PIKE-A
ADP + phosphotyrosinyl-PIKE-A
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i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview
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ATP + PIKE-A
ADP + phosphotyrosinyl-PIKE-A
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i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation at Y682 and Y774 by fyn, the kinase domain of activated fyn binds to the ArfGAP domain of PIKE-A, reduced activity with Y682F and with Y774F mutant PIKE-A, no activity with Y682F/Y774F mutant PIKE-A
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ATP + poly(Glu4-Tyr)
ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
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ATP + poly(Glu4-Tyr)
ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
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artificial substrate
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ATP + protein
ADP + protein tyrosine phosphate
phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family
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ATP + protein
ADP + protein tyrosine phosphate
CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus
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ATP + protein tyrosine
ADP + protein tyrosine phosphate
protein kinase activity with specificity for tyrosine residues
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ATP + protein tyrosine
ADP + protein tyrosine phosphate
p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R
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ATP + protein tyrosine
ADP + protein tyrosine phosphate
specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain, specifically phosphorylates a negative regulatory site of p60c-src
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ATP + signal transducer and activator of transcription
ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
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ATP + signal transducer and activator of transcription
ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
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ATP + Tc10/Cdc42 GTPase-activating protein
ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
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physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth
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ATP + Tc10/Cdc42 GTPase-activating protein
ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
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physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, phosphorylation mainly at Tyr406, no activity with TCGAP Y406F mutant, recombinant substrate from mouse and human, overview
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ATP + [aryl hydrocarbon receptor]-L-tyrosine
ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
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Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316
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ATP + [aryl hydrocarbon receptor]-L-tyrosine
ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
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in vivo assay utilizing Hep-G2 cells or H4IIE cells expressing AhR and Src kinase
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ATP + [c-Cbl]-L-tyrosine
ADP + [c-Cbl]-L-tyrosine phosphate
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proto-oncogenic PTK protein substrate
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ATP + [c-Cbl]-L-tyrosine
ADP + [c-Cbl]-L-tyrosine phosphate
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activity and phosphorylation patterns of Syk, Fyn, and Abl with recombinant wild-type and mutant Y700F, Y731F, and Y774F c-Cbl proteins, phosphorylation site preferences are determined by interaction of the enzymes' SH2 domain with the substrate via p85, a phosphatidylinositol 3-kinase, overview
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ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
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ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
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activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
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ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
Mus musculus C57BL6J/129Sv
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ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
Mus musculus C57BL6J/129Sv
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activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
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ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
activation of FAK during epiboly and gastrulation by dynamic phosphorylation at Tyr861
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ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2
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ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain
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ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2
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ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine
ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate
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activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain
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ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
substrate HCN4, tyrosine 531 is phosphorylated
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ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
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substrate HCN4, tyrosine 531 is phosphorylated
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ATP + [kdSrc kinase]-L-tyrosine
ADP + [kdSrc kinase]-L-tyrosine phosphate
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i.e. kinase-defective chicken Src mutant K295M
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ATP + [kdSrc kinase]-L-tyrosine
ADP + [kdSrc kinase]-L-tyrosine phosphate