Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
57900 | - |
calculated from amino acid sequence | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HMC-1 cell | - |
Homo sapiens | - |
mast cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | - |
Homo sapiens | ATP + pyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pyruvate kinase type M2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | calculated from amino acid sequence | - |
8 |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | pyruvate kinase activities are increased by 52.4% in nerve growth factor treatment compared to the cells cultured by horse serum media | up |
General Information | Comment | Organism |
---|---|---|
physiological function | pyruvate kinase and annexin I expressed by nerve growth factor contributes to granule formation containing TNF-alpha as well as other mediators in mast cells, which play a major role in allergic diseases via a TrkA/ERK pathway | Homo sapiens |