ArnB catalyzes the reversible transfer of the amino group from glutamate to the acceptor, uridine 5'-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate), the intermediate that is synthesized by ArnA from UDP-glucuronic acid.the enzyme is highly selective for glutamate as the amine donor, but the equilibrium constant in the direction of UDP-4-amino-4-deoxy-beta-L-arabinose formation is unfavorable
the enzyme is highly selective for glutamate as the amine donor, but the equilibrium constant in the direction of UDP-4-amino-4-deoxy-beta-L-arabinose formation is unfavorable. The rate of transamination with L-methionine, L-glutamine, and L-alanine is measurable at 5%, 2%, and 1%, respectively, of the rate observed with L-glutamate
lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway
ArnB catalyzes the reversible transfer of the amino group from glutamate to the acceptor, uridine 5'-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate), the intermediate that is synthesized by ArnA from UDP-glucuronic acid.the enzyme is highly selective for glutamate as the amine donor, but the equilibrium constant in the direction of UDP-4-amino-4-deoxy-beta-L-arabinose formation is unfavorable
lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method, high-resolution crystal structures are solved for two native forms and one covalently inhibited form of Salmonella typhimurium ArnB (crystal structure of ArnB aminotransferase with pyridomine 5'-phosphate, crystal structure of ArnB transferase with pyridoxal 5'-phosphate, crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5'-phosphate)
Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose