Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PYK2 is phosphorylated for activation involving the vascular endothelial growth factor, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | PYK2-deficient phenotype with reduced vasodilatation, response to NO, and neovessel formation, detailed overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, PYK2 is involved in Ca2+ mobilization in muscle cells | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Akt tyrosine kinase | Mus musculus | tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview | ADP + phosphotyrosinyl-Akt | - |
? | |
additional information | Mus musculus | PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PYK2 is phosphorylated for activation involving the vascular endothelial growth factor, while tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway overview | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | endothelial cells, PYK2 | Mus musculus | - |
endothelial cell | aortic, PYK2, von Willebrand factor-positive cells | Mus musculus | - |
skeletal muscle | Akt | Mus musculus | - |
vascular smooth muscle cell | PYK2 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Akt tyrosine kinase | - |
Mus musculus | ADP + phosphotyrosinyl-Akt | - |
? | |
ATP + Akt tyrosine kinase | tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview | Mus musculus | ADP + phosphotyrosinyl-Akt | - |
? | |
additional information | PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium-dependent tyrosine kinase PYK2 | - |
Mus musculus |
Pyk2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |