Application | Comment | Organism |
---|---|---|
medicine | overexpression of promyelocytic leukemia tumor suppressor protein mutant PML-2KA in the cytoplasm suppresses M2-type pyruvate kinase activity and the accumulation of lactate. PML-2KA suppresses the activity of the high-affinity terameric form of M2-type pyruvate kinase, but not of the low-affinity dimeric form | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of promyelocytic leukemia tumor suppressor protein mutant PML-2KA in the cytoplasm suppresses M2-type pyruvate kinase activity and the accumulation of lactate. PML-2KA suppresses the activity of the high-affinity terameric form of M2-type pyruvate kinase, but not of the low-affinity dimeric form | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform M2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | M2-type enzyme directly interacts with promyelocytic leukemia tumor suppressor protein | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PKM2 | - |
Homo sapiens |