hanging drop vapor diffusion method, high-resolution crystal structures are solved for two native forms and one covalently inhibited form of Salmonella typhimurium ArnB (crystal structure of ArnB aminotransferase with pyridomine 5'-phosphate, crystal structure of ArnB transferase with pyridoxal 5'-phosphate, crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5'-phosphate)

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

Salmonella enterica subsp. enterica serovar Typhimurium

lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

r

Salmonella enterica subsp. enterica serovar Typhimurium

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

701247

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

r

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway

701247

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

r

hanging drop vapor diffusion method, high-resolution crystal structures are solved for two native forms and one covalently inhibited form of Salmonella typhimurium ArnB (crystal structure of ArnB aminotransferase with pyridomine 5'-phosphate, crystal structure of ArnB transferase with pyridoxal 5'-phosphate, crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5'-phosphate)

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

Salmonella enterica subsp. enterica serovar Typhimurium

lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

r

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

701247

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

r

UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway

701247

Salmonella enterica subsp. enterica serovar Typhimurium

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate

r

698724

Breazeale

Origin of lipid A species modi ...

J. Biol. Chem.